Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 5. Reported cases of notifiable diseases and rates per 100,000, by sex, excluding U.S. territories - - United States, 2016
Disease Female Male Sex not stated Total
No. Rate No. Rate No. No.
Anthrax — — — — — —
Arboviral diseases
Chikungunya virus disease 134 0.08 113 0.07 — 247
Eastern equine encephalitis virus disease
Neuroinvasive 1 0.00 6 0.00 — 7
Non-neuroinvasive — — — — — —
Jamestown Canyon virus disease
Neuroinvasive 2 0.00 5 0.00 — 7
Non-neuroinvasive 1 0.00 7 0.00 — 8
La Crosse virus disease
Neuroinvasive 10 0.01 21 0.01 — 31
Non-neuroinvasive — — 4 0.00 — 4
Powassan virus disease
Neuroinvasive 7 0.00 14 0.01 — 21
Non-neuroinvasive 1 0.00 — — — 1
St. Louis encephalitis virus disease
Neuroinvasive 3 0.00 4 0.00 — 7
Non-neuroinvasive — — 1 0.00 — 1
West Nile virus disease
Neuroinvasive 463 0.28 845 0.53 — 1,308
Non-neuroinvasive 362 0.22 479 0.30 — 841
Western equine encephalitis virus disease
Neuroinvasive — — — — — —
Non-neuroinvasive — — — — — —
Babesiosis
Total 659 0.57 1,246 1.10 5 1,910
Confirmed 536 0.46 1,045 0.92 4 1,585
Probable 123 0.11 201 0.18 1 325
Botulism
Total 82 0.05 118 0.07 1 201
Foodborne 7 0.00 24 0.02 — 31
Infant * 67 3.45 76 3.74 1 144
Other (wound & unspecified) 8 0.00 18 0.01 — 26
Brucellosis 49 0.03 77 0.05 1 127
Campylobacteriosis 28,398 17.31 31,424 19.75 298 60,120
Chancroid 1 0.00 6 0.00 — 7
Chlamydia trachomatis infection 1,072,719 653.90 522,870 328.69 2,765 1,598,354
Cholera 8 0.00 7 0.00 — 15
Coccidioidomycosis † 5,106 7.70 6,701 10.33 22 11,829
Cryptosporidiosis
Total 6,904 4.21 6,454 4.06 95 13,453
Confirmed 4,346 2.65 4,254 2.67 37 8,637
Probable 2,558 1.56 2,200 1.38 58 4,816
Cyclosporiasis 325 0.22 211 0.15 1 537
Dengue virus infections §
Dengue 447 0.27 456 0.29 — 903
Dengue-like illness 16 0.01 24 0.02 — 40
Severe dengue 4 0.00 6 0.00 — 10
Diphtheria — — — — — —
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection 1,596 1.01 2,473 1.61 82 4,151
Ehrlichia chaffeensis infection 529 0.33 846 0.55 2 1,377
Ehrlichia ewingii infection 11 0.01 11 0.01 — 22
Undetermined ehrlichiosis/anaplasmosis 96 0.06 104 0.07 — 200
Giardiasis 6,490 5.04 9,770 7.82 50 16,310
Gonorrhea 197,499 120.39 270,033 169.75 982 468,514
Haemophilus influenzae, invasive disease
All ages, all serotypes 2,634 1.61 2,233 1.40 28 4,895
Age <5 years 
Serotype b 11 0.11 19 0.19 — 30
Non-b serotype 67 0.69 92 0.90 — 159
Nontypeable 89 0.91 106 1.04 1 196
Unknown serotype 83 0.85 103 1.01 1 187
Hansen's disease 17 0.01 46 0.03 15 78
Hantavirus infection, non-hantavirus pulmonary syndrome 2 0.00 4 0.00 — 6
Hantavirus pulmonary syndrome 13 0.01 18 0.01 — 31
Hemolytic uremic syndrome post-diarrheal 181 0.11 125 0.08 1 307
Hepatitis **
A, acute 897 0.55 1,107 0.70 3 2,007
B, acute 1,252 0.77 1,957 1.24 9 3,218
B, perinatal infection †† 11 0.28 21 0.52 — 32
C, acute 1,310 0.85 1,627 1.08 5 2,942
Human immunodeficiency virus diagnoses 6,631 4.04 28,144 17.69 — 34,775
Influenza-associated pediatric mortality §§ 48 0.13 34 0.09 — 82
Invasive pneumococcal disease
All ages 8,400 6.86 9,125 7.71 101 17,626
Confirmed 8,390 6.85 9,112 7.70 101 17,603
Probable 10 0.01 13 0.01 — 23
Age <5 years  484 0.37 652 0.51 6 1,142
Confirmed 481 6.17 650 7.98 6 1,137
Probable 3 0.04 2 0.02 — 5
Legionellosis 2,458 1.50 3,679 2.31 4 6,141
Leptospirosis 18 0.01 60 0.05 — 78
Listeriosis 401 0.24 383 0.24 2 786
Lyme disease
Total 15,307 9.37 20,567 12.99 555 36,429
Confirmed 10,971 6.72 14,810 9.35 422 26,203
Probable 4,336 2.65 5,757 3.64 133 10,226
Malaria 743 0.45 1,194 0.75 18 1,955
Measles
Total 24 0.01 61 0.04 — 85
Indigenous 19 0.01 49 0.03 — 68
Imported 5 0.00 12 0.01 — 17
Meningococcal disease
All serogroups 173 0.11 202 0.13 — 375
Serogroups ACWY 62 0.04 64 0.04 — 126
Serogroup B 41 0.02 45 0.03 — 86
Other serogroups 9 0.01 12 0.01 — 21
Unknown serogroup 61 0.04 81 0.05 — 142
Mumps 3,147 1.92 3,194 2.01 28 6,369
Novel Influenza A virus infections 9 0.01 14 0.01 — 23
Pertussis 9,900 6.03 8,029 5.05 43 17,972
Plague — — 4 0.00 — 4
Poliomyelitis, paralytic — — — — — —
Poliovirus infection, nonparalytic — — — — — —
Psittacosis 8 0.01 4 0.00 — 12
Q fever
Total 34 0.02 130 0.08 — 164
Acute 27 0.02 105 0.07 — 132
Chronic 7 0.00 25 0.02 — 32
Rabies
Human — — — — — —
Rubella — — 1 0.00 — 1
Rubella, congenital syndrome * 2 0.10 — — — 2
Salmonellosis 28,379 17.30 25,090 15.77 381 53,850
Severe acute respiratory syndrome-associated coronavirus disease — — — — — —
Shiga toxin-producing Escherichia coli ¶¶ 4,521 2.76 3,614 2.27 34 8,169
Shigellosis 10,579 6.45 10,359 6.51 159 21,097
Smallpox — — — — — —
Spotted fever rickettsiosis
Total 1,442 0.88 2,823 1.79 4 4,269
Confirmed 46 0.03 108 0.07 — 154
Probable 1,396 0.86 2,715 1.72 4 4,115
Streptococcal toxic shock syndrome 146 0.14 137 0.13 — 283
Syphilis
Total, all stages *** 14,848 9.05 72,433 45.53 761 88,042
Congenital * — — — — 628 628
Primary and secondary 3,049 1.86 24,724 15.54 41 27,814
Tetanus 11 0.01 22 0.01 1 34
Toxic shock syndrome (other than Streptococcal) 28 0.02 11 0.01 1 40
Trichinellosis 6 0.00 20 0.01 — 26
Tuberculosis 3,633 2.21 5,639 3.54 — 9,272
Tularemia 76 0.05 153 0.10 1 230
Typhoid fever 177 0.11 197 0.12 2 376
Vancomycin-intermediate Staphylococcus aureus 46 0.04 62 0.05 — 108
Vancomycin-resistant Staphylococcus aureus — — — — — —
Varicella morbidity 4,330 3.28 4,581 3.58 42 8,953
Varicella mortality U U U U U U
Vibriosis
Total 437 0.27 824 0.53 12 1,273
Confirmed 422 0.26 807 0.52 12 1,241
Probable 15 0.01 17 0.01 — 32
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus — — — — — —
Ebola virus — — — — — —
Guanarito virus — — — — — —
Junin virus — — — — — —
Lassa virus — — — — — —
Lujo virus — — — — — —
Machupo virus — — — — — —
Marburg virus — — — — — —
Sabia virus — — — — — —
Yellow fever — — 1 0.00 — 1
Zika virus
Zika virus disease, congenital *,††† 17 0.88 13 0.64 — 30
Zika virus disease, non-congenital 3,290 2.01 1,842 1.16 — 5,132
Zika virus infection, congenital *,††† 23 1.19 22 1.08 — 45
Zika virus infection, non-congenital 852 0.52 58 0.04 1 911
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • U: Unavailable — The data are unavailable.
  • * The rate is calculated using population less than 1 year of age.
  • † Reportable in <25 states.
  • § Total number of reported laboratory-positive dengue cases, including all confirmed cases [by anti-dengue virus (DENV) molecular diagnostic methods or seroconversion of anti-DENV IgM] and all probable cases (by a single, positive anti-DENV IgM).
  • ¶ The rate is calculated using population less than 5 years of age.
  • ** Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/2015surveillance/index.htm.
  • †† The rate is calculated using population less than 2 years of age.
  • §§ The rate is calculated using population less than 18 years of age.
  • ¶¶ Includes Escherichia coli O157:H7; shiga toxin-positive, serogroup non-O157; and shiga toxin positive, not serogrouped.
  • *** Includes syphilis of all stages, including cases where stage of syphilis is not stated.
  • ††† Data reported to ArboNET using the national surveillance case definition for congenital Zika virus disease or infection (CSTE Position Statement 16-ID-01). Additional data reported to the US Zika Pregnancy Registry for outcomes of pregnancies with laboratory evidence of possible Zika virus infection are available at https://www.cdc.gov/zika/reporting/pregnancy-outcomes.html. Cases reported to the US Zika Pregnancy Registry might not meet the national surveillance case definition for congenital Zika virus disease or infection.
Notes:
  • These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables.
  • The list of nationally notifiable infectious diseases and conditions for 2016 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2016" for the notifiable condition list year, checking "infectious" conditions, and clicking "Get Notifiable List by Year". This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved in 2015 by CSTE for national surveillance, that were implemented in January 2016, including updated surveillance case definitions for acute hepatitis C and chronic hepatitis C virus infections. 2016 data are reported through June 30, 2017. Publication criteria for the finalized 2016 data are available at /nndss/documents/2016_NNDSS_Publication_Criteria.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  • Population estimates for incidence rates are July 1st, 2016 estimates obtained from the National Center for Health Statistics (NCHS) postcensal estimates of the resident population of the United States for July 1, 2011 - July 1, 2016, by year, county, single year of age (range: 0 to 85 years), bridged-race (white, black or African American, American Indian or Alaska Native, Asian, or Pacific Islander), Hispanic ethnicity (not Hispanic or Latino, Hispanic or Latino), and sex (Vintage 2016), prepared under a collaborative arrangement with the U.S. Census Bureau. Population estimates for states as of June 26, 2017 are available at https://www.cdc.gov/nchs/nvss/bridged_race/data_documentation.htm. Population estimates for territories are the 2016 mid-year estimates from the U.S. Census Bureau International Data Base accessed on July 24, 2017 at https://www.census.gov/population/international/data/idb/informationGateway.php. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  • Annual tables for 2016 and later years are available on CDC WONDER.
  • Annual summary reports from 1993-2015 are available as published in the MMWR.
  • NNDSS annual tables since 1952 are available at CDC Stacks (once in CDC Stacks select "Annual Reports" in the "Genre" box to the left).
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