Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 2g. Annual reported cases* of notifiable diseases, by region and reporting area, United States, U.S. Territories, and Non-U.S. Residents, 2022†
Reporting Area Giardiasis Gonorrhea Haemophilus influenzae, invasive disease Hansen's disease
All ages, all serotypes Age <5 years
Serotype b Non-b serotype Nontypeable Unknown serotype
U.S. Residents, excluding U.S. Territories 13,819 648,010 5,336 17 140 254 273 62
New England 1,034 17,086 239 1 6 15 4 1
Connecticut 182 4,979 54 — 2 — — —
Maine 99 621 30 — — 2 — N
Massachusetts 611 9,206 111 1 2 9 2 —
New Hampshire 83 662 27 — 2 — 1 1
Rhode Island 59 1,444 8 — — 2 1 —
Vermont N 174 9 — — 2 — N
Middle Atlantic 2,802 71,543 719 5 13 28 25 9
New Jersey 357 9,330 138 — — — 13 1
New York (excluding New York City) 898 14,061 185 2 2 14 3 N
New York City 958 29,301 139 1 9 1 4 5
Pennsylvania 589 18,851 257 2 2 13 5 3
East North Central 1,480 86,923 1,091 4 35 46 30 6
Illinois N 26,442 270 2 3 15 4 —
Indiana 169 12,396 195 1 13 7 3 2
Michigan 398 16,378 247 — 4 2 17 2
Ohio 495 22,969 270 1 11 19 5 2
Wisconsin 418 8,738 109 — 4 3 1 —
West North Central 1,125 39,877 374 1 6 2 40 3
Iowa 169 4,466 1 — — 1 — 2
Kansas 118 4,997 55 — 3 1 — 1
Minnesota 472 8,152 122 — — — 15 —
Missouri 190 15,209 126 — — — 20 —
Nebraska 85 2,560 33 — — — 3 —
North Dakota 27 1,426 12 — — — 2 N
South Dakota 64 3,067 25 1 3 — — —
South Atlantic 2,437 149,098 1,268 1 9 39 82 10
Delaware 29 1,464 25 — — — 2 —
District of Columbia — 4,925 10 — — — 1 —
Florida 1,178 44,333 340 — 2 19 16 8
Georgia 549 31,450 231 1 4 — 26 1
Maryland 188 11,164 110 — 1 1 8 1
North Carolina N 26,715 218 — 1 11 5 —
South Carolina 131 14,352 117 — — — 12 —
Virginia 270 13,437 160 — — 6 10 —
West Virginia 92 1,258 57 — 1 2 2 N
East South Central 302 47,057 392 — 19 17 30 3
Alabama 162 13,274 137 — 6 8 14 —
Kentucky 140 6,781 62 — — — 11 1
Mississippi N 10,933 58 — 9 — 2 —
Tennessee N 16,069 135 — 4 9 3 2
West South Central 333 92,780 675 1 27 61 24 15
Arkansas 117 6,792 79 — 1 7 4 —
Louisiana 216 15,015 88 — — 4 8 1
Oklahoma N 8,974 115 — 4 10 3 N
Texas N 61,999 393 1 22 40 9 14
Mountain 1,188 42,713 392 1 6 14 17 4
Arizona 113 16,490 124 1 1 6 — 3
Colorado 511 8,784 104 — 3 7 1 —
Idaho 133 1,098 29 — 1 — 2 —
Montana 65 1,311 18 — — 1 2 —
Nevada 69 7,392 36 — — — 3 1
New Mexico 66 4,157 41 — 1 — 2 —
Utah 188 3,171 39 — — — 7 —
Wyoming 43 310 1 — — — — —
Pacific 3,118 100,933 186 3 19 32 21 11
Alaska 97 2,304 36 1 9 1 — —
California 2,390 80,257 39 2 3 16 18 5
Hawaii 26 1,478 19 — — — 3 6
Oregon 329 5,494 75 — 2 3 — N
Washington 276 11,400 17 — 5 12 — N
U.S. Territories 14 1,475 1 — — — — 3
American Samoa — 15 — — — — — —
Commonwealth of Northern Mariana Islands — 17 — — — — — —
Guam — 329 — — — — — 3
Puerto Rico 11 1,070 1 — — — — —
U.S. Virgin Islands 3 44 — — — — — —
Non-U.S. Residents 4 46 — — — — — —
Total 13,837 649,531 5,337 17 140 254 273 65
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
  • U: Unavailable — The data are unavailable.
  • * Cases are assigned to the reporting jurisdiction submitting the case to NNDSS if the case's country of usual residence is the United States, a U.S. territory, unknown, or country is not reported; otherwise, the case is assigned to the Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions because this data element is only available in the HL7 generic version 2 and disease-specific message mapping guides. If a jurisdiction sends data in legacy formats, they are not able to send this information. For further information on interpretation of these data, see https://www.cdc.gov/nndss/data-statistics/readers-guides/.
  • † To calculate rates, use the populations provided in Table 8. Note that calculation of rates for the following conditions uses population subgroups as described in note #7 and population counts presented in Table 8: Zika virus infection, congenital; Zika virus disease, congenital; Infant botulism; Congenital rubella syndrome; Perinatal Hepatitis B infection; Perinatal Hepatitis C infection; Haemophilus influenzae, invasive disease; Invasive pneumococcal disease; and Influenza-associated pediatric mortality. Also see Notes #3 and #7.
Notes:
  1. These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables. Source datasets for the 2022 annual tables were officially closed on March 29, 2024.
  2. The list of national notifiable Infectious diseases and conditions for 2022 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2022" for the notifiable condition list year, checking "Infectious" conditions, and clicking "Get Notifiable List by Year". Publication criteria for the finalized 2022 data are available at https://wonder.cdc.gov/nndss/documents/NNDSS_Publication_Criteria_2022.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  3. Population estimates for incidence rates are July 1st, 2022 postcensal estimates of the resident population of the United States for July 1, 2020, to July 1, 2022, by year, county, single year of age (range: 0 to 85+ years), bridged-race (American Indian or Alaska Native, Asian or Pacific Islander, Black or African American, White), Hispanic ethnicity (Hispanic or Latino, not Hispanic or Latino), and sex (Female, Male), prepared under a collaborative arrangement with the U.S. Census Bureau and the National Cancer Institute (NCI). The "Vintage 2022" population estimates for years 2020-2022 were released March 2024 by the National Cancer Institute at https://seer.cancer.gov/popdata/. For more information, see https://seer.cancer.gov/popdata/singleages.html Population estimates for territories are the 2022 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on May 02, 2024, at https://www.census.gov/data-tools/demo/idb/#/country?YR_ANIM=2022. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  4. Annual tables for 2016 and later years are available on CDC WONDER.
  5. Annual summary reports from 1993–2015 are available as published in the Morbidity and Mortality Weekly Report.
  6. NNDSS annual tables since 1952 are available at CDC Stacks. To find them, search for "NNDSS" under Collections. Once in NNDSS Collections, navigate to the "Genre" box on the left-hand side and select "Annual Reports".
  7. For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a national notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations.

    Age restrictions in the numerator and denominator are applied for the following childhood conditions:

    • Zika virus disease, congenital (age restriction in numerator and denominator is <1 year)
    • Zika virus infection, congenital (age restriction in numerator and denominator is <1 year)
    • Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years)
    • Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years)
    • Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years)
    • Infant botulism (age restriction in numerator and denominator is <1 year)
    • Congenital rubella syndrome (age restriction in numerator and denominator is <1 year)
    • Perinatal hepatitis B infection (age restriction is ≤24 months)
    • Perinatal hepatitis C infection (age restriction is ≤36 months).

    Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2022 (National Center for Health Statistics Natality 2022, as compiled from data provided by the Vital Statistics Cooperative Program). Congenital syphilis cases are usually assigned to the mother's state of residence at the time of delivery. The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases.

  8. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC).
  9. Disease data presented in the 2022 tables reflect impacts of the COVID-19 pandemic, such as changes in exposure-related behavior, healthcare-seeking behavior, disease reporting, and public health investigations.
Suggested Citation: Acknowledgment:
  • CDC acknowledges the local, state, and territorial health departments that collected the data from a range of case ascertainment sources (e.g., healthcare providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System.