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National Notifiable Infectious Diseases and Conditions: United States

TABLE 1. Reported cases of notifiable diseases and rates per 100,000, excluding U.S. territories - - United States, 2016
Disease Case Count Rate
Anthrax — —
Arboviral diseases
Chikungunya virus disease 247 0.08
Eastern equine encephalitis virus disease
Neuroinvasive 7 0.00
Non-neuroinvasive — —
Jamestown Canyon virus disease
Neuroinvasive 7 0.00
Non-neuroinvasive 8 0.00
La Crosse virus disease
Neuroinvasive 31 0.01
Non-neuroinvasive 4 0.00
Powassan virus disease
Neuroinvasive 21 0.01
Non-neuroinvasive 1 0.00
St. Louis encephalitis virus disease
Neuroinvasive 7 0.00
Non-neuroinvasive 1 0.00
West Nile virus disease
Neuroinvasive 1,308 0.40
Non-neuroinvasive 841 0.26
Western equine encephalitis virus disease
Neuroinvasive — —
Non-neuroinvasive — —
Babesiosis
Total 1,910 0.83
Confirmed 1,585 0.69
Probable 325 0.14
Botulism
Total 201 0.06
Foodborne 31 0.01
Infant * 144 3.63
Other (wound & unspecified) 26 0.01
Brucellosis 127 0.04
Campylobacteriosis 60,120 18.61
Chancroid 7 0.00
Chlamydia trachomatis infection 1,598,354 494.65
Cholera 15 0.00
Coccidioidomycosis † 11,829 9.01
Cryptosporidiosis
Total 13,453 4.16
Confirmed 8,637 2.67
Probable 4,816 1.49
Cyclosporiasis 537 0.18
Dengue virus infections §
Dengue 903 0.28
Dengue-like illness 40 0.01
Severe dengue 10 0.00
Diphtheria — —
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection 4,151 1.33
Ehrlichia chaffeensis infection 1,377 0.44
Ehrlichia ewingii infection 22 0.01
Undetermined ehrlichiosis/anaplasmosis 200 0.06
Giardiasis 16,310 6.43
Gonorrhea 468,514 144.99
Haemophilus influenzae, invasive disease
All ages, all serotypes 4,895 1.51
Age <5 years ¶
Serotype b 30 0.15
Non-b serotype 159 0.80
Nontypeable 196 0.98
Unknown serotype 187 0.94
Hansen's disease 78 0.03
Hantavirus infection, non-hantavirus pulmonary syndrome 6 0.00
Hantavirus pulmonary syndrome 31 0.01
Hemolytic uremic syndrome post-diarrheal 307 0.10
Hepatitis **
A, acute 2,007 0.62
B, acute 3,218 1.00
B, perinatal infection †† 32 0.40
C, acute 2,942 0.97
Human immunodeficiency virus diagnoses 34,775 10.76
Influenza-associated pediatric mortality §§ 82 0.11
Invasive pneumococcal disease
All ages 17,626 7.32
Confirmed 17,603 7.31
Probable 23 0.01
Age <5 years ¶ 1,142 0.44
Confirmed 1,137 7.13
Probable 5 0.03
Legionellosis 6,141 1.90
Leptospirosis 78 0.03
Listeriosis 786 0.24
Lyme disease
Total 36,429 11.32
Confirmed 26,203 8.15
Probable 10,226 3.18
Malaria 1,955 0.61
Measles
Total 85 0.03
Indigenous 68 0.02
Imported 17 0.01
Meningococcal disease
All serogroups 375 0.12
Serogroups ACWY 126 0.04
Serogroup B 86 0.03
Other serogroups 21 0.01
Unknown serogroup 142 0.04
Mumps 6,369 1.97
Novel Influenza A virus infections 23 0.01
Pertussis 17,972 5.56
Plague 4 0.00
Poliomyelitis, paralytic — —
Poliovirus infection, nonparalytic — —
Psittacosis 12 0.00
Q fever
Total 164 0.05
Acute 132 0.04
Chronic 32 0.01
Rabies
Animal 4,609 1.51
Human — —
Rubella 1 0.00
Rubella, congenital syndrome * 2 0.05
Salmonellosis 53,850 16.67
Severe acute respiratory syndrome-associated coronavirus disease — —
Shiga toxin-producing Escherichia coli ¶¶ 8,169 2.53
Shigellosis 21,097 6.53
Smallpox — —
Spotted fever rickettsiosis
Total 4,269 1.33
Confirmed 154 0.05
Probable 4,115 1.28
Streptococcal toxic shock syndrome 283 0.14
Syphilis
Total, all stages *** 88,042 27.25
Congenital * 628 15.82
Primary and secondary 27,814 8.61
Tetanus 34 0.01
Toxic shock syndrome (other than Streptococcal) 40 0.02
Trichinellosis 26 0.01
Tuberculosis 9,272 2.87
Tularemia 230 0.07
Typhoid fever 376 0.12
Vancomycin-intermediate Staphylococcus aureus 108 0.04
Vancomycin-resistant Staphylococcus aureus — —
Varicella morbidity 8,953 3.45
Varicella mortality 3 0.00
Vibriosis
Total 1,273 0.40
Confirmed 1,241 0.39
Probable 32 0.01
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus — —
Ebola virus — —
Guanarito virus — —
Junin virus — —
Lassa virus — —
Lujo virus — —
Machupo virus — —
Marburg virus — —
Sabia virus — —
Yellow fever 1 0.00
Zika virus
Zika virus disease, congenital *,††† 30 0.76
Zika virus disease, non-congenital 5,132 1.59
Zika virus infection, congenital *,††† 45 1.13
Zika virus infection, non-congenital 911 0.28
    —: No reported cases
  • * The rate is calculated using population less than 1 year of age.
  • † Reportable in <25 states.
  • § Total number of reported laboratory-positive dengue cases, including all confirmed cases [by anti-dengue virus (DENV) molecular diagnostic methods or seroconversion of anti-DENV IgM] and all probable cases (by a single, positive anti-DENV IgM).
  • ¶ The rate is calculated using population less than 5 years of age.
  • ** Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/2015surveillance/index.htm.
  • †† The rate is calculated using population less than 2 years of age.
  • §§ The rate is calculated using population less than 18 years of age.
  • ¶¶ Includes Escherichia coli O157:H7; shiga toxin-positive, serogroup non-O157; and shiga toxin positive, not serogrouped.
  • *** Includes syphilis of all stages, including cases where stage of syphilis is not stated.
  • ††† Data reported to ArboNET using the national surveillance case definition for congenital Zika virus disease or infection (CSTE Position Statement 16-ID-01). Additional data reported to the US Zika Pregnancy Registry for outcomes of pregnancies with laboratory evidence of possible Zika virus infection are available at https://www.cdc.gov/zika/reporting/pregnancy-outcomes.html. Cases reported to the US Zika Pregnancy Registry might not meet the national surveillance case definition for congenital Zika virus disease or infection.
Notes:
  • These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables.
  • The list of national notifiable infectious diseases and conditions for 2016 and their national surveillance case definitions are available at https://wwwn.cdc.gov/nndss/conditions/notifiable/2016/infectious-diseases/. This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved in 2015 by CSTE for national surveillance, that were implemented in January 2016, including updated surveillance case definitions for acute hepatitis C and chronic hepatitis C virus infections. 2016 data are reported through June 30, 2017. Publication criteria for the finalized 2016 data are available at /nndss/documents/2016_NNDSS_Publication_Criteria.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  • Population estimates for incidence rates are July 1st, 2016 estimates obtained from the National Center for Health Statistics (NCHS) postcensal estimates of the resident population of the United States for July 1, 2011 - July 1, 2016, by year, county, single year of age (range: 0 to 85 years), bridged-race (white, black or African American, American Indian or Alaska Native, Asian, or Pacific Islander), Hispanic ethnicity (not Hispanic or Latino, Hispanic or Latino), and sex (Vintage 2016), prepared under a collaborative arrangement with the U.S. Census Bureau. Population estimates for states as of June 26, 2017 are available at https://www.cdc.gov/nchs/nvss/bridged_race/data_documentation.htm. Population estimates for territories are the 2016 mid-year estimates from the U.S. Census Bureau International Data Base accessed on July 24, 2017 at https://www.census.gov/population/international/data/idb/informationGateway.php. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  • Annual tables for 2016 and later years are available on CDC WONDER.
  • Annual summary reports from 1993-2015 are available as published in the MMWR.
  • NNDSS annual tables since 1952 are available at CDC Stacks (once in CDC Stacks select "Annual Reports" in the "Genre" box to the left).
Suggested Citation:
  • Centers for Disease Control and Prevention. National Notifiable Diseases Surveillance System, 2016 Annual Tables of Infectious Disease Data. Atlanta, GA. CDC Division of Health Informatics and Surveillance, 2017. Available at: https://www.cdc.gov/nndss/infectious-tables.html.
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