Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 2i. Annual reported cases* of notifiable diseases, by region and reporting area, United States, U.S. Territories, and Non-U.S. Residents, 2022†
Reporting Area Human immunodeficiency virus diagnoses Influenza-associated pediatric mortality Invasive pneumococcal disease § Legionellosis Leptospirosis
All ages Age <5 years
Confirmed Probable Confirmed Probable
U.S. Residents, excluding U.S. Territories 37,663 116 17,916 446 1,078 39 7,512 62
New England 802 7 897 3 60 — 466 2
Connecticut 220 1 198 — 11 — 114 N
Maine 42 2 167 — 6 — 25 1
Massachusetts 439 4 311 1 29 — 209 N
New Hampshire 28 — 99 1 6 — 44 —
Rhode Island 69 — 78 1 7 — 60 1
Vermont 4 — 44 — 1 — 14 —
Middle Atlantic 4,278 12 2,320 117 159 2 1,440 18
New Jersey 1,093 1 491 50 40 — 235 2
New York (excluding New York City) 616 4 799 32 53 1 456 N
New York City 1,614 4 464 21 43 — 361 13
Pennsylvania 955 3 566 14 23 1 388 3
East North Central 3,703 23 3,093 89 179 9 1,733 11
Illinois 1,309 6 N N 31 1 378 4
Indiana 616 6 743 2 30 — 255 1
Michigan 631 1 848 13 49 1 368 2
Ohio 856 4 1,073 74 47 7 504 4
Wisconsin 291 6 429 — 22 — 228 —
West North Central 1,200 6 1,577 61 111 9 411 2
Iowa 123 — N N N N 45 N
Kansas 133 1 247 12 16 3 39 1
Minnesota 262 1 471 — 42 — 109 1
Missouri 512 — 487 44 28 5 157 —
Nebraska 91 2 188 5 15 1 33 —
North Dakota 38 — 75 — 6 — 4 —
South Dakota 41 2 109 — 4 — 24 —
South Atlantic 10,953 19 2,894 35 182 5 1,507 10
Delaware 128 — 93 — 2 — 19 1
District of Columbia 211 — 34 — 1 — 31 1
Florida 4,302 6 842 20 65 4 537 —
Georgia 2,514 2 728 — 38 — 163 1
Maryland 754 — 396 6 20 1 203 4
North Carolina 1,355 2 N N N N 178 2
South Carolina 718 4 455 6 19 — 109 —
Virginia 835 3 25 — 24 — 193 1
West Virginia 136 2 321 3 13 — 74 —
East South Central 2,416 13 1,516 26 74 4 361 1
Alabama 702 3 407 4 35 2 65 1
Kentucky 405 8 323 21 9 2 104 —
Mississippi 449 1 177 — 14 — 41 N
Tennessee 860 1 609 1 16 — 151 N
West South Central 6,453 14 2,175 85 175 8 499 —
Arkansas 305 1 272 1 21 — 53 —
Louisiana 856 5 336 20 23 — 64 —
Oklahoma 394 — N N 16 1 38 —
Texas 4,898 8 1,567 64 115 7 344 N
Mountain 2,138 9 3,119 28 119 2 377 —
Arizona 861 5 1,219 9 45 1 123 —
Colorado 433 1 755 5 27 1 102 N
Idaho 41 — N N 10 — 20 —
Montana 11 2 103 1 6 — 11 —
Nevada 530 — 342 2 4 — 30 —
New Mexico 94 1 429 — 11 — 32 —
Utah 155 — 233 11 15 — 50 —
Wyoming 13 — 38 — 1 — 9 —
Pacific 5,720 13 325 2 19 — 718 18
Alaska 38 — 248 2 12 — 2 —
California 4,861 5 N N N N 585 4
Hawaii 78 — 77 — 7 — 15 10
Oregon 251 3 N N N N 53 2
Washington 492 5 N N N N 63 2
U.S. Territories 380 — 4 — — — 7 262
American Samoa — — N N N N N —
Commonwealth of Northern Mariana Islands — — — — — — — —
Guam — — — — — — — —
Puerto Rico 365 — 4 — — — 4 262
U.S. Virgin Islands 15 — — — — — 3 —
Non-U.S. Residents — — — — — — — —
Total 38,043 116 17,920 446 1,078 39 7,519 324
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
  • U: Unavailable — The data are unavailable.
  • * Cases are assigned to the reporting jurisdiction submitting the case to NNDSS if the case's country of usual residence is the United States, a U.S. territory, unknown, or country is not reported; otherwise, the case is assigned to the Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions because this data element is only available in the HL7 generic version 2 and disease-specific message mapping guides. If a jurisdiction sends data in legacy formats, they are not able to send this information. For further information on interpretation of these data, see https://www.cdc.gov/nndss/data-statistics/readers-guides/.
  • † To calculate rates, use the populations provided in Table 8. Note that calculation of rates for the following conditions uses population subgroups as described in note #7 and population counts presented in Table 8: Zika virus infection, congenital; Zika virus disease, congenital; Infant botulism; Congenital rubella syndrome; Perinatal Hepatitis B infection; Perinatal Hepatitis C infection; Haemophilus influenzae, invasive disease; Invasive pneumococcal disease; and Influenza-associated pediatric mortality. Also see Notes #3 and #7.
  • § Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years.
Notes:
  1. These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables. Source datasets for the 2022 annual tables were officially closed on March 29, 2024.
  2. The list of national notifiable Infectious diseases and conditions for 2022 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2022" for the notifiable condition list year, checking "Infectious" conditions, and clicking "Get Notifiable List by Year". Publication criteria for the finalized 2022 data are available at https://wonder.cdc.gov/nndss/documents/NNDSS_Publication_Criteria_2022.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  3. Population estimates for incidence rates are July 1st, 2022 postcensal estimates of the resident population of the United States for July 1, 2020, to July 1, 2022, by year, county, single year of age (range: 0 to 85+ years), bridged-race (American Indian or Alaska Native, Asian or Pacific Islander, Black or African American, White), Hispanic ethnicity (Hispanic or Latino, not Hispanic or Latino), and sex (Female, Male), prepared under a collaborative arrangement with the U.S. Census Bureau and the National Cancer Institute (NCI). The "Vintage 2022" population estimates for years 2020-2022 were released March 2024 by the National Cancer Institute at https://seer.cancer.gov/popdata/. For more information, see https://seer.cancer.gov/popdata/singleages.html Population estimates for territories are the 2022 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on May 02, 2024, at https://www.census.gov/data-tools/demo/idb/#/country?YR_ANIM=2022. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  4. Annual tables for 2016 and later years are available on CDC WONDER.
  5. Annual summary reports from 1993–2015 are available as published in the Morbidity and Mortality Weekly Report.
  6. NNDSS annual tables since 1952 are available at CDC Stacks. To find them, search for "NNDSS" under Collections. Once in NNDSS Collections, navigate to the "Genre" box on the left-hand side and select "Annual Reports".
  7. For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a national notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations.

    Age restrictions in the numerator and denominator are applied for the following childhood conditions:

    • Zika virus disease, congenital (age restriction in numerator and denominator is <1 year)
    • Zika virus infection, congenital (age restriction in numerator and denominator is <1 year)
    • Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years)
    • Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years)
    • Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years)
    • Infant botulism (age restriction in numerator and denominator is <1 year)
    • Congenital rubella syndrome (age restriction in numerator and denominator is <1 year)
    • Perinatal hepatitis B infection (age restriction is ≤24 months)
    • Perinatal hepatitis C infection (age restriction is ≤36 months).

    Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2022 (National Center for Health Statistics Natality 2022, as compiled from data provided by the Vital Statistics Cooperative Program). Congenital syphilis cases are usually assigned to the mother's state of residence at the time of delivery. The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases.

  8. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC).
  9. Disease data presented in the 2022 tables reflect impacts of the COVID-19 pandemic, such as changes in exposure-related behavior, healthcare-seeking behavior, disease reporting, and public health investigations.
Suggested Citation: Acknowledgment:
  • CDC acknowledges the local, state, and territorial health departments that collected the data from a range of case ascertainment sources (e.g., healthcare providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System.