Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 4. Annual reported cases of notifiable diseases and rates, by age group, United States, excluding U.S. Territories and Non-U.S. Residents, 2019
Data from some jurisdictions may be incomplete due to the coronavirus disease 2019 (COVID-19) pandemic. Please see Note #9 at the bottom of the table.
Disease <1 yr 1-4 yrs 5-14 yrs 15-24 yrs 25-39 yrs 40-64 yrs ≥65 yrs Age not stated Total
No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. No.
Anthrax 1 0.00 1
Arboviral diseases
Chikungunya virus disease 1 0.03 2 0.01 7 0.02 24 0.06 50 0.07 90 0.09 18 0.03 192
Eastern equine encephalitis virus disease
Neuroinvasive 4 0.01 2 0.00 15 0.01 17 0.03 38
Non-neuroinvasive
Jamestown Canyon virus disease
Neuroinvasive 1 0.03 1 0.00 2 0.00 6 0.01 3 0.00 12 0.02 25
Non-neuroinvasive 8 0.01 8 0.01 4 0.01 20
La Crosse virus disease
Neuroinvasive 1 0.03 9 0.06 33 0.08 1 0.00 1 0.00 3 0.01 48
Non-neuroinvasive 1 0.03 2 0.01 4 0.01 7
Powassan virus disease
Neuroinvasive 1 0.03 4 0.01 4 0.01 12 0.01 18 0.03 39
Non-neuroinvasive 1 0.00 1 0.00 2 0.00 4
St. Louis encephalitis virus disease
Neuroinvasive 1 0.00 5 0.00 9 0.02 15
Non-neuroinvasive 1 0.00 1 0.00 2
West Nile virus disease
Neuroinvasive 14 0.03 15 0.04 69 0.10 259 0.25 279 0.52 636
Non-neuroinvasive 5 0.01 18 0.04 49 0.07 170 0.16 96 0.18 338
Western equine encephalitis virus disease
Neuroinvasive
Non-neuroinvasive
Babesiosis
Total 1 0.03 14 0.11 48 0.14 54 0.15 147 0.26 961 1.13 1,194 2.69 1 2,420
Confirmed 1 0.03 11 0.08 35 0.10 37 0.11 111 0.20 808 0.95 1,062 2.39 1 2,066
Probable 3 0.02 13 0.04 17 0.05 36 0.06 153 0.18 132 0.30 354
Botulism
Total 147 3.89 1 0.01 13 0.02 27 0.03 7 0.01 1 196
Foodborne 1 0.03 2 0.00 11 0.01 6 0.01 20
Infant 146 3.86 1 1 148
Other (wound & unspecified) 11 0.02 16 0.02 1 0.00 28
Brucellosis 1 0.01 3 0.01 9 0.02 44 0.07 69 0.07 39 0.07 165
Campylobacteriosis 1,844 48.74 5,957 37.72 4,986 12.16 7,460 17.48 13,200 19.50 23,477 22.74 14,452 26.73 133 71,509
Candida auris, clinical * 2 0.01 11 0.02 81 0.09 80 0.16 1 175
Carbapenemase-producing carbapenem-resistant Enterobacteriaceae 5 0.14 4 0.03 7 0.02 23 0.06 93 0.15 581 0.61 769 1.58 1 1,483
Chancroid 4 0.01 3 0.00 1 0.00 8
Chlamydia trachomatis infection 425 11.23 98 0.62 11,743 28.65 1,103,377 2,584.78 588,900 870.15 97,469 94.41 2,783 5.15 3,908 1,808,703
Cholera 1 0.01 3 0.00 7 0.01 3 0.01 14
Coccidioidomycosis  10 0.63 50 0.75 480 2.77 1,371 7.63 3,378 11.93 7,586 17.72 5,521 24.65 11 18,407
Cryptosporidiosis
Total 153 4.04 1,507 9.54 1,564 3.82 1,946 4.56 3,476 5.14 3,441 3.33 1,862 3.44 26 13,975
Confirmed 118 3.12 1,197 7.58 1,163 2.84 1,503 3.52 2,679 3.96 2,424 2.35 1,085 2.01 16 10,185
Probable 35 0.93 310 1.96 401 0.98 443 1.04 797 1.18 1,017 0.99 777 1.44 10 3,790
Cyclosporiasis 4 0.12 17 0.12 36 0.10 265 0.68 1,071 1.73 2,323 2.47 921 1.88 66 4,703
Dengue virus infections §
Dengue 1 0.03 15 0.09 123 0.30 182 0.43 326 0.48 577 0.56 190 0.35 1,414
Dengue-like illness 4 0.01 4 0.01 8 0.01 23 0.02 4 0.01 43
Severe dengue 2 0.00 1 0.00 10 0.01 14 0.01 3 0.01 30
Diphtheria 1 0.00 1 0.00 2
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection 2 0.05 12 0.08 106 0.27 139 0.34 454 0.70 2,402 2.41 2,536 4.86 4 5,655
Ehrlichia chaffeensis infection 1 0.03 7 0.05 65 0.16 128 0.31 235 0.36 873 0.88 772 1.48 12 2,093
Ehrlichia ewingii infection 4 0.01 5 0.01 23 0.02 11 0.02 43
Undetermined ehrlichiosis/anaplasmosis 1 0.01 7 0.02 12 0.03 25 0.04 85 0.09 53 0.10 2 185
Giardiasis 103 3.53 1,177 9.68 1,330 4.21 1,569 4.74 3,395 6.42 5,147 6.34 2,116 4.88 23 14,860
Gonorrhea 107 2.83 111 0.70 2,752 6.71 255,677 598.95 277,288 409.72 77,308 74.88 2,703 5.00 446 616,392
Haemophilus influenzae, invasive disease
All ages, all serotypes 407 10.76 278 1.76 140 0.34 155 0.36 407 0.60 1,525 1.48 3,231 5.98 6,143
Age <5 years
Serotype b 11 0.29 7 0.04 18
Non-b serotype 98 2.59 115 0.73 213
Nontypeable 135 3.57 65 0.41 200
Unknown serotype 163 4.31 91 0.58 254
Hansen's disease 2 0.01 6 0.02 15 0.02 29 0.03 24 0.05 1 77
Hantavirus infection, non-hantavirus pulmonary syndrome  1 0.00 2 0.00 3
Hantavirus pulmonary syndrome 4 0.01 6 0.01 7 0.01 1 0.00 18
Hemolytic uremic syndrome post-diarrheal 7 0.19 156 1.01 104 0.26 29 0.07 27 0.04 32 0.03 36 0.07 1 392
Hepatitis **
A, acute 4 0.11 37 0.23 133 0.32 1,190 2.79 8,976 13.26 7,518 7.28 985 1.82 3 18,846
B, acute 1 0.01 1 0.00 96 0.23 1,025 1.52 2,133 2.08 287 0.53 1 3,544
B, perinatal infection 12 0.32 6 0.16 1 19
C, acute 3 0.02 3 0.01 602 1.47 2,936 4.53 1,714 1.73 215 0.42 6 5,479
Confirmed 3 0.02 2 0.01 499 1.22 2,165 3.34 1,274 1.29 190 0.37 3 4,136
Probable 1 0.00 103 0.25 771 1.19 440 0.44 25 0.05 3 1,343
C, perinatal infection 80 2.36 137 1.98 217
Human immunodeficiency virus diagnoses 22 0.58 12 0.08 38 0.09 6,447 15.10 14,979 22.13 9,461 9.16 764 1.41 31,723
Influenza-associated pediatric mortality 24 0.63 56 0.35 69 0.17 11 0.09 160
Invasive pneumococcal disease ††
All ages 358 12.70 694 5.90 470 1.54 325 1.02 1,704 3.42 8,209 10.63 8,177 19.96 14 19,951
Confirmed 348 12.35 681 5.79 447 1.47 317 1.00 1,683 3.38 8,113 10.51 8,086 19.74 14 19,689
Probable 10 0.35 13 0.11 23 0.08 8 0.03 21 0.04 96 0.12 91 0.22 262
Age <5 years 380 12.53 735 5.80 1,115
Confirmed 369 12.17 722 5.70 1,091
Probable 11 0.36 13 0.10 24
Legionellosis 6 0.16 1 0.01 4 0.01 77 0.18 579 0.86 4,209 4.08 3,995 7.39 19 8,890
Leptospirosis 2 0.01 10 0.03 23 0.04 49 0.06 10 0.02 94
Listeriosis §§
Total 65 1.72 4 0.03 6 0.01 21 0.05 98 0.14 201 0.19 531 0.98 2 928
Confirmed 57 1.51 4 0.03 6 0.01 19 0.04 79 0.12 194 0.19 520 0.96 1 880
Probable 8 0.21 2 0.00 19 0.03 7 0.01 11 0.02 1 48
Lyme disease
Total 13 0.35 1,055 6.71 4,785 11.72 2,914 6.85 4,689 6.96 12,388 12.05 9,088 16.90 13 34,945
Confirmed 12 0.32 869 5.53 3,563 8.73 1,792 4.21 3,015 4.47 8,401 8.17 5,790 10.76 11 23,453
Probable 1 0.03 186 1.18 1,222 2.99 1,122 2.64 1,674 2.48 3,987 3.88 3,298 6.13 2 11,492
Malaria 4 0.11 46 0.29 205 0.50 237 0.56 524 0.77 755 0.73 162 0.30 3 1,936
Measles ¶¶
Total 154 4.07 398 2.52 318 0.78 124 0.29 152 0.22 122 0.12 5 0.01 2 1,275
Indigenous 147 3.89 389 2.46 303 0.74 113 0.26 131 0.19 104 0.10 3 0.01 2 1,192
Imported 7 0.19 9 0.06 15 0.04 11 0.03 21 0.03 18 0.02 2 0.00 83
Meningococcal disease
All serogroups 27 0.71 34 0.22 14 0.03 52 0.12 58 0.09 96 0.09 90 0.17 371
Serogroups ACWY 3 0.08 11 0.07 9 0.02 7 0.02 19 0.03 46 0.04 44 0.08 139
Serogroup B 9 0.24 7 0.04 1 0.00 11 0.03 11 0.02 10 0.01 11 0.02 60
Other serogroups 2 0.05 2 0.01 10 0.02 2 0.00 4 0.00 4 0.01 24
Unknown serogroup 13 0.34 14 0.09 4 0.01 24 0.06 26 0.04 36 0.03 31 0.06 148
Mumps 16 0.42 137 0.87 284 0.69 1,523 3.57 1,131 1.67 575 0.56 106 0.20 8 3,780
Novel Influenza A virus infections 1 0.00 1
Pertussis 2,183 57.70 2,876 18.21 5,874 14.33 3,717 8.71 1,053 1.56 2,030 1.97 864 1.60 20 18,617
Plague 1 0.00 1
Poliomyelitis, paralytic
Poliovirus infection, nonparalytic
Psittacosis 1 0.00 2 0.00 1 0.00 4
Q fever
Total 3 0.01 7 0.02 24 0.04 101 0.10 76 0.14 1 212
Acute 3 0.01 7 0.02 21 0.03 90 0.09 56 0.10 1 178
Chronic 3 0.00 11 0.01 20 0.04 34
Rabies
Human
Rubella 1 0.01 2 0.00 2 0.00 1 0.00 6
Rubella, congenital syndrome 1 1
Salmonella Paratyphi infection *** 2 0.05 14 0.09 32 0.08 26 0.06 40 0.06 34 0.03 7 0.01 155
Salmonella Typhi infection ††† 7 0.19 43 0.27 79 0.19 79 0.19 121 0.18 63 0.06 16 0.03 1 409
Salmonellosis (excluding S. Typhi infection and S. Paratyphi infection) §§§ 5,629 148.80 7,783 49.28 5,313 12.96 4,988 11.68 8,269 12.22 15,356 14.87 10,904 20.17 129 58,371
Severe acute respiratory syndrome-associated coronavirus disease
Shiga toxin-producing Escherichia coli (STEC) 611 16.15 2,916 18.46 1,895 4.62 2,481 5.81 2,781 4.11 3,521 3.41 2,702 5.00 32 16,939
Shigellosis 270 7.14 3,354 21.24 3,058 7.46 1,603 3.76 4,182 6.18 4,515 4.37 1,560 2.89 32 18,574
Smallpox
Spotted fever rickettsiosis
Total 1 0.03 31 0.20 172 0.42 404 0.95 949 1.41 2,392 2.33 1,246 2.32 12 5,207
Confirmed 1 0.03 4 0.03 9 0.02 8 0.02 15 0.02 54 0.05 37 0.07 128
Probable 27 0.17 163 0.40 396 0.93 934 1.39 2,338 2.28 1,209 2.25 12 5,079
Streptococcal toxic shock syndrome 12 0.12 16 0.06 9 0.03 51 0.12 166 0.25 162 0.46 416
Syphilis
Total, all stages ¶¶¶ 1,875 49.56 11 0.07 72 0.18 23,266 54.50 65,883 97.35 36,207 35.07 2,467 4.56 32 129,813
Congenital 1,870 49.90 1,870
Primary and secondary 2 0.05 3 0.02 24 0.06 8,033 18.82 19,974 29.51 10,437 10.11 515 0.95 4 38,992
Tetanus 2 0.01 2 0.00 2 0.00 5 0.01 8 0.01 7 0.01 26
Toxic shock syndrome (other than Streptococcal) 4 0.04 9 0.03 16 0.05 6 0.01 4 0.01 5 0.01 44
Trichinellosis 3 0.00 4 0.00 7
Tuberculosis 58 1.53 157 0.99 152 0.37 850 1.99 2,053 3.03 3,224 3.12 2,422 4.48 8,916
Tularemia 1 0.03 18 0.11 29 0.07 32 0.07 44 0.07 90 0.09 58 0.11 2 274
Vancomycin-intermediate Staphylococcus aureus 1 0.00 1 0.00 8 0.02 37 0.05 29 0.07 76
Vancomycin-resistant Staphylococcus aureus 3 0.00 3
Varicella morbidity 836 26.91 1,623 12.53 2,644 7.87 955 2.73 1,016 1.83 655 0.78 76 0.17 492 8,297
Varicella mortality U U U U U U U U U U U U U U U U
Vibriosis
Total 28 0.75 74 0.48 158 0.39 195 0.46 539 0.81 1,122 1.10 733 1.38 2 2,851
Confirmed 4 0.11 24 0.15 115 0.29 113 0.27 325 0.49 682 0.67 387 0.73 1 1,651
Probable 24 0.64 50 0.32 43 0.11 82 0.20 214 0.32 440 0.43 346 0.65 1 1,200
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus
Ebola virus
Guanarito virus
Junin virus
Lassa virus
Lujo virus
Machupo virus
Marburg virus
Sabia virus
Yellow fever
Zika virus
Zika virus disease, congenital ****
Zika virus disease, non-congenital 1 0.00 6 0.01 10 0.01 11 0.01 28
Zika virus infection, congenital ****
Zika virus infection, non-congenital 2 0.00 67 0.16 98 0.14 9 0.01 1 0.00 177
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • U: Unavailable — The data are unavailable.
  • * Candida auris colonization/screening cases are not included in this table. These data are available on the Mycotic Diseases Branch's Tracking Candida auris page (https://www.cdc.gov/fungal/candida-auris/tracking-c-auris.html)
  • † Reportable in <25 states.
  • § Counts include confirmed and probable dengue cases.
  • ¶ Includes data for old world hantavirus infections, such as Seoul virus and Puumala virus infections.
  • ** Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/SurveillanceRpts.htm.
  • †† Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years.
  • §§ Before 2019, probable cases were not reported, and cases in neonates ≤60 days of age were counted as one case in a mother-infant pair. Beginning in 2019, confirmed and probable cases are being reported, and maternal and neonatal cases are being counted separately
  • ¶¶ Measles is considered imported if the disease was acquired outside of the United States and is considered indigenous if the disease was acquired anywhere within the United States or it is not known where the disease was acquired.
  • *** Beginning in January 2019, cases began to be reported as Salmonella Paratyphi infection. In 2018, cases were reported as paratyphoid fever. Prior to 2018, cases of paratyphoid fever were considered salmonellosis.
  • ††† Beginning in January 2019, cases began to be reported as Salmonella Typhi infection. In previous years, cases were reported as typhoid fever.
  • §§§ Beginning in January 2019, cases began to be reported as salmonellosis (excluding Salmonella Typhi infection and Salmonella Paratyphi infection). In 2018, cases were reported as salmonellosis (excluding paratyphoid fever and typhoid fever). Prior to 2018, cases of paratyphoid fever were considered salmonellosis.
  • ¶¶¶ Includes the following categories: primary; secondary; early non-primary non-secondary (includes cases previously reported as early latent); and unknown duration or late (includes cases previously reported as late latent syphilis and cases previously reported as late syphilis with clinical manifestations).
  • **** Data reported to ArboNET using the national surveillance case definition for congenital Zika virus infection (CSTE Position Statement 16-ID-01).