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1998 Guidelines for Treatment of Sexually Transmitted Disease HTTP/1.1 404 Object Not Found Server: Microsoft-IIS/5.0 Date: Mon, 23 Nov 2009 20:53:00 GMT Connection: close Content-Type: text/html

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TABLE 1. Oral desensitization protocol for patients with a positive skin test *
==============================================================================================
  Penicillin V       Amount &                       Cumulative
suspension dose +   (units/mL)    mL     Units     dose (units)
---------------------------------------------------------------
        1              1,000     0.1        100            100
        2              1,000     0.2        200            300
        3              1,000     0.4        400            700
        4              1,000     0.8        800          1,500
        5              1,000     1.6      1,600          3,100
        6              1,000     3.2      3,200          6,300
        7              1,000     6.4      6,400         12,700
        8             10,000     1.2     12,000         24,700
        9             10,000     2.4     24,000         48,700
       10             10,000     4.8     48,000         96,700
       11             80,000     1.0     80,000        176,700
       12             80,000     2.0    160,000        336,700
       13             80,000     4.0    320,000        656,700
       14             80,000     8.0    640,000      1,296,700
---------------------------------------------------------------
Observation period: 30 minutes before parenteral administration of penicillin.

* Reprinted with permission from the New England Journal of Medicine (24).
+ Interval between doses, 15 minutes; elapsed time, 3 hours and 45 minutes; cumulative dose,
  1.3 million units.
& The specific amount of drug was diluted in approximately 30 mL of water and then adminis-
  tered orally.
==============================================================================================
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