Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 5. Annual reported cases of notifiable diseases and rates, by sex, United States, excluding U.S. Territories and Non-U.S. Residents, 2019
Data from some jurisdictions may be incomplete due to the coronavirus disease 2019 (COVID-19) pandemic. Please see Note #9 at the bottom of the table.
Disease Female Male Sex not stated Total
No. Rate No. Rate No. No.
Anthrax — — 1 0.00 — 1
Arboviral diseases
Chikungunya virus disease 101 0.06 91 0.06 — 192
Eastern equine encephalitis virus disease
Neuroinvasive 11 0.01 27 0.02 — 38
Non-neuroinvasive — — — — — —
Jamestown Canyon virus disease
Neuroinvasive 7 0.00 18 0.01 — 25
Non-neuroinvasive 8 0.00 12 0.01 — 20
La Crosse virus disease
Neuroinvasive 17 0.01 31 0.02 — 48
Non-neuroinvasive 5 0.00 2 0.00 — 7
Powassan virus disease
Neuroinvasive 11 0.01 28 0.02 — 39
Non-neuroinvasive 1 0.00 3 0.00 — 4
St. Louis encephalitis virus disease
Neuroinvasive 5 0.00 10 0.01 — 15
Non-neuroinvasive — — 2 0.00 — 2
West Nile virus disease
Neuroinvasive 242 0.15 394 0.24 — 636
Non-neuroinvasive 158 0.09 180 0.11 — 338
Western equine encephalitis virus disease
Neuroinvasive — — — — — —
Non-neuroinvasive — — — — — —
Babesiosis
Total 819 0.60 1,575 1.19 26 2,420
Confirmed 674 0.49 1,371 1.03 21 2,066
Probable 145 0.11 204 0.15 5 354
Botulism
Total 74 0.04 122 0.08 — 196
Foodborne 9 0.01 11 0.01 — 20
Infant 62 3.36 86 4.44 — 148
Other (wound & unspecified) 3 0.00 25 0.02 — 28
Brucellosis 63 0.04 101 0.06 1 165
Campylobacteriosis 33,346 20.02 37,750 23.35 413 71,509
Candida auris, clinical * 54 0.04 86 0.06 35 175
Carbapenemase-producing carbapenem-resistant Enterobacteriaceae 694 0.45 714 0.48 75 1,483
Chancroid 2 0.00 6 0.00 — 8
Chlamydia trachomatis infection 1,160,470 696.64 644,337 398.58 3,896 1,808,703
Cholera 6 0.00 7 0.00 1 14
Coccidioidomycosis † 8,918 12.86 9,455 13.95 34 18,407
Cryptosporidiosis
Total 7,087 4.25 6,772 4.19 116 13,975
Confirmed 5,063 3.04 5,045 3.12 77 10,185
Probable 2,024 1.22 1,727 1.07 39 3,790
Cyclosporiasis 2,708 1.79 1,983 1.35 12 4,703
Dengue virus infections §
Dengue 719 0.43 694 0.43 1 1,414
Dengue-like illness 20 0.01 23 0.01 — 43
Severe dengue 13 0.01 16 0.01 1 30
Diphtheria 1 0.00 1 0.00 — 2
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection 2,206 1.37 3,410 2.19 39 5,655
Ehrlichia chaffeensis infection 775 0.48 1,291 0.83 27 2,093
Ehrlichia ewingii infection 7 0.00 35 0.02 1 43
Undetermined ehrlichiosis/anaplasmosis 81 0.05 102 0.07 2 185
Giardiasis 5,507 4.22 9,293 7.34 60 14,860
Gonorrhea 253,359 152.09 361,586 223.67 1,447 616,392
Haemophilus influenzae, invasive disease
All ages, all serotypes 3,297 1.98 2,787 1.72 59 6,143
Age <5 years
Serotype b 8 0.08 10 0.10 — 18
Non-b serotype 85 0.89 127 1.27 1 213
Nontypeable 79 0.83 121 1.21 — 200
Unknown serotype 113 1.18 135 1.35 6 254
Hansen's disease 22 0.01 55 0.04 — 77
Hantavirus infection, non-hantavirus pulmonary syndrome  2 0.00 1 0.00 — 3
Hantavirus pulmonary syndrome 9 0.01 9 0.01 — 18
Hemolytic uremic syndrome post-diarrheal 220 0.14 171 0.11 1 392
Hepatitis **
A, acute 6,997 4.20 11,824 7.31 25 18,846
B, acute 1,296 0.78 2,245 1.40 3 3,544
B, perinatal infection 7 0.19 12 0.31 — 19
C, acute 2,131 1.34 3,336 2.15 12 5,479
Confirmed 1,653 1.04 2,471 1.60 12 4,136
Probable 478 0.30 865 0.56 — 1,343
C, perinatal infection 122 2.42 93 1.76 2 217
Human immunodeficiency virus diagnoses 6,068 3.64 25,655 15.87 — 31,723
Influenza-associated pediatric mortality 84 0.24 74 0.20 2 160
Invasive pneumococcal disease ††
All ages 9,326 7.49 10,517 8.74 108 19,951
Confirmed 9,210 7.40 10,373 8.62 106 19,689
Probable 116 0.09 144 0.12 2 262
Age <5 years 465 0.35 644 0.50 6 1,115
Confirmed 457 5.95 628 7.82 6 1,091
Probable 8 0.10 16 0.20 — 24
Legionellosis 3,256 1.95 5,574 3.45 60 8,890
Leptospirosis 13 0.01 81 0.06 — 94
Listeriosis §§
Total 481 0.29 444 0.27 3 928
Confirmed 447 0.27 431 0.27 2 880
Probable 34 0.02 13 0.01 1 48
Lyme disease
Total 14,578 8.79 19,612 12.19 755 34,945
Confirmed 9,590 5.78 13,164 8.18 699 23,453
Probable 4,988 3.01 6,448 4.01 56 11,492
Malaria 679 0.41 1,217 0.75 40 1,936
Measles ¶¶
Total 538 0.32 737 0.46 — 1,275
Indigenous 501 0.30 691 0.43 — 1,192
Imported 37 0.02 46 0.03 — 83
Meningococcal disease
All serogroups 184 0.11 187 0.12 — 371
Serogroups ACWY 65 0.04 74 0.05 — 139
Serogroup B 30 0.02 30 0.02 — 60
Other serogroups 16 0.01 8 0.00 — 24
Unknown serogroup 73 0.04 75 0.05 — 148
Mumps 1,299 0.78 2,458 1.52 23 3,780
Novel Influenza A virus infections — — 1 0.00 — 1
Pertussis 10,197 6.12 8,368 5.18 52 18,617
Plague — — 1 0.00 — 1
Poliomyelitis, paralytic — — — — — —
Poliovirus infection, nonparalytic — — — — — —
Psittacosis 3 0.00 1 0.00 — 4
Q fever
Total 44 0.03 164 0.10 4 212
Acute 38 0.02 137 0.09 3 178
Chronic 6 0.00 27 0.02 1 34
Rabies
Human — — — — — —
Rubella 3 0.00 3 0.00 — 6
Rubella, congenital syndrome — — 1 0.05 — 1
Salmonella Paratyphi infection *** 68 0.04 86 0.05 1 155
Salmonella Typhi infection ††† 191 0.11 218 0.13 — 409
Salmonellosis (excluding S. Typhi infection and S. Paratyphi infection) §§§ 30,396 18.25 27,355 16.92 620 58,371
Severe acute respiratory syndrome-associated coronavirus disease — — — — — —
Shiga toxin-producing Escherichia coli (STEC) 9,400 5.64 7,429 4.60 110 16,939
Shigellosis 7,611 4.57 10,798 6.68 165 18,574
Smallpox — — — — — —
Spotted fever rickettsiosis
Total 1,683 1.02 3,441 2.14 83 5,207
Confirmed 40 0.02 85 0.05 3 128
Probable 1,643 0.99 3,356 2.09 80 5,079
Streptococcal toxic shock syndrome 187 0.17 227 0.22 2 416
Syphilis
Total, all stages ¶¶¶ 28,172 16.91 99,240 61.39 2,401 129,813
Congenital — — — — 1,870 1,870
Primary and secondary 6,493 3.90 32,402 20.04 97 38,992
Tetanus 10 0.01 16 0.01 — 26
Toxic shock syndrome (other than Streptococcal) 28 0.02 16 0.01 — 44
Trichinellosis 2 0.00 5 0.00 — 7
Tuberculosis 3,555 2.13 5,361 3.32 — 8,916
Tularemia 96 0.06 175 0.11 3 274
Vancomycin-intermediate Staphylococcus aureus 33 0.03 42 0.03 1 76
Vancomycin-resistant Staphylococcus aureus 1 0.00 2 0.00 — 3
Varicella morbidity 3,456 2.54 4,377 3.31 464 8,297
Varicella mortality U U U U U U
Vibriosis
Total 1,117 0.68 1,711 1.07 23 2,851
Confirmed 511 0.31 1,123 0.71 17 1,651
Probable 606 0.37 588 0.37 6 1,200
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus — — — — — —
Ebola virus — — — — — —
Guanarito virus — — — — — —
Junin virus — — — — — —
Lassa virus — — — — — —
Lujo virus — — — — — —
Machupo virus — — — — — —
Marburg virus — — — — — —
Sabia virus — — — — — —
Yellow fever — — — — — —
Zika virus
Zika virus disease, congenital **** — — — — — —
Zika virus disease, non-congenital 20 0.01 8 0.00 — 28
Zika virus infection, congenital **** — — — — — —
Zika virus infection, non-congenital 168 0.10 9 0.01 — 177
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • U: Unavailable — The data are unavailable.
  • * Candida auris colonization/screening cases are not included in this table. These data are available on the Mycotic Diseases Branch's Tracking Candida auris page (https://www.cdc.gov/fungal/candida-auris/tracking-c-auris.html)
  • † Reportable in <25 states.
  • § Counts include confirmed and probable dengue cases.
  • ¶ Includes data for old world hantavirus infections, such as Seoul virus and Puumala virus infections.
  • ** Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/SurveillanceRpts.htm.
  • †† Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years.
  • §§ Before 2019, probable cases were not reported, and cases in neonates ≤60 days of age were counted as one case in a mother-infant pair. Beginning in 2019, confirmed and probable cases are being reported, and maternal and neonatal cases are being counted separately
  • ¶¶ Measles is considered imported if the disease was acquired outside of the United States and is considered indigenous if the disease was acquired anywhere within the United States or it is not known where the disease was acquired.
  • *** Beginning in January 2019, cases began to be reported as Salmonella Paratyphi infection. In 2018, cases were reported as paratyphoid fever. Prior to 2018, cases of paratyphoid fever were considered salmonellosis.
  • ††† Beginning in January 2019, cases began to be reported as Salmonella Typhi infection. In previous years, cases were reported as typhoid fever.
  • §§§ Beginning in January 2019, cases began to be reported as salmonellosis (excluding Salmonella Typhi infection and Salmonella Paratyphi infection). In 2018, cases were reported as salmonellosis (excluding paratyphoid fever and typhoid fever). Prior to 2018, cases of paratyphoid fever were considered salmonellosis.
  • ¶¶¶ Includes the following categories: primary; secondary; early non-primary non-secondary (includes cases previously reported as early latent); and unknown duration or late (includes cases previously reported as late latent syphilis and cases previously reported as late syphilis with clinical manifestations).
  • **** Data reported to ArboNET using the national surveillance case definition for congenital Zika virus infection (CSTE Position Statement 16-ID-01).
Notes:
  1. These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables.
  2. The list of national notifiable infectious diseases and conditions for 2019 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2019" for the notifiable condition list year, checking "infectious" conditions, and clicking "Get Notifiable List by Year". This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved in 2018 by CSTE for national surveillance that were implemented in January 2019. Candida auris, clinical became a new national notifiable condition, and revised case definitions were implemented for the following conditions: diphtheria, acute hepatitis A, listeriosis, yellow fever, Salmonella Paratyphi infection and Salmonella Typhi infection. Salmonella Paratyphi infection and Salmonella Typhi infection replaced Paratyphoid fever and Typhoid fever, respectively, as national notifiable conditions. Salmonellosis (excluding S. Typhi infection and S. Paratyphi infection) replaced Salmonellosis (excluding paratyphoid fever and typhoid fever) as a national notifiable condition. In addition, Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae (CP-CRE) represents a consolidation of CP-CRE species Klebsiella spp, CP-CRE E. coli, and CP-CRE Enterobacter spp. Publication criteria for the finalized 2019 data are available at https://wonder.cdc.gov/nndss/documents/2019_NNDSS _Publication_Criteria_01212021.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  3. Population estimates for incidence rates are July 1st, 2019, estimates obtained from the National Center for Health Statistics (NCHS) postcensal estimates of the resident population of the United States for April 1, 2010, to July 1, 2019, by year, county, single year of age (range: 0 to 85 years), bridged-race (white, black or African American, American Indian or Alaska Native, Asian, or Pacific Islander), Hispanic ethnicity (not Hispanic or Latino, Hispanic or Latino), and sex (Vintage 2019), prepared under a collaborative arrangement with the U.S. Census Bureau. Population estimates for states released July 9, 2020, are available at https://www.cdc.gov/nchs/nvss/bridged_race/data_documentation.htm. Population estimates for territories are the 2019 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on August 6, 2020, at https://www.census.gov/data-tools/demo/idb/#/country?YR_ANIM=2021. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  4. Annual tables for 2016 and later years are available on CDC WONDER.
  5. Annual summary reports from 1993–2015 are available as published in the Morbidity and Mortality Weekly Report.
  6. NNDSS annual tables since 1952 are available at CDC Stacks (once in CDC Stacks, select "Annual Reports" in the "Genre" box to the left).
  7. For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a national notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations.

    Age restrictions in the numerator and denominator are applied for the following childhood conditions:

    • Zika virus disease, congenital (age restriction in numerator and denominator is <1 year)
    • Zika virus infection, congenital (age restriction in numerator and denominator is <1 year)
    • Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years)
    • Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years)
    • Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years)
    • Infant botulism (age restriction in numerator and denominator is <1 year)
    • Congenital rubella syndrome (age restriction in numerator and denominator is <1 year)
    • Perinatal Hepatitis B infection (age restriction in numerator is ≤24 months, denominator is <24 months)
    • Perinatal Hepatitis C infection (age restriction in numerator is ≤36 months, denominator is <36 months).

    Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2019 (National Center for Health Statistics Natality 2019, as compiled from data provided by the Vital Statistics Cooperative Program). The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases. Congenital syphilis data are published in Syphilis Statistics in the sexually transmitted diseases (STD) surveillance report (https://www.cdc.gov/std/syphilis/stats.htm) and in the historical archives of the STD surveillance report (https://www.cdc.gov/std/stats/archive.htm). The STD surveillance report (https://www.cdc.gov/std/syphilis/stats.htm) updates congenital syphilis cases and rates over time.

  8. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC).
  9. The following 24 jurisdictions may have incomplete data, due to the coronavirus disease 2019 (COVID-19) pandemic: Alaska, California, Connecticut, Delaware, District of Columbia, Florida, Idaho, Indiana, Kansas, Massachusetts, Minnesota, Missouri, Montana, Nebraska, New Hampshire, New York (excluding New York City), New York City, North Dakota, Ohio, Oklahoma, South Carolina, Tennessee, Texas, and West Virginia. In addition, the following 2 U.S. Territories may have incomplete data due to the COVID-19 pandemic: American Samoa and the U.S. Virgin Islands.
Suggested Citation: Acknowledgment:
  • CDC acknowledges the local, state, and territorial health departments that collected the data from a range of case ascertainment sources (e.g., healthcare providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System.