Warning:

This document is being maintained for historical purposes, but is now out of date. To view current guidelines please visit:

• STD Treatment Guidelines   at http://www.cdc.gov/STD/treatment

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Table_1

TABLE 1. Oral desensitization protocol for patients with a positive skin test (15) *
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Penicillin V                                                            
suspension      Amount &                                   Cumulative
dose +         (units/mL)          mL          Units      dose (units)
----------------------------------------------------------------------     
 1                1,000            0.1            100            100
 2                1,000            0.2            200            300
 3                1,000            0.4            400            700
 4                1,000            0.8            800          1,500
 5                1,000            1.6          1,600          3,100
 6                1,000            3.2          3,200          6,300
 7                1,000            6.4          6,400         12,700
 8               10,000            1.2         12,000         24,700
 9               10,000            2.4         24,000         48,700
10               10,000            4.8         48,000         96,700
11               80,000            1.0         80,000        176,700
12               80,000            2.0        160,000        336,700
13               80,000            4.0        320,000        656,700
14               80,000            8.0        640,000      1,296,700
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Observation period: 30 minutes before parenteral administration of penicillin.

* Reprinted with permission from the New England Journal of Medicine.
+ Interval between doses, 15 minutes; elapsed time, 3 hours and 45 minutes; cumulative dose,
  1.3 million units.
& The specific amount of drug was diluted in approximately 30 mL of water and then adminis-
  tered orally.
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