CDC Prevention Guidelines Database (Archive)
Preventing Dengue Fever in Travelers
Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Dengue Branch (809)766-5181 FAX (809)766-6596 internet: firstname.lastname@example.org
Publication date: 11/01/1995
Table of Contents
PREVENTING DENGUE FEVER IN TRAVELERSTravelers may acquire dengue fever, a potentially life-threatening viral illness, during visits to tropical and subtropical countries. Dengue is transmitted by the bite of infective Aedes mosquitos which are found primarily in urban areas. This disease occurs in most of tropical Asia, the Pacific Islands, the Caribbean Islands, Central and South America, and Africa. There is generally greater risk in urban areas and less risk of dengue in rural areas and at altitudes above 1500 meters (4500 feet).
Figure 1 Dengue infected regions of the World
Dengue fever and its symptomsDengue is characterized by sudden onset, high fever, severe headache, joint and muscle pain and rash. Nausea and vomiting, loss of appetite, and altered taste sensation are common. A rash may appear 3 to 4 days after onset of fever and may spread from the torso to the arms, legs, and face. The disease is usually benign and self-limiting after about 7 days. Dengue may also present as a severe and fatal hemorrhagic disease, called dengue hemorrhagic fever (DHF). There is no specific treatment for dengue infection.
TRAVELERS SHOULD ADVISE THEIR PHYSICIAN OF ANY ACUTE ILLNESS WITH FEVER OCCURRING WITHIN 3 WEEKS AFTER LEAVING A TROPICAL AREA
Dengue is a viral disease transmitted by urban Aedes mosquitos. The principal vector mosquito is Aedes aegypti, a species found living in close association with humans in most tropical urban areas. Mosquito biting activity is greatest in the morning for several hours after daybreak and in the late afternoon for several hours before dark. It may feed all day indoors, in shady areas, or when it is overcast. This mosquito breeds in artificial water containers, such as discarded tires, cans, barrels, buckets, 55 gallon drums, flower vases, and cisterns, all frequently found in the domestic environment. Since 1980, the incidence of dengue has increased dramatically in tropical countries worldwide, with endemic and/or epidemic virus transmission documented in most countries of the Caribbean Basin, Central and South America, the Pacific Islands, Asia, and Africa; many countries have had multiple outbreaks. Epidemics are frequently not reported because of inadequate disease surveillance.
Virus types and distributionThere are four dengue virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), and all are currently circulating in the Pacific Islands, Americas, Asia, and Africa. In the Americas, all but DEN-3 have widespread distribution. DEN-3 was only recently (October 1994) reintroduced into Central America and is now spreading throughout the region. Since this serotype has been absent from the region for 18 years, there is a low level of immunity and rapid spread is expected.
Risk to the travelerThe risk of dengue infection for the international traveler appears to be small, unless an epidemic is currently in progress. Current data suggest that the strain of dengue virus, and the age, immune status, and genetic background of the human host are important risk factors for developing DHF. In Asia, children under the age of 15 years who are experiencing a second dengue infection appear to have the highest risk of developing DHF. This suggests that most international travelers from nonendemic areas, such as the United States, have a low risk of developing DHF.
Protection against DengueNo vaccine is available for dengue, but travelers can protect themselves by using anti-mosquito measures to avoid being bitten.
General recommendations to avoid mosquito bites while traveling:
Note: Vitamin B and ultrasound devices are NOT effective in preventing mosquito bites.
- Apply insect repellent sparingly to exposed skin. An effective repellent will contain 20% to 30% DEET (N,N-diethyl-m-toluamide). DEET in high concentrations (>30%) may cause side effects, particularly in children.
- Avoid formulations containing > 30% DEET. Use aerosols in an open space to avoid inhalation. Avoid applying repellent to the hands of children.
- Wear long-sleeved clothing and long pants if you are outdoors during the day and evening.
- Spray permethrin or DEET repellents on clothing, as mosquitos may bite through thin clothing.
- Use mosquito netting over the bed if your bedroom is not air conditioned or screened. For additional protection, treat the mosquito netting with the insecticide permethrin.
- Spray permethrin or a similar insecticide in your bedroom before going to bed.
Reduce Your Risk for InfectionYour risk for becoming infected with dengue is lower if you:
- Spend most of your time in air conditioned buildings, hotels, or other closed circulation environments;
- Avoid highly populated residential areas;
- Spend time on beaches or in forested areas.
Think You Have Dengue?
Additional copies of this brochure may be obtained in bulk or as single copies free of charge from the Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases Centers for Disease Control and Prevention, Dengue Branch, 2 Calle Casia, San Juan, Puerto Rico 00921-3200 telephone (809) 766-5181; fax (809) 766-6596; Internet: email@example.com OR Division Headquarters,P.O. Box 2087, Fort Collins, CO 80522 telephone (970) 221-6400; fax (970) 221-6476 Internet: firstname.lastname@example.org
- Avoid analgesics with aspirin; use those with acetaminophen.
- Rest and drink plenty of fluids.
- Consult a physician.
POINT OF CONTACT FOR THIS DOCUMENT:To request a copy of this document or for questions concerning this document, please contact the person or office listed below. If requesting a document, please specify the complete name of the document as well as the address to which you would like it mailed. Note that if a name is listed with the address below, you may wish to contact this person via CDC WONDER/PC e-mail.
DIVISION OF VECTOR-BORNE INFECTIOUS DISEASES CDC/NCID/DVBID/DB
2 Calle Casia
San Juan, PR, 009213200
Dengue infected regions of the World