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Sexually Transmitted Disease Surveillance 1994

Division of STD Prevention

September 1995

U.S. Department of Health and Human Services
Public Health Service
Centers for Disease Control and Prevention 
National Center for HIV, STD, and TB Prevention (proposed)
Division of STD Prevention
Atlanta, Georgia 30333

                         Copyright Information 

All material contained in this report is in the public domain and may be
used and reprinted without special permission; citation to source, however,
is appreciated.

                           Suggested Citation

Division of STD Prevention. Sexually Transmitted Disease Surveillance,
1994. U.S. Department of Health and Human Services, Public Health Service.
Atlanta: Centers for Disease Control and Prevention, September 1995.

Copies can be obtained from Information Technology and Services Office,
National Center for HIV, STD, and TB Prevention (proposed), Centers for
Disease Control and Prevention, 1600 Clifton Road, Mailstop E-06, Atlanta,
Georgia 30333 or by telephone at (404) 639-1819.

Both the 1993 and 1994 reports are now available electronically on CDC
WONDER. For information about registering for CDC WONDER, please contact
CDC's Information Resource Management Office at (404) 332-4569.

                            National Profile

The National Profile section contains figures showing trends and
distribution of sexually transmitted diseases (STDs) by age, gender,
race/ethnicity, and location for the United States. Where relevant, the
figures illustrate progress toward specific year 2000 goals for the nation
published in Healthy People 2000: National Health Promotion and Disease
Prevention Objectives.

                                Chlamydia

Infections due to Chlamydia trachomatis are among the most prevalent of all
sexually transmitted diseases. In women these infections often result in
serious reproductive tract complications, such as pelvic inflammatory
disease, infertility, and ectopic pregnancy. In addition, infected pregnant
women can infect their babies during delivery. While surveillance of
chlamydial infections is improving, it remains incomplete in many areas of
the country. A combination of factors limit the documentation of the
incidence and prevalence of genital chlamydial infection:  variable
compliance with public health laws and regulations that require health care
providers and laboratories to report cases to local health authorities;
large numbers of asymptomatic persons who can be identified only through
screening; limited resources to support screening activities; and
incompletely developed information management infrastructures for
collecting, maintaining, and analyzing morbidity data. Thus, for most
areas, the number of reported chlamydia cases reported to CDC by state
health departments reflects the degree of local interest in chlamydia as a
public health problem and initial attempts to resolve reporting limitations
rather than true disease burden or trends.

 --  In 1994, 448,984 chlamydial infections were reported to CDC from 47
     states (Table_3). This is the first year that reported cases of
     chlamydia exceeded reported cases of gonorrhea (418,068 gonorrhea
     cases in 1994, Table_1).

 --  From 1984 through 1994 reported rates of chlamydia increased
     dramatically, from 3.2 cases per 100,000 population to 188.4
     (Figure_1). Trends continue to primarily reflect increased
     screening, recognition of asymptomatic infection (mainly in women),
     and improved reporting capacity rather than true trends in disease
     incidence.

 --  As in previous years, rates of chlamydia were highest in the West and
     the Midwest, where substantial resources have been committed for
     organized screening programs (e.g., in family planning clinics)
     (Figure_2 and Figure_3). In the areas where these screening
     programs are in place, chlamydia rates far exceed gonorrhea rates.

 --  Between 1993 and 1994 rates of chlamydia reported from large cities
     (>200,000 population) increased 17% from 280.7 cases per 100,000
     population to 328.4 (Figure_4, Table_6).

 --  Reported rates of chlamydia for women (265.3 per 100,000 population)
     exceed those for men (46.2 per 100,000 population) (Figure_5,
     Table_4, Table_5, Table_7, and Table_8). This is
     mainly due to increased detection of asymptomatic infection in women
     through screening. The low rates in men suggest that many of the sex
     partners of women with chlamydia are not diagnosed or reported. In
     addition, men diagnosed as having non-gonococcal urethritis are
     treated but frequently not tested. A large proportion of these men are
     infected with chlamydia, but they are not detected by surveillance
     systems based on laboratory reporting of positive chlamydia tests.

 --  Additional information on chlamydia screening programs in women and
     chlamydia in adolescents and minority populations can be found in the
     Special Focus Profiles section.


Figure_1. Chlamydia - Reported rates: United States, 1984-1994    
Figure_2. Chlamydia - Rates by state: United States, 1994    
Figure_3. Chlamydia - Rates by region: United States, 1984-1994    
Figure_4. Chlamydia - Rates in U.S. cities of >200,000 population,
              1984-1994
Figure_5. Chlamydia - Rates by gender: United States, 1984-1994    
                                    
                                Gonorrhea

 --  In 1994, 418,068 cases of gonorrhea were reported. The rate of
     gonorrhea has continued its overall decline since 1975. Between 1993
     and 1994 the rate decreased from 173.8 cases per 100,000 population in
     1993 to 168.4 (Table_1 and Figure_6). However, the state of
     Georgia did not report in 1994. In previous years, Georgia has
     reported among the highest rates of gonorrhea; thus, exclusion of
     Georgia lowered the overall rate for the nation in 1994 (see
     Appendix).

 --  In 1994, 37 states reported gonorrhea rates below the Healthy People
     2000 (HP2000) national objective of 225 cases per 100,000 population
     (Figure_7 and Table_10). However, gonorrhea rates increased
     between 1993 and 1994 in 21 of 35 states reporting more than 1,000
     cases in 1994. This trend was decidedly different from recent years of
     steep declines in most states (Table_11) (1).

 --  The decrease in gonorrhea rates slowed in 1994 for the West,
     Northeast, and South. The rate increased for the Midwest from 176.0
     cases per 100,000 population in 1993 to 181.4 in 1994. (Figure_8).

 --  Although the overall gonorrhea rate for large cities (with >200,000
     population) continued to decline in 1994 (Figure_9), 39 (62%) of
     63 large cities (excluding Atlanta, see Appendix) had rates exceeding
     the HP2000 objective (Table_14). The same number of large cities
     had rates exceeding the HP2000 objective in 1993.

 --  The gonorrhea rate for men continued to decline in 1994, but increased
     in women  from 147.1 per 100,000 population to 153.7. Rates for both
     men and women remained below the HP2000 objective (Figure_10;
     Table_12, Table_13, Table_16, and Table_17).

 --  In 1994, gonorrhea rates increased slightly for all racial and ethnic
     groups except Hispanics (Figure_11 and Table_9B). However,
     rates for all racial and ethnic groups except non-Hispanic blacks
     remained below the HP2000 objective (Figure_11 and Table_9B).
     The gonorrhea rate for blacks increased from 1,215.2 cases per 100,000
     population in 1993 to 1,219.3 in 1994, but remained below the HP2000
     sub-objective of 1,300 cases per 100,000 population for the second
     year in a row in this special target group (Table_9B).

 --  Between 1993 and 1994, the gonorrhea rate for 15- to 19-year-old
     adolescents increased nearly 3% from 742.1 cases per 100,000
     population to 763.4 and exceeded the HP2000 sub-objective of 750 cases
     per 100,000 population for this special target population
     (Table_9B).

 --  Antimicrobial resistance remains an important consideration in the
     treatment of gonorrhea. Overall, 30.5% of isolates collected in 1994
     by the Gonococcal Isolate Surveillance Project (GISP) were resistant
     to penicillin, tetracycline, or both (Figure_14). Between 1991 and
     1994, the percentage of GISP isolates that were penicillinase-
     producing Neisseria gonorrhoeae (PPNG), declined from 13.1% to 7.8%
     (Figure_15). In contrast, isolates with chromosomally mediated
     resistance increased from 13.9% in 1990 to 16.2% in 1994
     (Table_18). Although no GISP isolates have yet demonstrated
     clinically significant resistance to the antimicrobial agents
     currently recommended for therapy (2), some isolates have begun to
     demonstrate decreased levels of susceptibility to some of these agents
     (3).

 --  Additional information about gonorrhea in racial and ethnic minority
     populations and adolescents can be found in the Special Focus Profiles
     section.

(1) CDC. Increasing incidence of gonorrhea -- Minnesota, 1994. MMWR
1995;44:282-6.

(2) CDC. 1993 Sexually transmitted diseases treatment guidelines MMWR
1993;42(No. RR-14):56-66.

(3) CDC. Decreased susceptibility of Neisseria gonorrhoeae to
fluoroquinolones -- Ohio and Hawaii, 1992-1994. MMWR 1994;43:325-7.

Figure_6.  Gonorrhea - Reported rates: United States, 1970-1994 and the
               year 2000 objective   
Figure_7.  Gonorrhea - Rates by state: United States, 1994   
Figure_8.  Gonorrhea - Rates by region: United States, 1981-1994 and
               the year 2000 objective   
Figure_9.  Gonorrhea - Rates in U.S. cities of >200,000 population,
               1981-1994 and the year 2000 objective   
Figure_10. Gonorrhea - Rates by gender: United States, 1981-1994 and
               the year 2000 objective   
Figure_11. Gonorrhea - Rates by race and ethnicity: United States,
               1981-1994 and the year 2000 objective   
Figure_12. Gonorrhea - Age- and gender-specific rates: United States,
               1994   
Figure_13. Gonococcal Isolate Surveillance Project (GISP) - Location of
               participating clinics and regional laboratories: United
               States, 1994
Figure_14. Gonococcal Isolate Surveillance Project (GISP) - Percentage
               distribution of antimicrobial resistance in gonorrhea
               isolates, 1994
Figure_15. Gonococcal Isolate Surveillance Project (GISP) - Trends in
               plasmid-mediated resistance, 1988-1994    
Figure_16. Gonococcal Isolate Surveillance Project (GISP) - Trends in
               chromosomally mediated resistance, 1988-1994    

                                Syphilis

 --  In 1994, 20,627 cases of primary and secondary (P&S) syphilis were
     reported to CDC. This is the fewest cases reported since 1977. Between
     1993 and 1994, the incidence of primary and secondary syphilis in the
     United States declined from 10.4 to 8.1 cases per 100,000 population
     (Figure_18 and Table_1).

 --  In 1994, P&S syphilis rates were below the Healthy People 2000
     (HP2000) national objective of 10 cases per 100,000 population in 38
     states (Figure_19 and Table_22). Ten states reported no or
     fewer than 5 cases of P&S syphilis in 1994.

 --  In 1994, 2,105 (68%) of 3,116 counties in the United States reported
     no cases of P&S syphilis compared with 2,006 (64%) counties in 1993.
     Of 1,011 counties reporting at least one case of P&S syphilis in 1994,
     615 (61%) counties reported rates of 10 cases or less per 100,000
     population (Figure_20). The rates of P&S syphilis were above the
     HP2000 objective for 396 counties in 1994 compared with 461 counties
     in 1993. These counties (13% of the total counties in the United
     States) accounted for 77% of all reported P&S syphilis cases.

 --  In 1994, the rates of P&S syphilis continued to decline for all
     regions of the United States. However, the rate of 15.3 cases per
     100,000 population in the South remained above the HP2000 objective
     (Figure_21).

 --  The overall rate of P&S syphilis in large cities (>200,000 population)
     declined from 17.8 cases per 100,000 population in 1993 to 12.7 in
     1994 (Figure_22 and Table_27). However, rates exceeded the
     HP2000 objective in 30 (47%) of 64 large cities in the United States
     and outlying areas for which data were available (Table_26).

 --  Since 1990, the rates of P&S syphilis have declined for all racial and
     ethnic groups (Figure_24 and Table_21B). However, the 1994
     rate for non-Hispanic blacks of 59.5 cases per 100,000 population was
     60 times greater than the rate for non-Hispanic whites (Figure_24
     and Table_21B).

 --  Between 1993 and 1994, the overall rate of congenital syphilis
     decreased from 80.7 to 55.6 cases per 100,000 live births
     (Figure_27, Table_34). However, compared with 1993, increases
     were seen in 1994 in eight of the 28 states reporting more than five
     cases (Arkansas, Indiana, Iowa, Kentucky, New Jersey, Oklahoma, South
     Carolina, and Tennessee) (Table_35).

 --  In 1994, 11 states (Arkansas, Illinois, Louisiana, Mississippi,
     Missouri, New Jersey, New York, Pennsylvania, South Carolina,
     Tennessee, and Texas) had congenital syphilis rates that exceeded the
     HP2000 objective of 50 cases per 100,000 live births (Table_35).

 --  Additional information on syphilis and congenital syphilis can be
     found in the Special Focus Profiles section.


Figure_17. Syphilis - Reported cases by stage of illness: United
               States, 1941-1994    
Figure_18. Primary and secondary syphilis - Reported rates: United
               States, 1970-1994 and the year 2000 objective    
Figure_19. Primary and secondary syphilis - Rates by state: United
               States, 1994
Figure_20. Primary and secondary syphilis - Counties with rates above
               and counties with rates below the year 2000 objective:
               United States, 1994   
Figure_21. Primary and secondary syphilis - Rates by region: United
               States, 1981-1994 and the year 2000 objective   
Figure_22. Primary and secondary syphilis - Rates in U.S. cities of
               >200,000 population, 1981-1994 and the year 2000 objective
Figure_23. Primary and secondary syphilis - Rates by gender: United
               States, 1981-1994 and the year 2000 objective    
Figure_24. Primary and secondary syphilis - Rates by race and
               ethnicity: United States, 1981-1994 and the year 2000
               objective    
Figure_25. Primary and secondary syphilis - Age- and gender-specific
               rates: United States: 1994    
Figure_26. Congenital syphilis - Reported cases in infants <1 year of
               age and rates of primary and secondary syphilis among women:
               United States, 1970-1994    
Figure_27. Congenital syphilis - Rates in infants <1 year of age:
               United States, 1981-1994   

                   Other Sexually Transmitted Diseases

 --  Hospitalizations for acute and chronic pelvic inflammatory disease
     (PID) have continued to decline since the early 1980's
     (Figure_28). However, initial visits to physicians' offices for
     PID have remained relatively constant (Figure_29).

 --  Since 1987, reported cases of chancroid have declined steadily
     (Table_1, Figure_31).

 --  Comprehensive surveillance data for non-specific urethritis, viral
     STDs, and vaginitis are not available. Ongoing trend data are limited
     to estimates of trends in physicians' office practices provided by the
     National Disease and Therapeutic Index. These data suggest that these
     diseases affect large numbers of persons each year (Figure_30,
     Figure_32, Figure_33, and Figure_34).

Figure_28. Pelvic inflammatory disease - Hospitalizations of women
               15-44 years of age: United States, 1980-1993
Figure_29. Pelvic inflammatory disease - Initial visits to physicians'
               offices by women 15-44 years of age: United States, 1980-
               1993    
Figure_30. Nonspecific urethritis - Initial visits to physicians'
               offices by men: United States, 1966-1993    
Figure_31. Chancroid - Reported cases: United States, 1981-1994    
Figure_32. Human papillomavirus (genital warts) - Initial visits to
               physicians' offices: United States, 1966-1993    
Figure_33. Genital herpes simplex virus infections - Initial visits to
               physicians' offices: United States, 1966-1993    
Figure_34. Trichomonal and other vaginal infections - Initial visits to
               physicians' offices: United States, 1966-1993    



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