Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 4. Annual reported cases of notifiable diseases and rates per 100,000, by age, excluding U.S. Territories - - United States, 2018
Disease <1 yr 1-4 yrs 5-14 yrs 15-24 yrs 25-39 yrs 40-64 yrs ≥65 yrs Age not stated Total
No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. No.
Anthrax — — — — — — — — 1 0.00 — — — — — 1
Arboviral diseases
Chikungunya virus disease 1 0.03 2 0.01 8 0.02 9 0.02 41 0.06 45 0.04 11 0.02 — 117
Eastern equine encephalitis virus disease
Neuroinvasive — — — — — — — — — — 3 0.00 3 0.01 — 6
Non-neuroinvasive — — — — — — — — — — — — — — — —
Jamestown Canyon virus disease
Neuroinvasive — — — — — — 4 0.01 4 0.01 10 0.01 7 0.01 — 25
Non-neuroinvasive — — — — — — 2 0.00 — — 10 0.01 4 0.01 — 16
La Crosse virus disease
Neuroinvasive 2 0.05 14 0.09 58 0.14 4 0.01 2 0.00 2 0.00 1 0.00 — 83
Non-neuroinvasive — — — — 3 0.01 — — — — — — — — — 3
Powassan virus disease
Neuroinvasive — — — — 1 0.00 — — 1 0.00 7 0.01 12 0.02 — 21
Non-neuroinvasive — — — — — — — — — — — — — — — —
St. Louis encephalitis virus disease
Neuroinvasive — — — — — — — — — — 1 0.00 4 0.01 — 5
Non-neuroinvasive — — — — — — — — 1 0.00 2 0.00 — — — 3
West Nile virus disease
Neuroinvasive — — 3 0.02 16 0.04 48 0.11 153 0.23 642 0.62 794 1.51 — 1,656
Non-neuroinvasive 1 0.03 3 0.02 11 0.03 58 0.13 206 0.31 481 0.46 229 0.44 — 989
Western equine encephalitis virus disease
Neuroinvasive — — — — — — — — — — — — — — — —
Non-neuroinvasive — — — — — — — — — — — — — — — —
Babesiosis
Total 5 0.16 3 0.02 30 0.09 44 0.12 159 0.28 878 1.02 1,041 2.39 — 2,160
Confirmed 5 0.16 2 0.02 19 0.06 34 0.10 127 0.23 745 0.87 929 2.13 — 1,861
Probable — — 1 0.01 11 0.03 10 0.03 32 0.06 133 0.15 112 0.26 — 299
Botulism
Total 157 4.08 — — 2 0.00 3 0.01 18 0.03 37 0.04 8 0.02 — 225
Foodborne — — — — 2 0.00 1 0.00 4 0.01 5 0.00 5 0.01 — 17
Infant 157 4.08 — — — — — — — — — — — — — 157
Other (wound & unspecified) — — — — — — 2 0.00 14 0.02 32 0.03 3 0.01 — 51
Brucellosis — — 1 0.01 12 0.03 11 0.03 29 0.04 52 0.05 33 0.06 — 138
Campylobacteriosis 1,803 46.85 6,050 37.90 5,266 12.82 7,695 17.91 12,878 19.15 22,751 21.96 13,692 26.11 65 70,200
Chancroid — — — — — — 1 0.00 1 0.00 1 0.00 — — — 3
Chlamydia trachomatis infection 434 11.28 62 0.39 11,049 26.90 1,087,277 2,530.27 565,787 841.18 89,516 86.39 2,331 4.45 2,212 1,758,668
Cholera 1 0.03 1 0.01 1 0.00 — — 1 0.00 7 0.01 3 0.01 — 14
Coccidioidomycosis * 15 0.93 80 1.20 517 3.01 1,367 7.64 3,168 11.40 6,396 15.10 4,031 18.87 37 15,611
Cryptosporidiosis
Total 118 3.07 1,403 8.79 1,360 3.31 1,952 4.54 3,117 4.63 3,026 2.92 1,550 2.96 7 12,533
Confirmed 94 2.44 1,078 6.75 1,019 2.48 1,470 3.42 2,326 3.46 2,122 2.05 866 1.65 5 8,980
Probable 24 0.62 325 2.04 341 0.83 482 1.12 791 1.18 904 0.87 684 1.30 2 3,553
Cyclosporiasis 3 0.09 9 0.06 45 0.12 257 0.67 828 1.37 1,806 1.95 547 1.17 24 3,519
Dengue virus infections †
Dengue 2 0.05 1 0.01 29 0.07 45 0.10 110 0.16 183 0.18 54 0.10 — 424
Dengue-like illness — — 2 0.01 1 0.00 4 0.01 13 0.02 16 0.02 5 0.01 — 41
Severe dengue — — — — — — 2 0.00 5 0.01 2 0.00 — — — 9
Diphtheria — — — — 1 0.00 — — — — — — — — — 1
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection — — 12 0.08 82 0.21 126 0.30 360 0.56 1,747 1.75 1,674 3.31 7 4,008
Ehrlichia chaffeensis infection — — 12 0.08 55 0.14 110 0.27 190 0.29 798 0.80 634 1.25 — 1,799
Ehrlichia ewingii infection — — — — — — — — 2 0.00 14 0.01 17 0.03 — 33
Undetermined ehrlichiosis/anaplasmosis — — 1 0.01 15 0.04 22 0.05 43 0.07 98 0.10 103 0.21 1 283
Giardiasis 104 3.51 1,163 9.46 1,380 4.36 1,742 5.22 3,614 6.87 5,369 6.58 2,166 5.15 10 15,548
Gonorrhea 105 2.73 119 0.75 2,794 6.80 249,081 579.65 258,291 384.01 70,314 67.86 2,332 4.45 369 583,405
Haemophilus influenzae, invasive disease
All ages, all serotypes 392 10.19 234 1.47 126 0.31 138 0.32 384 0.57 1,510 1.46 2,785 5.31 4 5,573
Age <5 years
Serotype b 27 0.70 11 0.07 — — — — — — — — — — — 38
Non-b serotype 100 2.60 91 0.57 — — — — — — — — — — — 191
Nontypeable 151 3.92 71 0.44 — — — — — — — — — — — 222
Unknown serotype 114 2.96 61 0.38 — — — — — — — — — — — 175
Hansen's disease — — — — — — 3 0.01 11 0.02 32 0.03 25 0.05 19 90
Hantavirus infection, non-hantavirus pulmonary syndrome — — — — — — 1 0.00 — — 1 0.00 — — — 2
Hantavirus pulmonary syndrome — — — — 1 0.00 1 0.00 5 0.01 9 0.01 2 0.00 — 18
Hemolytic uremic syndrome post-diarrheal 9 0.24 159 1.02 95 0.24 25 0.06 20 0.03 34 0.03 33 0.06 1 376
Hepatitis §
A, acute 5 0.13 26 0.16 65 0.16 992 2.31 6,227 9.26 4,563 4.40 590 1.13 6 12,474
B, acute 3 0.08 — — 1 0.00 105 0.25 1,034 1.55 1,937 1.88 240 0.46 2 3,322
B, perinatal infection 18 0.47 5 0.13 — — — — — — — — — — — 23
C, acute 8 0.22 1 0.01 4 0.01 686 1.69 2,544 3.99 1,333 1.35 181 0.36 11 4,768
Confirmed 6 0.16 — — 3 0.01 558 1.37 1,893 2.97 1,004 1.02 151 0.30 6 3,621
Probable 2 0.05 1 0.01 1 0.00 128 0.31 651 1.02 329 0.33 30 0.06 5 1,147
C, perinatal infection 95 2.76 117 0.82 — — — — — — — — — — 2 214
Human immunodeficiency virus diagnoses 39 1.01 13 0.08 51 0.12 6,609 15.38 15,436 22.95 10,065 9.71 786 1.50 — 32,999
Influenza-associated pediatric mortality 20 0.52 48 0.30 74 0.18 17 0.14 — — — — — — — 159
Invasive pneumococcal disease 
All ages 374 13.09 691 5.82 494 1.62 319 1.00 1,599 3.23 8,236 10.63 8,130 20.46 14 19,857
Confirmed 357 12.49 673 5.67 468 1.53 310 0.97 1,575 3.18 8,162 10.54 8,060 20.28 14 19,619
Probable 17 0.59 18 0.15 26 0.09 9 0.03 24 0.05 74 0.10 70 0.18 — 238
Age <5 years 395 12.83 721 5.64 — — — — — — — — — — — 1,116
Confirmed 375 12.18 703 5.50 — — — — — — — — — — — 1,078
Probable 20 0.65 18 0.14 — — — — — — — — — — — 38
Legionellosis 1 0.03 — — 3 0.01 82 0.19 704 1.05 4,890 4.72 4,250 8.11 3 9,933
Leptospirosis — — — — 4 0.01 21 0.06 22 0.04 40 0.05 4 0.01 — 91
Listeriosis 42 1.09 5 0.03 2 0.00 22 0.05 85 0.13 199 0.19 509 0.97 — 864
Lyme disease
Total 27 0.70 1,149 7.23 5,089 12.44 2,938 6.86 4,337 6.48 11,738 11.38 8,339 15.98 49 33,666
Confirmed 20 0.52 966 6.08 3,925 9.60 1,893 4.42 2,908 4.34 8,272 8.02 5,540 10.62 34 23,558
Probable 7 0.18 183 1.15 1,164 2.85 1,045 2.44 1,429 2.13 3,466 3.36 2,799 5.37 15 10,108
Malaria 5 0.13 57 0.36 161 0.39 241 0.56 469 0.70 685 0.66 130 0.25 — 1,748
Measles
Total 44 1.14 117 0.73 83 0.20 56 0.13 36 0.05 39 0.04 — — — 375
Indigenous 35 0.91 96 0.60 72 0.18 40 0.09 24 0.04 29 0.03 — — — 296
Imported 9 0.23 21 0.13 11 0.03 16 0.04 12 0.02 10 0.01 — — — 79
Meningococcal disease
All serogroups 32 0.83 29 0.18 14 0.03 41 0.10 47 0.07 92 0.09 72 0.14 — 327
Serogroups ACWY 5 0.13 10 0.06 5 0.01 1 0.00 17 0.03 34 0.03 28 0.05 — 100
Serogroup B 16 0.42 9 0.06 3 0.01 16 0.04 7 0.01 17 0.02 13 0.02 — 81
Other serogroups 2 0.05 — — 2 0.00 5 0.01 6 0.01 3 0.00 5 0.01 — 23
Unknown serogroup 9 0.23 10 0.06 4 0.01 19 0.04 17 0.03 38 0.04 26 0.05 — 123
Mumps 15 0.39 142 0.89 334 0.81 720 1.68 769 1.14 444 0.43 87 0.17 4 2,515
Novel Influenza A virus infections — — 1 0.01 3 0.01 2 0.00 — — — — — — 8 14
Paratyphoid fever ** — — 10 0.06 20 0.05 19 0.04 37 0.06 35 0.03 12 0.02 — 133
Pertussis 1,995 51.84 2,431 15.23 4,742 11.54 3,212 7.47 925 1.38 1,629 1.57 652 1.24 23 15,609
Plague — — — — 1 0.00 — — — — — — — — — 1
Poliomyelitis, paralytic — — — — — — — — — — — — — — — —
Poliovirus infection, nonparalytic — — — — — — — — — — — — — — — —
Psittacosis — — — — — — 1 0.00 6 0.01 10 0.01 5 0.01 — 22
Q fever
Total — — — — 3 0.01 12 0.03 24 0.04 109 0.11 67 0.13 — 215
Acute — — — — 2 0.00 10 0.02 19 0.03 95 0.09 52 0.10 — 178
Chronic — — — — 1 0.00 2 0.00 5 0.01 14 0.01 15 0.03 — 37
Rabies
Human — — — — 1 0.00 — — — — 1 0.00 1 0.00 — 3
Rubella 1 0.03 — — — — — — 3 0.00 — — — — — 4
Rubella, congenital syndrome — — — — — — — — — — — — — — — —
Salmonellosis (excluding paratyphoid fever and typhoid fever) †† 5,540 143.96 7,845 49.15 5,971 14.54 5,410 12.59 9,069 13.48 16,357 15.79 10,747 20.50 60 60,999
Severe acute respiratory syndrome-associated coronavirus disease — — — — — — — — — — — — — — — —
Shiga toxin-producing Escherichia coli (STEC) 600 15.59 2,895 18.14 1,853 4.51 2,274 5.29 2,627 3.91 3,223 3.11 2,486 4.74 38 15,996
Shigellosis 252 6.55 2,766 17.33 2,497 6.08 1,474 3.43 3,842 5.71 4,031 3.89 1,393 2.66 78 16,333
Smallpox — — — — — — — — — — — — — — — —
Spotted fever rickettsiosis
Total 2 0.05 69 0.44 233 0.57 405 0.95 1,013 1.52 2,545 2.47 1,275 2.45 2 5,544
Confirmed — — 5 0.03 7 0.02 2 0.00 20 0.03 59 0.06 31 0.06 — 124
Probable 2 0.05 64 0.40 226 0.55 403 0.94 993 1.49 2,486 2.41 1,244 2.39 2 5,420
Streptococcal toxic shock syndrome 4 0.16 6 0.06 13 0.05 14 0.05 52 0.12 153 0.23 129 0.38 — 371
Syphilis
Total, all stages §§ 1,311 34.07 3 0.02 57 0.14 21,790 50.71 57,325 85.23 32,307 31.18 2,225 4.24 27 115,045
Congenital 1,306 34.44 — — — — — — — — — — — — — 1,306
Primary and secondary — — 2 0.01 20 0.05 7,758 18.05 17,819 26.49 9,017 8.70 437 0.83 10 35,063
Tetanus — — — — 1 0.00 5 0.01 4 0.01 5 0.00 3 0.01 5 23
Toxic shock syndrome (other than Streptococcal) — — 2 0.02 13 0.05 12 0.04 1 0.00 2 0.00 3 0.01 — 33
Trichinellosis — — — — — — — — — — 1 0.00 — — — 1
Tuberculosis 48 1.25 138 0.86 186 0.45 874 2.03 2,094 3.11 3,328 3.21 2,354 4.49 3 9,025
Tularemia — — 5 0.03 28 0.07 15 0.03 39 0.06 92 0.09 50 0.10 — 229
Typhoid fever 2 0.05 42 0.26 76 0.19 77 0.18 113 0.17 73 0.07 18 0.03 — 401
Vancomycin-intermediate Staphylococcus aureus — — 1 0.01 1 0.00 3 0.01 6 0.01 33 0.04 41 0.10 — 85
Vancomycin-resistant Staphylococcus aureus — — — — — — — — — — — — — — — —
Varicella morbidity 754 23.83 1,795 13.69 2,738 8.13 769 2.18 840 1.52 651 0.77 127 0.30 527 8,201
Varicella mortality U U U U U U U U U U U U U U U U
Vibriosis
Total 29 0.77 69 0.44 151 0.37 192 0.45 551 0.83 1,169 1.14 795 1.54 8 2,964
Confirmed 3 0.08 24 0.15 114 0.28 108 0.26 347 0.52 750 0.73 475 0.92 1 1,822
Probable 26 0.69 45 0.29 37 0.09 84 0.20 204 0.31 419 0.41 320 0.62 7 1,142
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus — — — — — — — — — — — — — — — —
Ebola virus — — — — — — — — — — — — — — — —
Guanarito virus — — — — — — — — — — — — — — — —
Junin virus — — — — — — — — — — — — — — — —
Lassa virus — — — — — — — — — — — — — — — —
Lujo virus — — — — — — — — — — — — — — — —
Machupo virus — — — — — — — — — — — — — — — —
Marburg virus — — — — — — — — — — — — — — — —
Sabia virus — — — — — — — — — — — — — — — —
Yellow fever — — — — — — — — — — — — — — — —
Zika virus
Zika virus disease, congenital ¶¶ 2 0.05 — — — — — — — — — — — — — 2
Zika virus disease, non-congenital — — — — — — 11 0.03 35 0.05 23 0.02 10 0.02 — 79
Zika virus infection, congenital ¶¶ 7 0.18 — — — — — — — — — — — — — 7
Zika virus infection, non-congenital — — — — 1 0.00 72 0.17 152 0.23 19 0.02 1 0.00 — 245
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • U: Unavailable — The data are unavailable.
  • * Reportable in <25 states.
  • † Counts include confirmed and probable dengue cases.
  • § Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/SurveillanceRpts.htm.
  • ¶ Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years.
  • ** Prior to 2018, cases of paratyphoid fever were considered salmonellosis.
  • †† Prior to 2018, cases of paratyphoid fever were included as salmonellosis, but beginning in 2018 they are being published as paratyphoid fever.
  • §§ Includes the following categories: primary; secondary; early non-primary non-secondary (includes cases previously reported as early latent); and unknown duration or late (includes cases previously reported as late latent syphilis and cases previously reported as late syphilis with clinical manifestations).
  • ¶¶ Data reported to ArboNET using the national surveillance case definition for congenital Zika virus infection (CSTE Position Statement 16-ID-01).
Notes:
  1. These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables.
  2. The list of nationally notifiable infectious diseases and conditions for 2018 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2018" for the notifiable condition list year, checking "infectious" conditions, and clicking "Get Notifiable List by Year". This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved in 2017 by CSTE for national surveillance, that were implemented in January 2018, including updated surveillance case definitions for anthrax, shiga toxin-producing Escherichia coli, and syphilis. Perinatal hepatitis c virus infection became a new nationally notifiable condition in 2018. While Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae (CP-CRE) was added to the list of nationally notifiable diseases in 2018, reporting jurisdictions could not submit data for this condition since Office of Management and Budget Paperwork Reduction Act approval was pending during 2018. Publication criteria for the finalized 2018 data are available at https://wonder.cdc.gov/nndss/documents/2018_NNDSS _Publication_Criteria_07122019_updated_09230219.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  3. Annual tables for 2016 and later years are available on CDC WONDER.
  4. Annual summary reports from 1993-2015 are available as published in the MMWR.
  5. NNDSS annual tables since 1952 are available at CDC Stacks (once in CDC Stacks select "Annual Reports" in the "Genre" box to the left).
  6. For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a nationally notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations.

    Population estimates for incidence rates are July 1st, 2018 estimates obtained from the National Center for Health Statistics (NCHS) postcensal estimates of the resident population of the United States for April 1, 2010 - July 1, 2018, by year, county, single year of age (range: 0 to 85 years), bridged-race (white, black or African American, American Indian or Alaska Native, Asian, or Pacific Islander), Hispanic ethnicity (not Hispanic or Latino, Hispanic or Latino), and sex (Vintage 2018), prepared under a collaborative arrangement with the U.S. Census Bureau. Population estimates for states released June 25, 2019 are available at https://www.cdc.gov/nchs/nvss/bridged_race/data_documentation.htm. Population estimates for territories are the 2018 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on June 26, 2019 at https://www.census.gov/data-tools/demo/idb/informationGateway.php. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.

    Age restrictions in the numerator and denominator are applied for the following childhood conditions:

    • Zika virus disease, congenital (age restriction in numerator and denominator is <1 year)
    • Zika virus infection, congenital (age restriction in numerator and denominator is <1 year)
    • Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years)
    • Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years)
    • Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years)
    • Infant botulism (age restriction in numerator and denominator is <1 year)
    • Congenital rubella syndrome (age restriction in numerator and denominator is <1 year)
    • Perinatal Hepatitis B infection (age restriction in numerator is ≤24 months, denominator is <24 months)
    • Perinatal Hepatitis C infection (age restriction in numerator is ≤36 months, denominator is <36 months)

    Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2018 (National Center for Health Statistics Natality 2018, as compiled from data provided by the Vital Statistics Cooperative Program). The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases. Congenital syphilis data are published in Syphilis Statistics in the Sexually Transmitted Diseases (STD) surveillance report (https://www.cdc.gov/std/syphilis/stats.htm) and in the historical archives of the STD surveillance report (https://www.cdc.gov/std/stats/archive.htm). The STD surveillance report (https://www.cdc.gov/std/syphilis/stats.htm) updates congenital syphilis cases and rates over time.

  7. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC).
Suggested Citation: Acknowledgement:
  • CDC acknowledges the Local, State, and Territorial Health Departments that collected the data from a range of case ascertainment sources (e.g., health-care providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System.