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National Notifiable Infectious Diseases and Conditions: United States

TABLE 1. Reported cases of notifiable diseases and rates per 100,000, excluding U.S. territories - - United States, 2016
Disease Case Count Rate
Anthrax
Arboviral diseases
Chikungunya virus disease 247 0.08
Eastern equine encephalitis virus disease
Neuroinvasive 7 0.00
Non-neuroinvasive
Jamestown Canyon virus disease
Neuroinvasive 7 0.00
Non-neuroinvasive 8 0.00
La Crosse virus disease
Neuroinvasive 31 0.01
Non-neuroinvasive 4 0.00
Powassan virus disease
Neuroinvasive 21 0.01
Non-neuroinvasive 1 0.00
St. Louis encephalitis virus disease
Neuroinvasive 7 0.00
Non-neuroinvasive 1 0.00
West Nile virus disease
Neuroinvasive 1,308 0.40
Non-neuroinvasive 841 0.26
Western equine encephalitis virus disease
Neuroinvasive
Non-neuroinvasive
Babesiosis
Total 1,910 0.83
Confirmed 1,585 0.69
Probable 325 0.14
Botulism
Total 201 0.06
Foodborne 31 0.01
Infant 144 3.63
Other (wound & unspecified) 26 0.01
Brucellosis 127 0.04
Campylobacteriosis 60,120 18.61
Chancroid 7 0.00
Chlamydia trachomatis infection 1,598,354 494.65
Cholera 15 0.00
Coccidioidomycosis * 11,829 9.01
Cryptosporidiosis
Total 13,453 4.16
Confirmed 8,637 2.67
Probable 4,816 1.49
Cyclosporiasis 537 0.18
Dengue virus infections †
Dengue 903 0.28
Dengue-like illness 40 0.01
Severe dengue 10 0.00
Diphtheria
Ehrlichiosis and Anaplasmosis
Anaplasma phagocytophilum infection 4,151 1.33
Ehrlichia chaffeensis infection 1,377 0.44
Ehrlichia ewingii infection 22 0.01
Undetermined ehrlichiosis/anaplasmosis 200 0.06
Giardiasis 16,310 6.43
Gonorrhea 468,514 144.99
Haemophilus influenzae, invasive disease
All ages, all serotypes 4,895 1.51
Age <5 years
Serotype b 30 0.15
Non-b serotype 159 0.80
Nontypeable 196 0.98
Unknown serotype 187 0.94
Hansen's disease 78 0.03
Hantavirus infection, non-hantavirus pulmonary syndrome 6 0.00
Hantavirus pulmonary syndrome 31 0.01
Hemolytic uremic syndrome post-diarrheal 307 0.10
Hepatitis §
A, acute 2,007 0.62
B, acute 3,218 1.00
B, perinatal infection 32 0.40
C, acute 2,942 0.97
Human immunodeficiency virus diagnoses 34,775 10.76
Influenza-associated pediatric mortality 82 0.11
Invasive pneumococcal disease
All ages 17,626 7.32
Confirmed 17,603 7.31
Probable 23 0.01
Age <5 years 1,142 0.44
Confirmed 1,137 7.13
Probable 5 0.03
Legionellosis 6,141 1.90
Leptospirosis 78 0.03
Listeriosis 786 0.24
Lyme disease
Total 36,429 11.32
Confirmed 26,203 8.15
Probable 10,226 3.18
Malaria 1,955 0.61
Measles
Total 85 0.03
Indigenous 68 0.02
Imported 17 0.01
Meningococcal disease
All serogroups 375 0.12
Serogroups ACWY 126 0.04
Serogroup B 86 0.03
Other serogroups 21 0.01
Unknown serogroup 142 0.04
Mumps 6,369 1.97
Novel Influenza A virus infections 23 0.01
Pertussis 17,972 5.56
Plague 4 0.00
Poliomyelitis, paralytic
Poliovirus infection, nonparalytic
Psittacosis 12 0.00
Q fever
Total 164 0.05
Acute 132 0.04
Chronic 32 0.01
Rabies
Animal 4,609 1.51
Human
Rubella 1 0.00
Rubella, congenital syndrome 2 0.05
Salmonellosis 53,850 16.67
Severe acute respiratory syndrome-associated coronavirus disease
Shiga toxin-producing Escherichia coli ¶ 8,169 2.53
Shigellosis 21,097 6.53
Smallpox
Spotted fever rickettsiosis
Total 4,269 1.33
Confirmed 154 0.05
Probable 4,115 1.28
Streptococcal toxic shock syndrome 283 0.14
Syphilis
Total, all stages ** 88,042 27.25
Congenital 628 15.82
Primary and secondary 27,814 8.61
Tetanus 34 0.01
Toxic shock syndrome (other than Streptococcal) 40 0.02
Trichinellosis 26 0.01
Tuberculosis 9,272 2.87
Tularemia 230 0.07
Typhoid fever 376 0.12
Vancomycin-intermediate Staphylococcus aureus 108 0.04
Vancomycin-resistant Staphylococcus aureus
Varicella morbidity 8,953 3.45
Varicella mortality 3 0.00
Vibriosis
Total 1,273 0.40
Confirmed 1,241 0.39
Probable 32 0.01
Viral hemorrhagic fevers
Crimean-Congo hemorrhagic fever virus
Ebola virus
Guanarito virus
Junin virus
Lassa virus
Lujo virus
Machupo virus
Marburg virus
Sabia virus
Yellow fever 1 0.00
Zika virus
Zika virus disease, congenital †† 30 0.76
Zika virus disease, non-congenital 5,132 1.59
Zika virus infection, congenital †† 45 1.13
Zika virus infection, non-congenital 911 0.28
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    —: No reported cases
  • * Reportable in <25 states.
  • † Total number of reported laboratory-positive dengue cases, including all confirmed cases [by anti-dengue virus (DENV) molecular diagnostic methods or seroconversion of anti-DENV IgM] and all probable cases (by a single, positive anti-DENV IgM).
  • § Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/2015surveillance/index.htm.
  • ¶ Includes Escherichia coli O157:H7; shiga toxin-positive, serogroup non-O157; and shiga toxin positive, not serogrouped.
  • ** Includes syphilis of all stages, including cases where stage of syphilis is not stated.
  • †† Data reported to ArboNET using the national surveillance case definition for congenital Zika virus disease or infection (CSTE Position Statement 16-ID-01). Additional data reported to the US Zika Pregnancy Registry for outcomes of pregnancies with laboratory evidence of possible Zika virus infection are available at https://www.cdc.gov/zika/reporting/pregnancy-outcomes.html. Cases reported to the US Zika Pregnancy Registry might not meet the national surveillance case definition for congenital Zika virus disease or infection.

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