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Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 1. Annual reported cases of notifiable diseases and rates per 100,000, excluding U.S. Territories - - United States, 2018
Disease Case Count Rate
Anthrax 1 0.00
Arboviral diseases
Chikungunya virus disease 117 0.04
Eastern equine encephalitis virus disease
Neuroinvasive 6 0.00
Non-neuroinvasive
Jamestown Canyon virus disease
Neuroinvasive 25 0.01
Non-neuroinvasive 16 0.00
La Crosse virus disease
Neuroinvasive 83 0.03
Non-neuroinvasive 3 0.00
Powassan virus disease
Neuroinvasive 21 0.01
Non-neuroinvasive
St. Louis encephalitis virus disease
Neuroinvasive 5 0.00
Non-neuroinvasive 3 0.00
West Nile virus disease
Neuroinvasive 1,657 0.51
Non-neuroinvasive 989 0.30
Western equine encephalitis virus disease
Neuroinvasive
Non-neuroinvasive
Babesiosis
Total 2,160 0.79
Confirmed 1,861 0.68
Probable 299 0.11
Botulism
Total 225 0.07
Foodborne 17 0.01
Infant 157 4.08
Other (wound & unspecified) 51 0.02
Brucellosis 138 0.04
Campylobacteriosis 70,200 21.46
Chancroid 3 0.00
Chlamydia trachomatis infection 1,758,668 537.54
Cholera 14 0.00
Coccidioidomycosis * 15,611 11.58
Cryptosporidiosis
Total 12,533 3.83
Confirmed 8,980 2.74
Probable 3,553 1.09
Cyclosporiasis 3,519 1.20
Dengue virus infections 
Dengue 424 0.13
Dengue-like illness 41 0.01
Severe dengue 9 0.00
Diphtheria 1 0.00
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection 4,008 1.27
Ehrlichia chaffeensis infection 1,799 0.57
Ehrlichia ewingii infection 33 0.01
Undetermined ehrlichiosis/anaplasmosis 283 0.09
Giardiasis 15,548 6.06
Gonorrhea 583,405 178.32
Haemophilus influenzae, invasive disease
All ages, all serotypes 5,573 1.70
Age <5 years
Serotype b 38 0.19
Non-b serotype 191 0.96
Nontypeable 222 1.12
Unknown serotype 175 0.88
Hansen's disease 90 0.03
Hantavirus infection, non-hantavirus pulmonary syndrome 2 0.00
Hantavirus pulmonary syndrome 18 0.01
Hemolytic uremic syndrome post-diarrheal 376 0.12
Hepatitis §
A, acute 12,474 3.81
B, acute 3,322 1.02
B, perinatal infection 23 0.30
C, acute 4,768 1.54
Confirmed 3,621 1.17
Probable 1,147 0.37
C, perinatal infection 214 0.07
Human immunodeficiency virus diagnoses 32,999 10.09
Influenza-associated pediatric mortality 159 0.22
Invasive pneumococcal disease 
All ages 19,857 8.14
Confirmed 19,619 8.04
Probable 238 0.10
Age <5 years 1,116 0.43
Confirmed 1,078 6.80
Probable 38 0.24
Legionellosis 9,933 3.04
Leptospirosis 91 0.04
Listeriosis 864 0.26
Lyme disease
Total 33,666 10.34
Confirmed 23,558 7.23
Probable 10,108 3.10
Malaria 1,748 0.53
Measles
Total 375 0.11
Indigenous 296 0.09
Imported 79 0.02
Meningococcal disease
All serogroups 327 0.10
Serogroups ACWY 100 0.03
Serogroup B 81 0.02
Other serogroups 23 0.01
Unknown serogroup 123 0.04
Mumps 2,515 0.77
Novel Influenza A virus infections 14 0.00
Paratyphoid fever ** 133 0.04
Pertussis 15,609 4.77
Plague 1 0.00
Poliomyelitis, paralytic
Poliovirus infection, nonparalytic
Psittacosis 22 0.01
Q fever
Total 215 0.07
Acute 178 0.05
Chronic 37 0.01
Rabies
Animal 4,984 1.52
Human 3 0.00
Rubella 4 0.00
Rubella, congenital syndrome
Salmonellosis (excluding paratyphoid fever and typhoid fever) †† 60,999 18.64
Severe acute respiratory syndrome-associated coronavirus disease
Shiga toxin-producing Escherichia coli (STEC) 15,996 4.89
Shigellosis 16,333 4.99
Smallpox
Spotted fever rickettsiosis
Total 5,544 1.71
Confirmed 124 0.04
Probable 5,420 1.67
Streptococcal toxic shock syndrome 371 0.18
Syphilis
Total, all stages §§ 115,045 35.16
Congenital 1,306 34.44
Primary and secondary 35,063 10.72
Tetanus 23 0.01
Toxic shock syndrome (other than Streptococcal) 33 0.01
Trichinellosis 1 0.00
Tuberculosis 9,025 2.76
Tularemia 229 0.07
Typhoid fever 401 0.12
Vancomycin-intermediate Staphylococcus aureus 85 0.03
Vancomycin-resistant Staphylococcus aureus
Varicella morbidity 8,201 3.07
Varicella mortality 6 0.00
Vibriosis
Total 2,964 0.92
Confirmed 1,822 0.57
Probable 1,142 0.35
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus
Ebola virus
Guanarito virus
Junin virus
Lassa virus
Lujo virus
Machupo virus
Marburg virus
Sabia virus
Yellow fever
Zika virus
Zika virus disease, congenital ¶¶ 2 0.05
Zika virus disease, non-congenital 79 0.02
Zika virus infection, congenital ¶¶ 8 0.21
Zika virus infection, non-congenital 245 0.07
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • * Reportable in <25 states.
  • † Counts include confirmed and probable dengue cases.
  • § Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/SurveillanceRpts.htm.
  • ¶ Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years.
  • ** Prior to 2018, cases of paratyphoid fever were considered salmonellosis.
  • †† Prior to 2018, cases of paratyphoid fever were included as salmonellosis, but beginning in 2018 they are being published as paratyphoid fever.
  • §§ Includes the following categories: primary; secondary; early non-primary non-secondary (includes cases previously reported as early latent); and unknown duration or late (includes cases previously reported as late latent syphilis and cases previously reported as late syphilis with clinical manifestations).
  • ¶¶ Data reported to ArboNET using the national surveillance case definition for congenital Zika virus infection (CSTE Position Statement 16-ID-01).

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