TABLE 5. Annual reported cases of notifiable diseases and rates per 100,000, by sex, excluding U.S. Territories - - United States, 2018 column labels in same order that data fields appears in each record below: Disease Female, No. Female, Rate Male, No. Male, Rate Sex not stated, No. Total, No. tab delimited data: Anthrax — — 1 0.00 — 1 Arboviral diseases, Chikungunya virus disease 79 0.05 38 0.02 — 117 Arboviral diseases, Eastern equine encephalitis virus disease, Neuroinvasive 3 0.00 3 0.00 — 6 Arboviral diseases, Eastern equine encephalitis virus disease, Non-neuroinvasive — — — — — — Arboviral diseases, Jamestown Canyon virus disease, Neuroinvasive 5 0.00 20 0.01 — 25 Arboviral diseases, Jamestown Canyon virus disease, Non-neuroinvasive 1 0.00 15 0.01 — 16 Arboviral diseases, La Crosse virus disease, Neuroinvasive 43 0.03 40 0.02 — 83 Arboviral diseases, La Crosse virus disease, Non-neuroinvasive — — 3 0.00 — 3 Arboviral diseases, Powassan virus disease, Neuroinvasive 7 0.00 14 0.01 — 21 Arboviral diseases, Powassan virus disease, Non-neuroinvasive — — — — — — Arboviral diseases, St. Louis encephalitis virus disease, Neuroinvasive 2 0.00 3 0.00 — 5 Arboviral diseases, St. Louis encephalitis virus disease, Non-neuroinvasive 2 0.00 1 0.00 — 3 Arboviral diseases, West Nile virus disease, Neuroinvasive 604 0.36 1,053 0.65 — 1,657 Arboviral diseases, West Nile virus disease, Non-neuroinvasive 405 0.24 584 0.36 — 989 Arboviral diseases, Western equine encephalitis virus disease, Neuroinvasive — — — — — — Arboviral diseases, Western equine encephalitis virus disease, Non-neuroinvasive — — — — — — Babesiosis, Total 765 0.55 1,393 1.04 2 2,160 Babesiosis, Confirmed 651 0.47 1,208 0.90 2 1,861 Babesiosis, Probable 114 0.08 185 0.14 — 299 Botulism, Total 112 0.07 113 0.07 — 225 Botulism, Foodborne 11 0.01 6 0.00 — 17 Botulism, Infant 86 4.58 71 3.61 — 157 Botulism, Other (wound & unspecified) 15 0.01 36 0.02 — 51 Brucellosis 56 0.03 82 0.05 — 138 Campylobacteriosis 33,351 20.09 36,693 22.77 156 70,200 Chancroid — — 3 0.00 — 3 Chlamydia trachomatis infection 1,145,063 689.64 610,447 378.86 3,158 1,758,668 Cholera 5 0.00 9 0.01 — 14 Coccidioidomycosis * 7,032 10.33 8,552 12.82 27 15,611 Cryptosporidiosis, Total 6,476 3.90 6,038 3.75 19 12,533 Cryptosporidiosis, Confirmed 4,540 2.73 4,428 2.75 12 8,980 Cryptosporidiosis, Probable 1,936 1.17 1,610 1.00 7 3,553 Cyclosporiasis 1,924 1.30 1,594 1.11 1 3,519 Dengue virus infections, Dengue † 215 0.13 209 0.13 — 424 Dengue virus infections, Dengue-like illness † 19 0.01 22 0.01 — 41 Dengue virus infections, Severe dengue † 8 0.00 1 0.00 — 9 Diphtheria 1 0.00 — — — 1 Ehrlichiosis and Anaplasmosis, Anaplasma phagocytophilum infection 1,575 0.98 2,430 1.57 3 4,008 Ehrlichiosis and Anaplasmosis, Ehrlichia chaffeensis infection 803 0.50 992 0.64 4 1,799 Ehrlichiosis and Anaplasmosis, Ehrlichia ewingii infection 10 0.01 23 0.01 — 33 Ehrlichiosis and Anaplasmosis, Undetermined ehrlichiosis/anaplasmosis 127 0.08 156 0.10 — 283 Giardiasis 5,957 4.58 9,540 7.55 51 15,548 Gonorrhea 241,074 145.19 341,401 211.88 930 583,405 Haemophilus influenzae, invasive disease, All ages, all serotypes 2,972 1.79 2,568 1.59 33 5,573 Haemophilus influenzae, invasive disease, Age <5 years, Serotype b 16 0.17 22 0.22 — 38 Haemophilus influenzae, invasive disease, Age <5 years, Non-b serotype 76 0.79 115 1.13 — 191 Haemophilus influenzae, invasive disease, Age <5 years, Nontypeable 97 1.00 123 1.21 2 222 Haemophilus influenzae, invasive disease, Age <5 years, Unknown serotype 72 0.74 102 1.01 1 175 Hansen's disease 30 0.02 43 0.03 17 90 Hantavirus infection, non-hantavirus pulmonary syndrome 1 0.00 1 0.00 — 2 Hantavirus pulmonary syndrome 10 0.01 8 0.01 — 18 Hemolytic uremic syndrome post-diarrheal 220 0.14 156 0.10 — 376 Hepatitis, A, acute § 4,951 2.98 7,497 4.65 26 12,474 Hepatitis, B, acute § 1,260 0.76 2,050 1.28 12 3,322 Hepatitis, B, perinatal infection § 15 0.40 8 0.20 — 23 Hepatitis, C, acute § 2,058 1.31 2,706 1.77 4 4,768 Hepatitis, C, acute, Confirmed § 1,605 1.02 2,012 1.32 4 3,621 Hepatitis, C, acute, Probable § 453 0.29 694 0.45 — 1,147 Hepatitis, C, perinatal infection § 117 0.08 97 0.07 — 214 Human immunodeficiency virus diagnoses 6,286 3.79 26,713 16.58 — 32,999 Influenza-associated pediatric mortality 90 0.25 69 0.18 — 159 Invasive pneumococcal disease, All ages ¶ 9,413 7.59 10,328 8.61 116 19,857 Invasive pneumococcal disease, All ages, Confirmed ¶ 9,291 7.49 10,212 8.52 116 19,619 Invasive pneumococcal disease, All ages, Probable ¶ 122 0.10 116 0.10 — 238 Invasive pneumococcal disease, Age <5 years ¶ 477 0.36 631 0.49 8 1,116 Invasive pneumococcal disease, Age <5 years, Confirmed ¶ 463 5.97 607 7.48 8 1,078 Invasive pneumococcal disease, Age <5 years, Probable ¶ 14 0.18 24 0.30 — 38 Legionellosis 3,637 2.19 6,289 3.90 7 9,933 Leptospirosis 21 0.02 70 0.05 — 91 Listeriosis 452 0.27 406 0.25 6 864 Lyme disease, Total 14,048 8.50 19,092 11.90 526 33,666 Lyme disease, Confirmed 9,708 5.87 13,346 8.32 504 23,558 Lyme disease, Probable 4,340 2.63 5,746 3.58 22 10,108 Malaria 659 0.40 1,085 0.67 4 1,748 Measles, Total 182 0.11 193 0.12 — 375 Measles, Indigenous 147 0.09 149 0.09 — 296 Measles, Imported 35 0.02 44 0.03 — 79 Meningococcal disease, All serogroups 161 0.10 166 0.10 — 327 Meningococcal disease, Serogroups ACWY 46 0.03 54 0.03 — 100 Meningococcal disease, Serogroup B 50 0.03 31 0.02 — 81 Meningococcal disease, Other serogroups 10 0.01 13 0.01 — 23 Meningococcal disease, Unknown serogroup 55 0.03 68 0.04 — 123 Mumps 1,032 0.62 1,477 0.92 6 2,515 Novel Influenza A virus infections 5 0.00 9 0.01 — 14 Paratyphoid fever ** 70 0.04 63 0.04 — 133 Pertussis 8,485 5.11 7,064 4.38 60 15,609 Plague — — 1 0.00 — 1 Poliomyelitis, paralytic — — — — — — Poliovirus infection, nonparalytic — — — — — — Psittacosis 9 0.01 13 0.01 — 22 Q fever, Total 46 0.03 168 0.10 1 215 Q fever, Acute 38 0.02 140 0.09 — 178 Q fever, Chronic 8 0.00 28 0.02 1 37 Rabies, Human 1 0.00 2 0.00 — 3 Rubella 1 0.00 3 0.00 — 4 Rubella, congenital syndrome — — — — — — Salmonellosis (excluding paratyphoid fever and typhoid fever) †† 32,510 19.58 28,215 17.51 274 60,999 Severe acute respiratory syndrome-associated coronavirus disease — — — — — — Shiga toxin-producing Escherichia coli (STEC) 8,793 5.30 7,160 4.44 43 15,996 Shigellosis 6,690 4.03 9,587 5.95 56 16,333 Smallpox — — — — — — Spotted fever rickettsiosis, Total 1,847 1.12 3,690 2.31 7 5,544 Spotted fever rickettsiosis, Confirmed 51 0.03 73 0.05 — 124 Spotted fever rickettsiosis, Probable 1,796 1.09 3,617 2.26 7 5,420 Streptococcal toxic shock syndrome 180 0.17 191 0.19 — 371 Syphilis, Total, all stages §§ 22,118 13.32 91,525 56.80 1,402 115,045 Syphilis, Congenital — — — — 1,306 1,306 Syphilis, Primary and secondary 4,995 3.01 30,034 18.64 34 35,063 Tetanus 11 0.01 12 0.01 — 23 Toxic shock syndrome (other than Streptococcal) 23 0.02 10 0.01 — 33 Trichinellosis 1 0.00 — — — 1 Tuberculosis 3,476 2.09 5,527 3.43 22 9,025 Tularemia 80 0.05 149 0.09 — 229 Typhoid fever 192 0.12 209 0.13 — 401 Vancomycin-intermediate Staphylococcus aureus 36 0.03 49 0.04 — 85 Vancomycin-resistant Staphylococcus aureus — — — — — — Varicella morbidity 3,785 2.79 4,377 3.32 39 8,201 Varicella mortality U U U U U U Vibriosis, Total 1,239 0.76 1,717 1.08 8 2,964 Vibriosis, Confirmed 639 0.39 1,179 0.74 4 1,822 Vibriosis, Probable 600 0.37 538 0.34 4 1,142 Viral hemorrhagic fevers, Crimean-Congo hemorrhagic fever virus — — — — — — Viral hemorrhagic fevers, Ebola virus — — — — — — Viral hemorrhagic fevers, Guanarito virus — — — — — — Viral hemorrhagic fevers, Junin virus — — — — — — Viral hemorrhagic fevers, Lassa virus — — — — — — Viral hemorrhagic fevers, Lujo virus — — — — — — Viral hemorrhagic fevers, Machupo virus — — — — — — Viral hemorrhagic fevers, Marburg virus — — — — — — Viral hemorrhagic fevers, Sabia virus — — — — — — Yellow fever — — — — — — Zika virus, Zika virus disease, congenital ¶¶ 1 0.05 1 0.05 — 2 Zika virus, Zika virus disease, non-congenital 56 0.03 23 0.01 — 79 Zika virus, Zika virus infection, congenital ¶¶ 4 0.21 4 0.20 — 8 Zika virus, Zika virus infection, non-congenital 230 0.14 15 0.01 — 245 —: No reported cases - The reporting jurisdiction did not submit any cases to CDC. U: Unavailable - The data are unavailable. * Reportable in <25 states. † Counts include confirmed and probable dengue cases. § Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/SurveillanceRpts.htm. ¶ Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years. ** Prior to 2018, cases of paratyphoid fever were considered salmonellosis. †† Prior to 2018, cases of paratyphoid fever were included as salmonellosis, but beginning in 2018 they are being published as paratyphoid fever. §§ Includes the following categories: primary; secondary; early non-primary non-secondary (includes cases previously reported as early latent); and unknown duration or late (includes cases previously reported as late latent syphilis and cases previously reported as late syphilis with clinical manifestations). ¶¶ Data reported to ArboNET using the national surveillance case definition for congenital Zika virus infection (CSTE Position Statement 16-ID-01). Notes: These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables. The list of nationally notifiable infectious diseases and conditions for 2018 and their national surveillance case definitions are available by navigating to the https://ndc.services.cdc.gov/, Surveillance Case Definitions | CDC web page, selecting "2018" for the notifiable condition list year, checking "infectious" conditions, and clicking "Get Notifiable List by Year". This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved in 2017 by CSTE for national surveillance, that were implemented in January 2018, including updated surveillance case definitions for anthrax, shiga toxin-producing Escherichia coli, and syphilis. Perinatal hepatitis c virus infection became a new nationally notifiable condition in 2018. While Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae (CP-CRE) was added to the list of nationally notifiable diseases in 2018, reporting jurisdictions could not submit data for this condition since Office of Management and Budget Paperwork Reduction Act approval was pending during 2018. Publication criteria for the finalized 2018 data are available at https://wonder.cdc.gov/nndss/documents/2018_NNDSS _Publication_Criteria_07122019_updated_09230219.pdf, https://wonder.cdc.gov/nndss/documents/2018_NNDSS _Publication_Criteria_07122019_updated_09230219.pdf. See also https://ndc.services.cdc.gov/wp-content/uploads/Users_guide_WONDER_tables_cleared_final.pdf, Guide to Interpreting Provisional and Finalized NNDSS Data. Annual tables for 2016 and later years are available on https://wonder.cdc.gov/nndss/nndss_annual_tables_menu.asp, CDC WONDER. Annual summary reports from 1993-2015 are available as published in the https://www.cdc.gov/mmwr/mmwr_nd/index.html, MMWR. NNDSS annual tables since 1952 are available at https://stacks.cdc.gov/nndss, CDC Stacks (once in CDC Stacks select "Annual Reports" in the "Genre" box to the left). For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a nationally notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations. Population estimates for incidence rates are July 1st, 2018 estimates obtained from the National Center for Health Statistics (NCHS) postcensal estimates of the resident population of the United States for April 1, 2010 - July 1, 2018, by year, county, single year of age (range: 0 to 85 years), bridged-race (white, black or African American, American Indian or Alaska Native, Asian, or Pacific Islander), Hispanic ethnicity (not Hispanic or Latino, Hispanic or Latino), and sex (Vintage 2018), prepared under a collaborative arrangement with the U.S. Census Bureau. Population estimates for states released June 25, 2019 are available at https://www.cdc.gov/nchs/nvss/bridged_race/data_documentation.htm, https://www.cdc.gov/nchs/nvss/bridged_race/data_documentation.htm. Population estimates for territories are the 2018 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on June 26, 2019 at https://www.census.gov/data-tools/demo/idb/informationGateway.php, https://www.census.gov/data-tools/demo/idb/informationGateway.php. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation. Age restrictions in the numerator and denominator are applied for the following childhood conditions: Zika virus disease, congenital (age restriction in numerator and denominator is <1 year) Zika virus infection, congenital (age restriction in numerator and denominator is <1 year) Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years) Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years) Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years) Infant botulism (age restriction in numerator and denominator is <1 year) Congenital rubella syndrome (age restriction in numerator and denominator is <1 year) Perinatal Hepatitis B infection (age restriction in numerator is ≤24 months, denominator is <24 months) Perinatal Hepatitis C infection (age restriction in numerator is ≤36 months, denominator is <36 months) Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2018 (National Center for Health Statistics https://wonder.cdc.gov/natality.html, Natality 2018, as compiled from data provided by the Vital Statistics Cooperative Program). The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases. Congenital syphilis data are published in Syphilis Statistics in the Sexually Transmitted Diseases (STD) surveillance report (https://www.cdc.gov/std/syphilis/stats.htm, https://www.cdc.gov/std/syphilis/stats.htm) and in the historical archives of the STD surveillance report (https://www.cdc.gov/std/stats/archive.htm, https://www.cdc.gov/std/stats/archive.htm). The STD surveillance report (https://www.cdc.gov/std/syphilis/stats.htm, https://www.cdc.gov/std/syphilis/stats.htm) updates congenital syphilis cases and rates over time. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC). Suggested Citation: Centers for Disease Control and Prevention. National Notifiable Diseases Surveillance System, 2018 Annual Tables of Infectious Disease Data. Atlanta, GA. CDC Division of Health Informatics and Surveillance, 2019. Available at: https://www.cdc.gov/nndss/data-statistics/infectious-tables/index.html, https://www.cdc.gov/nndss/data-statistics/infectious-tables/index.html. Acknowledgement: CDC acknowledges the Local, State, and Territorial Health Departments that collected the data from a range of case ascertainment sources (e.g., health-care providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System. https://www.cdc.gov/nndss/, National Notifiable Diseases Surveillance System Provided by https://wonder.cdc.gov, CDC WONDER