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Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 5. Annual reported cases of notifiable diseases and rates per 100,000, by sex, excluding U.S. Territories - - United States, 2018
Disease Female Male Sex not stated Total
No. Rate No. Rate No. No.
Anthrax 1 0.00 1
Arboviral diseases
Chikungunya virus disease 79 0.05 38 0.02 117
Eastern equine encephalitis virus disease
Neuroinvasive 3 0.00 3 0.00 6
Non-neuroinvasive
Jamestown Canyon virus disease
Neuroinvasive 5 0.00 20 0.01 25
Non-neuroinvasive 1 0.00 15 0.01 16
La Crosse virus disease
Neuroinvasive 43 0.03 40 0.02 83
Non-neuroinvasive 3 0.00 3
Powassan virus disease
Neuroinvasive 7 0.00 14 0.01 21
Non-neuroinvasive
St. Louis encephalitis virus disease
Neuroinvasive 2 0.00 3 0.00 5
Non-neuroinvasive 2 0.00 1 0.00 3
West Nile virus disease
Neuroinvasive 604 0.36 1,053 0.65 1,657
Non-neuroinvasive 405 0.24 584 0.36 989
Western equine encephalitis virus disease
Neuroinvasive
Non-neuroinvasive
Babesiosis
Total 765 0.55 1,393 1.04 2 2,160
Confirmed 651 0.47 1,208 0.90 2 1,861
Probable 114 0.08 185 0.14 299
Botulism
Total 112 0.07 113 0.07 225
Foodborne 11 0.01 6 0.00 17
Infant 86 4.58 71 3.61 157
Other (wound & unspecified) 15 0.01 36 0.02 51
Brucellosis 56 0.03 82 0.05 138
Campylobacteriosis 33,351 20.09 36,693 22.77 156 70,200
Chancroid 3 0.00 3
Chlamydia trachomatis infection 1,145,063 689.64 610,447 378.86 3,158 1,758,668
Cholera 5 0.00 9 0.01 14
Coccidioidomycosis * 7,032 10.33 8,552 12.82 27 15,611
Cryptosporidiosis
Total 6,476 3.90 6,038 3.75 19 12,533
Confirmed 4,540 2.73 4,428 2.75 12 8,980
Probable 1,936 1.17 1,610 1.00 7 3,553
Cyclosporiasis 1,924 1.30 1,594 1.11 1 3,519
Dengue virus infections 
Dengue 215 0.13 209 0.13 424
Dengue-like illness 19 0.01 22 0.01 41
Severe dengue 8 0.00 1 0.00 9
Diphtheria 1 0.00 1
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection 1,575 0.98 2,430 1.57 3 4,008
Ehrlichia chaffeensis infection 803 0.50 992 0.64 4 1,799
Ehrlichia ewingii infection 10 0.01 23 0.01 33
Undetermined ehrlichiosis/anaplasmosis 127 0.08 156 0.10 283
Giardiasis 5,957 4.58 9,540 7.55 51 15,548
Gonorrhea 241,074 145.19 341,401 211.88 930 583,405
Haemophilus influenzae, invasive disease
All ages, all serotypes 2,972 1.79 2,568 1.59 33 5,573
Age <5 years
Serotype b 16 0.17 22 0.22 38
Non-b serotype 76 0.79 115 1.13 191
Nontypeable 97 1.00 123 1.21 2 222
Unknown serotype 72 0.74 102 1.01 1 175
Hansen's disease 30 0.02 43 0.03 17 90
Hantavirus infection, non-hantavirus pulmonary syndrome 1 0.00 1 0.00 2
Hantavirus pulmonary syndrome 10 0.01 8 0.01 18
Hemolytic uremic syndrome post-diarrheal 220 0.14 156 0.10 376
Hepatitis §
A, acute 4,951 2.98 7,497 4.65 26 12,474
B, acute 1,260 0.76 2,050 1.28 12 3,322
B, perinatal infection 15 0.40 8 0.20 23
C, acute 2,058 1.31 2,706 1.77 4 4,768
Confirmed 1,605 1.02 2,012 1.32 4 3,621
Probable 453 0.29 694 0.45 1,147
C, perinatal infection 117 0.08 97 0.07 214
Human immunodeficiency virus diagnoses 6,286 3.79 26,713 16.58 32,999
Influenza-associated pediatric mortality 90 0.25 69 0.18 159
Invasive pneumococcal disease 
All ages 9,413 7.59 10,328 8.61 116 19,857
Confirmed 9,291 7.49 10,212 8.52 116 19,619
Probable 122 0.10 116 0.10 238
Age <5 years 477 0.36 631 0.49 8 1,116
Confirmed 463 5.97 607 7.48 8 1,078
Probable 14 0.18 24 0.30 38
Legionellosis 3,637 2.19 6,289 3.90 7 9,933
Leptospirosis 21 0.02 70 0.05 91
Listeriosis 452 0.27 406 0.25 6 864
Lyme disease
Total 14,048 8.50 19,092 11.90 526 33,666
Confirmed 9,708 5.87 13,346 8.32 504 23,558
Probable 4,340 2.63 5,746 3.58 22 10,108
Malaria 659 0.40 1,085 0.67 4 1,748
Measles
Total 182 0.11 193 0.12 375
Indigenous 147 0.09 149 0.09 296
Imported 35 0.02 44 0.03 79
Meningococcal disease
All serogroups 161 0.10 166 0.10 327
Serogroups ACWY 46 0.03 54 0.03 100
Serogroup B 50 0.03 31 0.02 81
Other serogroups 10 0.01 13 0.01 23
Unknown serogroup 55 0.03 68 0.04 123
Mumps 1,032 0.62 1,477 0.92 6 2,515
Novel Influenza A virus infections 5 0.00 9 0.01 14
Paratyphoid fever ** 70 0.04 63 0.04 133
Pertussis 8,485 5.11 7,064 4.38 60 15,609
Plague 1 0.00 1
Poliomyelitis, paralytic
Poliovirus infection, nonparalytic
Psittacosis 9 0.01 13 0.01 22
Q fever
Total 46 0.03 168 0.10 1 215
Acute 38 0.02 140 0.09 178
Chronic 8 0.00 28 0.02 1 37
Rabies
Human 1 0.00 2 0.00 3
Rubella 1 0.00 3 0.00 4
Rubella, congenital syndrome
Salmonellosis (excluding paratyphoid fever and typhoid fever) †† 32,510 19.58 28,215 17.51 274 60,999
Severe acute respiratory syndrome-associated coronavirus disease
Shiga toxin-producing Escherichia coli (STEC) 8,793 5.30 7,160 4.44 43 15,996
Shigellosis 6,690 4.03 9,587 5.95 56 16,333
Smallpox
Spotted fever rickettsiosis
Total 1,847 1.12 3,690 2.31 7 5,544
Confirmed 51 0.03 73 0.05 124
Probable 1,796 1.09 3,617 2.26 7 5,420
Streptococcal toxic shock syndrome 180 0.17 191 0.19 371
Syphilis
Total, all stages §§ 22,118 13.32 91,525 56.80 1,402 115,045
Congenital 1,306 1,306
Primary and secondary 4,995 3.01 30,034 18.64 34 35,063
Tetanus 11 0.01 12 0.01 23
Toxic shock syndrome (other than Streptococcal) 23 0.02 10 0.01 33
Trichinellosis 1 0.00 1
Tuberculosis 3,476 2.09 5,527 3.43 22 9,025
Tularemia 80 0.05 149 0.09 229
Typhoid fever 192 0.12 209 0.13 401
Vancomycin-intermediate Staphylococcus aureus 36 0.03 49 0.04 85
Vancomycin-resistant Staphylococcus aureus
Varicella morbidity 3,785 2.79 4,377 3.32 39 8,201
Varicella mortality U U U U U U
Vibriosis
Total 1,239 0.76 1,717 1.08 8 2,964
Confirmed 639 0.39 1,179 0.74 4 1,822
Probable 600 0.37 538 0.34 4 1,142
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus
Ebola virus
Guanarito virus
Junin virus
Lassa virus
Lujo virus
Machupo virus
Marburg virus
Sabia virus
Yellow fever
Zika virus
Zika virus disease, congenital ¶¶ 1 0.05 1 0.05 2
Zika virus disease, non-congenital 56 0.03 23 0.01 79
Zika virus infection, congenital ¶¶ 4 0.21 4 0.20 8
Zika virus infection, non-congenital 230 0.14 15 0.01 245
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • U: Unavailable — The data are unavailable.
  • * Reportable in <25 states.
  • † Counts include confirmed and probable dengue cases.
  • § Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/SurveillanceRpts.htm.
  • ¶ Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years.
  • ** Prior to 2018, cases of paratyphoid fever were considered salmonellosis.
  • †† Prior to 2018, cases of paratyphoid fever were included as salmonellosis, but beginning in 2018 they are being published as paratyphoid fever.
  • §§ Includes the following categories: primary; secondary; early non-primary non-secondary (includes cases previously reported as early latent); and unknown duration or late (includes cases previously reported as late latent syphilis and cases previously reported as late syphilis with clinical manifestations).
  • ¶¶ Data reported to ArboNET using the national surveillance case definition for congenital Zika virus infection (CSTE Position Statement 16-ID-01).

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