Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 8. Population Denominators by Age Subgroup for Rate Calculations, United States and U.S. Territories, 2022
Reporting Area Total Resident Population US Resident Population, by Age Subgroup Live Births in Year 2022¶
Age <1 year* Age <5 years† Age <18 years§
United States 333,287,557 3,683,113 18,538,353 72,450,827 3,613,647
New England 15,129,548 147,104 730,185 2,887,955 138,452
Connecticut 3,626,205 35,870 181,607 731,030 33,460
Maine 1,385,340 12,002 61,744 247,898 11,539
Massachusetts 6,981,974 70,623 343,596 1,337,434 66,428
New Hampshire 1,395,231 12,713 62,944 252,924 11,791
Rhode Island 1,093,734 10,532 52,700 203,912 10,101
Vermont 647,064 5,364 27,594 114,757 5,133
Middle Atlantic 41,910,858 449,208 2,246,877 8,607,862 437,985
New Jersey 9,261,699 102,910 516,455 1,994,109 97,954
New York (excluding New York City) 11,341,254 114,021 586,153 2,310,265 112,697
New York City 8,335,897 100,725 473,064 1,679,023 96,641
Pennsylvania 12,972,008 131,552 671,205 2,624,465 130,693
East North Central 47,097,779 505,584 2,595,755 10,207,928 505,773
Illinois 12,582,032 131,093 680,341 2,720,131 133,298
Indiana 6,833,037 79,786 404,946 1,569,923 78,616
Michigan 10,034,113 104,605 536,425 2,109,695 104,074
Ohio 11,756,058 128,822 661,421 2,562,550 129,191
Wisconsin 5,892,539 61,278 312,622 1,245,629 60,594
West North Central 21,689,816 251,207 1,277,232 4,953,008 248,528
Iowa 3,200,517 36,786 186,200 724,489 36,114
Kansas 2,937,150 34,772 175,442 690,832 34,376
Minnesota 5,717,184 64,755 330,126 1,294,162 63,443
Missouri 6,177,957 69,009 353,605 1,364,908 69,285
Nebraska 1,967,923 24,347 123,837 476,677 24,291
North Dakota 779,261 10,093 49,929 182,775 10,059
South Dakota 909,824 11,445 58,093 219,165 10,960
South Atlantic 67,452,940 726,447 3,638,921 14,117,251 704,470
Delaware 1,018,396 10,785 53,766 208,127 10,392
District of Columbia 671,803 8,261 39,099 124,475 8,874
Florida 22,244,823 220,782 1,106,804 4,296,354 209,671
Georgia 10,912,876 124,954 631,545 2,510,123 122,473
Maryland 6,164,660 69,158 349,844 1,346,589 68,554
North Carolina 10,698,973 121,554 596,490 2,294,879 116,730
South Carolina 5,282,634 56,849 285,883 1,117,872 55,704
Virginia 8,683,619 96,728 487,493 1,866,910 94,749
West Virginia 1,775,156 17,376 87,997 351,922 17,323
East South Central 19,578,002 226,200 1,132,951 4,332,335 223,477
Alabama 5,074,296 57,882 290,299 1,111,562 57,647
Kentucky 4,512,310 52,123 262,713 1,004,575 51,668
Mississippi 2,940,057 34,735 174,518 678,061 35,473
Tennessee 7,051,339 81,460 405,421 1,538,137 78,689
West South Central 41,685,250 519,157 2,606,719 10,168,296 508,392
Arkansas 3,045,637 35,980 180,389 697,119 35,251
Louisiana 4,590,241 56,702 280,020 1,061,693 57,328
Oklahoma 4,019,800 47,793 243,671 953,146 47,623
Texas 30,029,572 378,682 1,902,639 7,456,338 368,190
Mountain 25,514,320 282,280 1,423,641 5,712,755 278,151
Arizona 7,359,197 78,579 395,006 1,589,010 76,947
Colorado 5,839,926 62,867 309,020 1,215,575 61,494
Idaho 1,939,033 22,368 113,283 463,404 21,533
Montana 1,122,867 11,201 57,646 233,753 10,791
Nevada 3,177,772 33,611 174,244 689,778 33,653
New Mexico 2,113,344 20,830 110,028 459,513 21,903
Utah 3,380,800 46,679 233,074 931,608 45,702
Wyoming 581,381 6,145 31,340 130,114 6,128
Pacific 53,229,044 575,926 2,886,072 11,463,437 568,419
Alaska 733,583 9,490 46,805 176,523 9,469
California 39,029,342 425,149 2,127,764 8,506,027 420,259
Hawaii 1,440,196 15,804 79,600 297,326 15,785
Oregon 4,240,137 41,052 206,074 836,988 39,820
Washington 7,785,786 84,431 425,829 1,646,573 83,086
U.S. Territories 3,469,840 30,080 147,618 624,533 23,372
American Samoa 45,443 689 3,518 13,312 —
Commonwealth of Northern Mariana Islands 51,475 782 3,769 15,169 628
Guam 169,086 3,103 15,401 53,665 2,935
Puerto Rico 3,098,423 24,278 118,549 518,243 18,933
U.S. Virgin Islands 105,413 1,228 6,381 24,144 876
  • * Use this population for Zika virus disease, congenital; Zika virus infection, congenital; infant botulism; and congenital rubella syndrome.
  • † Use this population for Haemophilus influenzae, invasive disease and invasive pneumococcal disease.
  • § Use this population for influenza associated pediatric mortality.
  • ¶ Use this population for congenital syphilis.
  • Please also see note #7 .
Notes:
  1. These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables. Source datasets for the 2022 annual tables were officially closed on March 29, 2024.
  2. The list of national notifiable Infectious diseases and conditions for 2022 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2022" for the notifiable condition list year, checking "Infectious" conditions, and clicking "Get Notifiable List by Year". Publication criteria for the finalized 2022 data are available at https://wonder.cdc.gov/nndss/documents/NNDSS_Publication_Criteria_2022.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  3. Population estimates for incidence rates are July 1st, 2022 postcensal estimates of the resident population of the United States for July 1, 2020, to July 1, 2022, by year, county, single year of age (range: 0 to 85+ years), bridged-race (American Indian or Alaska Native, Asian or Pacific Islander, Black or African American, White), Hispanic ethnicity (Hispanic or Latino, not Hispanic or Latino), and sex (Female, Male), prepared under a collaborative arrangement with the U.S. Census Bureau and the National Cancer Institute (NCI). The "Vintage 2022" population estimates for years 2020-2022 were released March 2024 by the National Cancer Institute at https://seer.cancer.gov/popdata/. For more information, see https://seer.cancer.gov/popdata/singleages.html Population estimates for territories are the 2022 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on May 02, 2024, at https://www.census.gov/data-tools/demo/idb/#/country?YR_ANIM=2022. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  4. Annual tables for 2016 and later years are available on CDC WONDER.
  5. Annual summary reports from 1993–2015 are available as published in the Morbidity and Mortality Weekly Report.
  6. NNDSS annual tables since 1952 are available at CDC Stacks. To find them, search for "NNDSS" under Collections. Once in NNDSS Collections, navigate to the "Genre" box on the left-hand side and select "Annual Reports".
  7. For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a national notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations.

    Age restrictions in the numerator and denominator are applied for the following childhood conditions:

    • Zika virus disease, congenital (age restriction in numerator and denominator is <1 year)
    • Zika virus infection, congenital (age restriction in numerator and denominator is <1 year)
    • Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years)
    • Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years)
    • Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years)
    • Infant botulism (age restriction in numerator and denominator is <1 year)
    • Congenital rubella syndrome (age restriction in numerator and denominator is <1 year)
    • Perinatal hepatitis B infection (age restriction is ≤24 months)
    • Perinatal hepatitis C infection (age restriction is ≤36 months).

    Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2022 (National Center for Health Statistics Natality 2022, as compiled from data provided by the Vital Statistics Cooperative Program). Congenital syphilis cases are usually assigned to the mother's state of residence at the time of delivery. The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases.

  8. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC).
  9. Disease data presented in the 2022 tables reflect impacts of the COVID-19 pandemic, such as changes in exposure-related behavior, healthcare-seeking behavior, disease reporting, and public health investigations.
Suggested Citation: Acknowledgment:
  • CDC acknowledges the local, state, and territorial health departments that collected the data from a range of case ascertainment sources (e.g., healthcare providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System.