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TABLE 1. Oral desensitization protocol for patients with a positive skin test *
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Penicillin V Amount & Cumulative
suspension dose + (units/mL) mL Units dose (units)
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1 1,000 0.1 100 100
2 1,000 0.2 200 300
3 1,000 0.4 400 700
4 1,000 0.8 800 1,500
5 1,000 1.6 1,600 3,100
6 1,000 3.2 3,200 6,300
7 1,000 6.4 6,400 12,700
8 10,000 1.2 12,000 24,700
9 10,000 2.4 24,000 48,700
10 10,000 4.8 48,000 96,700
11 80,000 1.0 80,000 176,700
12 80,000 2.0 160,000 336,700
13 80,000 4.0 320,000 656,700
14 80,000 8.0 640,000 1,296,700
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Observation period: 30 minutes before parenteral administration of penicillin.
* Reprinted with permission from the New England Journal of Medicine (24).
+ Interval between doses, 15 minutes; elapsed time, 3 hours and 45 minutes; cumulative dose,
1.3 million units.
& The specific amount of drug was diluted in approximately 30 mL of water and then adminis-
tered orally.
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