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Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 4. Annual reported cases of notifiable diseases and rates per 100,000, by age, excluding U.S. Territories - - United States, 2018
Disease <1 yr 1-4 yrs 5-14 yrs 15-24 yrs 25-39 yrs 40-64 yrs ≥65 yrs Age not stated Total
No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. No.
Anthrax 1 0.00 1
Arboviral diseases
Chikungunya virus disease 1 0.03 2 0.01 8 0.02 9 0.02 41 0.06 45 0.04 11 0.02 117
Eastern equine encephalitis virus disease
Neuroinvasive 3 0.00 3 0.01 6
Non-neuroinvasive
Jamestown Canyon virus disease
Neuroinvasive 4 0.01 4 0.01 10 0.01 7 0.01 25
Non-neuroinvasive 2 0.00 10 0.01 4 0.01 16
La Crosse virus disease
Neuroinvasive 2 0.05 14 0.09 58 0.14 4 0.01 2 0.00 2 0.00 1 0.00 83
Non-neuroinvasive 3 0.01 3
Powassan virus disease
Neuroinvasive 1 0.00 1 0.00 7 0.01 12 0.02 21
Non-neuroinvasive
St. Louis encephalitis virus disease
Neuroinvasive 1 0.00 4 0.01 5
Non-neuroinvasive 1 0.00 2 0.00 3
West Nile virus disease
Neuroinvasive 3 0.02 16 0.04 48 0.11 153 0.23 642 0.62 794 1.51 1,656
Non-neuroinvasive 1 0.03 3 0.02 11 0.03 58 0.13 206 0.31 481 0.46 229 0.44 989
Western equine encephalitis virus disease
Neuroinvasive
Non-neuroinvasive
Babesiosis
Total 5 0.16 3 0.02 30 0.09 44 0.12 159 0.28 878 1.02 1,041 2.39 2,160
Confirmed 5 0.16 2 0.02 19 0.06 34 0.10 127 0.23 745 0.87 929 2.13 1,861
Probable 1 0.01 11 0.03 10 0.03 32 0.06 133 0.15 112 0.26 299
Botulism
Total 157 4.08 2 0.00 3 0.01 18 0.03 37 0.04 8 0.02 225
Foodborne 2 0.00 1 0.00 4 0.01 5 0.00 5 0.01 17
Infant 157 4.08 157
Other (wound & unspecified) 2 0.00 14 0.02 32 0.03 3 0.01 51
Brucellosis 1 0.01 12 0.03 11 0.03 29 0.04 52 0.05 33 0.06 138
Campylobacteriosis 1,803 46.85 6,050 37.90 5,266 12.82 7,695 17.91 12,878 19.15 22,751 21.96 13,692 26.11 65 70,200
Chancroid 1 0.00 1 0.00 1 0.00 3
Chlamydia trachomatis infection 434 11.28 62 0.39 11,049 26.90 1,087,277 2,530.27 565,787 841.18 89,516 86.39 2,331 4.45 2,212 1,758,668
Cholera 1 0.03 1 0.01 1 0.00 1 0.00 7 0.01 3 0.01 14
Coccidioidomycosis * 15 0.93 80 1.20 517 3.01 1,367 7.64 3,168 11.40 6,396 15.10 4,031 18.87 37 15,611
Cryptosporidiosis
Total 118 3.07 1,403 8.79 1,360 3.31 1,952 4.54 3,117 4.63 3,026 2.92 1,550 2.96 7 12,533
Confirmed 94 2.44 1,078 6.75 1,019 2.48 1,470 3.42 2,326 3.46 2,122 2.05 866 1.65 5 8,980
Probable 24 0.62 325 2.04 341 0.83 482 1.12 791 1.18 904 0.87 684 1.30 2 3,553
Cyclosporiasis 3 0.09 9 0.06 45 0.12 257 0.67 828 1.37 1,806 1.95 547 1.17 24 3,519
Dengue virus infections 
Dengue 2 0.05 1 0.01 29 0.07 45 0.10 110 0.16 183 0.18 54 0.10 424
Dengue-like illness 2 0.01 1 0.00 4 0.01 13 0.02 16 0.02 5 0.01 41
Severe dengue 2 0.00 5 0.01 2 0.00 9
Diphtheria 1 0.00 1
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection 12 0.08 82 0.21 126 0.30 360 0.56 1,747 1.75 1,674 3.31 7 4,008
Ehrlichia chaffeensis infection 12 0.08 55 0.14 110 0.27 190 0.29 798 0.80 634 1.25 1,799
Ehrlichia ewingii infection 2 0.00 14 0.01 17 0.03 33
Undetermined ehrlichiosis/anaplasmosis 1 0.01 15 0.04 22 0.05 43 0.07 98 0.10 103 0.21 1 283
Giardiasis 104 3.51 1,163 9.46 1,380 4.36 1,742 5.22 3,614 6.87 5,369 6.58 2,166 5.15 10 15,548
Gonorrhea 105 2.73 119 0.75 2,794 6.80 249,081 579.65 258,291 384.01 70,314 67.86 2,332 4.45 369 583,405
Haemophilus influenzae, invasive disease
All ages, all serotypes 392 10.19 234 1.47 126 0.31 138 0.32 384 0.57 1,510 1.46 2,785 5.31 4 5,573
Age <5 years
Serotype b 27 0.70 11 0.07 38
Non-b serotype 100 2.60 91 0.57 191
Nontypeable 151 3.92 71 0.44 222
Unknown serotype 114 2.96 61 0.38 175
Hansen's disease 3 0.01 11 0.02 32 0.03 25 0.05 19 90
Hantavirus infection, non-hantavirus pulmonary syndrome 1 0.00 1 0.00 2
Hantavirus pulmonary syndrome 1 0.00 1 0.00 5 0.01 9 0.01 2 0.00 18
Hemolytic uremic syndrome post-diarrheal 9 0.24 159 1.02 95 0.24 25 0.06 20 0.03 34 0.03 33 0.06 1 376
Hepatitis §
A, acute 5 0.13 26 0.16 65 0.16 992 2.31 6,227 9.26 4,563 4.40 590 1.13 6 12,474
B, acute 3 0.08 1 0.00 105 0.25 1,034 1.55 1,937 1.88 240 0.46 2 3,322
B, perinatal infection 18 0.47 5 0.13 23
C, acute 8 0.22 1 0.01 4 0.01 686 1.69 2,544 3.99 1,333 1.35 181 0.36 11 4,768
Confirmed 6 0.16 3 0.01 558 1.37 1,893 2.97 1,004 1.02 151 0.30 6 3,621
Probable 2 0.05 1 0.01 1 0.00 128 0.31 651 1.02 329 0.33 30 0.06 5 1,147
C, perinatal infection 95 2.76 117 0.82 2 214
Human immunodeficiency virus diagnoses 39 1.01 13 0.08 51 0.12 6,609 15.38 15,436 22.95 10,065 9.71 786 1.50 32,999
Influenza-associated pediatric mortality 20 0.52 48 0.30 74 0.18 17 0.14 159
Invasive pneumococcal disease 
All ages 374 13.09 691 5.82 494 1.62 319 1.00 1,599 3.23 8,236 10.63 8,130 20.46 14 19,857
Confirmed 357 12.49 673 5.67 468 1.53 310 0.97 1,575 3.18 8,162 10.54 8,060 20.28 14 19,619
Probable 17 0.59 18 0.15 26 0.09 9 0.03 24 0.05 74 0.10 70 0.18 238
Age <5 years 395 12.83 721 5.64 1,116
Confirmed 375 12.18 703 5.50 1,078
Probable 20 0.65 18 0.14 38
Legionellosis 1 0.03 3 0.01 82 0.19 704 1.05 4,890 4.72 4,250 8.11 3 9,933
Leptospirosis 4 0.01 21 0.06 22 0.04 40 0.05 4 0.01 91
Listeriosis 42 1.09 5 0.03 2 0.00 22 0.05 85 0.13 199 0.19 509 0.97 864
Lyme disease
Total 27 0.70 1,149 7.23 5,089 12.44 2,938 6.86 4,337 6.48 11,738 11.38 8,339 15.98 49 33,666
Confirmed 20 0.52 966 6.08 3,925 9.60 1,893 4.42 2,908 4.34 8,272 8.02 5,540 10.62 34 23,558
Probable 7 0.18 183 1.15 1,164 2.85 1,045 2.44 1,429 2.13 3,466 3.36 2,799 5.37 15 10,108
Malaria 5 0.13 57 0.36 161 0.39 241 0.56 469 0.70 685 0.66 130 0.25 1,748
Measles
Total 44 1.14 117 0.73 83 0.20 56 0.13 36 0.05 39 0.04 375
Indigenous 35 0.91 96 0.60 72 0.18 40 0.09 24 0.04 29 0.03 296
Imported 9 0.23 21 0.13 11 0.03 16 0.04 12 0.02 10 0.01 79
Meningococcal disease
All serogroups 32 0.83 29 0.18 14 0.03 41 0.10 47 0.07 92 0.09 72 0.14 327
Serogroups ACWY 5 0.13 10 0.06 5 0.01 1 0.00 17 0.03 34 0.03 28 0.05 100
Serogroup B 16 0.42 9 0.06 3 0.01 16 0.04 7 0.01 17 0.02 13 0.02 81
Other serogroups 2 0.05 2 0.00 5 0.01 6 0.01 3 0.00 5 0.01 23
Unknown serogroup 9 0.23 10 0.06 4 0.01 19 0.04 17 0.03 38 0.04 26 0.05 123
Mumps 15 0.39 142 0.89 334 0.81 720 1.68 769 1.14 444 0.43 87 0.17 4 2,515
Novel Influenza A virus infections 1 0.01 3 0.01 2 0.00 8 14
Paratyphoid fever ** 10 0.06 20 0.05 19 0.04 37 0.06 35 0.03 12 0.02 133
Pertussis 1,995 51.84 2,431 15.23 4,742 11.54 3,212 7.47 925 1.38 1,629 1.57 652 1.24 23 15,609
Plague 1 0.00 1
Poliomyelitis, paralytic
Poliovirus infection, nonparalytic
Psittacosis 1 0.00 6 0.01 10 0.01 5 0.01 22
Q fever
Total 3 0.01 12 0.03 24 0.04 109 0.11 67 0.13 215
Acute 2 0.00 10 0.02 19 0.03 95 0.09 52 0.10 178
Chronic 1 0.00 2 0.00 5 0.01 14 0.01 15 0.03 37
Rabies
Human 1 0.00 1 0.00 1 0.00 3
Rubella 1 0.03 3 0.00 4
Rubella, congenital syndrome
Salmonellosis (excluding paratyphoid fever and typhoid fever) †† 5,540 143.96 7,845 49.15 5,971 14.54 5,410 12.59 9,069 13.48 16,357 15.79 10,747 20.50 60 60,999
Severe acute respiratory syndrome-associated coronavirus disease
Shiga toxin-producing Escherichia coli (STEC) 600 15.59 2,895 18.14 1,853 4.51 2,274 5.29 2,627 3.91 3,223 3.11 2,486 4.74 38 15,996
Shigellosis 252 6.55 2,766 17.33 2,497 6.08 1,474 3.43 3,842 5.71 4,031 3.89 1,393 2.66 78 16,333
Smallpox
Spotted fever rickettsiosis
Total 2 0.05 69 0.44 233 0.57 405 0.95 1,013 1.52 2,545 2.47 1,275 2.45 2 5,544
Confirmed 5 0.03 7 0.02 2 0.00 20 0.03 59 0.06 31 0.06 124
Probable 2 0.05 64 0.40 226 0.55 403 0.94 993 1.49 2,486 2.41 1,244 2.39 2 5,420
Streptococcal toxic shock syndrome 4 0.16 6 0.06 13 0.05 14 0.05 52 0.12 153 0.23 129 0.38 371
Syphilis
Total, all stages §§ 1,311 34.07 3 0.02 57 0.14 21,790 50.71 57,325 85.23 32,307 31.18 2,225 4.24 27 115,045
Congenital 1,306 34.44 1,306
Primary and secondary 2 0.01 20 0.05 7,758 18.05 17,819 26.49 9,017 8.70 437 0.83 10 35,063
Tetanus 1 0.00 5 0.01 4 0.01 5 0.00 3 0.01 5 23
Toxic shock syndrome (other than Streptococcal) 2 0.02 13 0.05 12 0.04 1 0.00 2 0.00 3 0.01 33
Trichinellosis 1 0.00 1
Tuberculosis 48 1.25 138 0.86 186 0.45 874 2.03 2,094 3.11 3,328 3.21 2,354 4.49 3 9,025
Tularemia 5 0.03 28 0.07 15 0.03 39 0.06 92 0.09 50 0.10 229
Typhoid fever 2 0.05 42 0.26 76 0.19 77 0.18 113 0.17 73 0.07 18 0.03 401
Vancomycin-intermediate Staphylococcus aureus 1 0.01 1 0.00 3 0.01 6 0.01 33 0.04 41 0.10 85
Vancomycin-resistant Staphylococcus aureus
Varicella morbidity 754 23.83 1,795 13.69 2,738 8.13 769 2.18 840 1.52 651 0.77 127 0.30 527 8,201
Varicella mortality U U U U U U U U U U U U U U U U
Vibriosis
Total 29 0.77 69 0.44 151 0.37 192 0.45 551 0.83 1,169 1.14 795 1.54 8 2,964
Confirmed 3 0.08 24 0.15 114 0.28 108 0.26 347 0.52 750 0.73 475 0.92 1 1,822
Probable 26 0.69 45 0.29 37 0.09 84 0.20 204 0.31 419 0.41 320 0.62 7 1,142
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus
Ebola virus
Guanarito virus
Junin virus
Lassa virus
Lujo virus
Machupo virus
Marburg virus
Sabia virus
Yellow fever
Zika virus
Zika virus disease, congenital ¶¶ 2 0.05 2
Zika virus disease, non-congenital 11 0.03 35 0.05 23 0.02 10 0.02 79
Zika virus infection, congenital ¶¶ 7 0.18 7
Zika virus infection, non-congenital 1 0.00 72 0.17 152 0.23 19 0.02 1 0.00 245
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • U: Unavailable — The data are unavailable.
  • * Reportable in <25 states.
  • † Counts include confirmed and probable dengue cases.
  • § Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/SurveillanceRpts.htm.
  • ¶ Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years.
  • ** Prior to 2018, cases of paratyphoid fever were considered salmonellosis.
  • †† Prior to 2018, cases of paratyphoid fever were included as salmonellosis, but beginning in 2018 they are being published as paratyphoid fever.
  • §§ Includes the following categories: primary; secondary; early non-primary non-secondary (includes cases previously reported as early latent); and unknown duration or late (includes cases previously reported as late latent syphilis and cases previously reported as late syphilis with clinical manifestations).
  • ¶¶ Data reported to ArboNET using the national surveillance case definition for congenital Zika virus infection (CSTE Position Statement 16-ID-01).

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