Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 2h. Annual reported cases of notifiable diseases, by region and reporting area, United States and U.S. Territories, excluding Non-U.S. Residents*, 2019†
Data from some jurisdictions may be incomplete due to the coronavirus disease 2019 (COVID-19) pandemic. Please see Note #9 at the bottom of the table.
Reporting Area Hantavirus infection, non-hantavirus pulmonary syndrome § Hantavirus pulmonary syndrome Hemolytic uremic syndrome post-diarrheal Hepatitis 
A, acute B, acute B, perinatal infection C, acute C, perinatal infection
Confirmed Probable
U.S. Residents, excluding U.S. Territories 3 18 392 18,846 3,544 19 4,136 1,343 217
New England — 1 4 593 112 1 237 53 18
Connecticut N N 1 17 3 — 7 — —
Maine — — 1 45 58 1 43 16 4
Massachusetts — — 1 204 37 — 161 7 14
New Hampshire — 1 1 309 5 — 20 30 —
Rhode Island — — — 6 U U U U U
Vermont — — — 12 9 — 6 — —
Middle Atlantic — — 20 1,697 256 4 615 62 32
New Jersey — — — 610 78 — 99 4 11
New York (excluding New York City) — — 6 290 51 — 226 27 —
New York City — — 3 101 36 2 80 26 1
Pennsylvania — — 11 696 91 2 210 5 20
East North Central — 1 35 3,486 598 — 991 258 76
Illinois — 1 8 185 45 — 156 8 10
Indiana — — 5 1,398 170 — 325 62 14
Michigan — — 8 70 64 — 117 14 11
Ohio — — 5 1,802 311 — 281 170 41
Wisconsin — — 9 31 8 — 112 4 —
West North Central 1 2 54 481 90 — 164 5 9
Iowa — — 7 9 25 — 10 — —
Kansas N — 9 10 11 — 19 2 2
Minnesota — — 11 76 16 — 62 — 5
Missouri N — 15 359 33 — 41 — —
Nebraska — — 3 15 — — 4 — —
North Dakota — — 4 4 — — — — —
South Dakota 1 2 5 8 5 — 28 3 2
South Atlantic 1 1 36 5,967 1,294 5 1,018 346 39
Delaware — — — 36 12 — U U U
District of Columbia N — — 15 U U U U —
Florida — — 4 3,392 759 1 616 208 20
Georgia — — 10 844 114 — 61 22 5
Maryland 1 1 3 88 41 — 33 6 —
North Carolina — — 6 154 189 2 150 37 —
South Carolina — — — 662 46 — 9 20 2
Virginia N — 10 309 57 2 70 28 12
West Virginia — — 3 467 76 — 79 25 —
East South Central — — 39 3,848 650 5 417 442 16
Alabama N — 6 242 75 2 87 16 —
Kentucky — — 18 1,318 188 — 128 118 —
Mississippi — — — 128 49 2 U U —
Tennessee — — 15 2,160 338 1 202 308 16
West South Central — 1 39 1,062 212 — 147 56 3
Arkansas N — 8 203 39 — 58 16 3
Louisiana — — 2 687 73 — 8 — —
Oklahoma N 1 8 13 31 — 23 14 —
Texas — — 21 159 69 — 58 26 N
Mountain — 8 33 1,245 134 — 236 70 4
Arizona — — 7 584 49 — U U —
Colorado — 1 13 333 17 — 45 11 1
Idaho N 1 4 75 7 — 17 3 —
Montana — — — 15 1 — 17 2 —
Nevada — 2 — 102 23 — 15 12 1
New Mexico — 3 1 104 5 — 10 4 —
Utah — 1 8 20 29 — 127 38 2
Wyoming — — — 12 3 — 5 — —
Pacific 1 4 132 467 198 4 311 51 20
Alaska — — 1 2 6 — N N 2
California 1 3 124 256 111 4 200 10 15
Hawaii — — — 1 1 — 7 9 —
Oregon — — 7 27 28 — 23 13 —
Washington N 1 N 181 52 — 81 19 3
Territories — — — 278 5 — — — —
American Samoa — N N — — — — — —
Commonwealth of Northern Mariana Islands — — — — — — — — —
Guam — N — 226 — — — — —
Puerto Rico — — N 52 5 — N N —
U.S. Virgin Islands — — — — — — — — —
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
  • U: Unavailable — The data are unavailable.
  • * The 2019 annual tables exclude cases of nationally notifiable conditions and diseases among non-U.S. residents. As a result, data in Table 2 does not include a "Non-U.S. Resident" or "Total" row, that would have been included in the table had the data been stratified into the following four categories, based upon the "country of usual residence" (COUR) algorithm: U.S. Residents, excluding U.S. Territories; U.S. Territories; Non-US. Residents; and Total.Table 2 for the 2019 annual tables only includes the first two of these stratification categories.
  • † To calculate rates, use the populations provided in Table 8. Note that calculation of rates for the following conditions use population subsets presented in Table 8: Zika virus infection, congenital; Zika virus disease, congenital; Infant botulism; Congenital rubella syndrome; Perinatal Hepatitis B infection, Perinatal Hepatitis C infection, Haemophilus influenzae, invasive disease and Invasive pneumococcal disease, and Influenza associated pediatric mortality; see Table 8 (population reference table). Also see notes 3 and 7.
  • § Includes data for old world hantavirus infections, such as Seoul virus and Puumala virus infections.
  • ¶ Chronic hepatitis B and C data are not included in NNDSS tables but reported case counts are included in the annual Summary of Viral Hepatitis, published online by CDC's Division of Viral Hepatitis, available at https://www.cdc.gov/hepatitis/statistics/SurveillanceRpts.htm.
Notes:
  1. These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables.
  2. The list of national notifiable infectious diseases and conditions for 2019 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2019" for the notifiable condition list year, checking "infectious" conditions, and clicking "Get Notifiable List by Year". This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved in 2018 by CSTE for national surveillance that were implemented in January 2019. Candida auris, clinical became a new national notifiable condition, and revised case definitions were implemented for the following conditions: diphtheria, acute hepatitis A, listeriosis, yellow fever, Salmonella Paratyphi infection and Salmonella Typhi infection. Salmonella Paratyphi infection and Salmonella Typhi infection replaced Paratyphoid fever and Typhoid fever, respectively, as national notifiable conditions. Salmonellosis (excluding S. Typhi infection and S. Paratyphi infection) replaced Salmonellosis (excluding paratyphoid fever and typhoid fever) as a national notifiable condition. In addition, Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae (CP-CRE) represents a consolidation of CP-CRE species Klebsiella spp, CP-CRE E. coli, and CP-CRE Enterobacter spp. Publication criteria for the finalized 2019 data are available at https://wonder.cdc.gov/nndss/documents/2019_NNDSS _Publication_Criteria_01212021.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  3. Population estimates for incidence rates are July 1st, 2019, estimates obtained from the National Center for Health Statistics (NCHS) postcensal estimates of the resident population of the United States for April 1, 2010, to July 1, 2019, by year, county, single year of age (range: 0 to 85 years), bridged-race (white, black or African American, American Indian or Alaska Native, Asian, or Pacific Islander), Hispanic ethnicity (not Hispanic or Latino, Hispanic or Latino), and sex (Vintage 2019), prepared under a collaborative arrangement with the U.S. Census Bureau. Population estimates for states released July 9, 2020, are available at https://www.cdc.gov/nchs/nvss/bridged_race/data_documentation.htm. Population estimates for territories are the 2019 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on August 6, 2020, at https://www.census.gov/data-tools/demo/idb/#/country?YR_ANIM=2021. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  4. Annual tables for 2016 and later years are available on CDC WONDER.
  5. Annual summary reports from 1993–2015 are available as published in the Morbidity and Mortality Weekly Report.
  6. NNDSS annual tables since 1952 are available at CDC Stacks (once in CDC Stacks, select "Annual Reports" in the "Genre" box to the left).
  7. For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a national notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations.

    Age restrictions in the numerator and denominator are applied for the following childhood conditions:

    • Zika virus disease, congenital (age restriction in numerator and denominator is <1 year)
    • Zika virus infection, congenital (age restriction in numerator and denominator is <1 year)
    • Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years)
    • Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years)
    • Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years)
    • Infant botulism (age restriction in numerator and denominator is <1 year)
    • Congenital rubella syndrome (age restriction in numerator and denominator is <1 year)
    • Perinatal Hepatitis B infection (age restriction in numerator is ≤24 months, denominator is <24 months)
    • Perinatal Hepatitis C infection (age restriction in numerator is ≤36 months, denominator is <36 months).

    Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2019 (National Center for Health Statistics Natality 2019, as compiled from data provided by the Vital Statistics Cooperative Program). The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases. Congenital syphilis data are published in Syphilis Statistics in the sexually transmitted diseases (STD) surveillance report (https://www.cdc.gov/std/syphilis/stats.htm) and in the historical archives of the STD surveillance report (https://www.cdc.gov/std/stats/archive.htm). The STD surveillance report (https://www.cdc.gov/std/syphilis/stats.htm) updates congenital syphilis cases and rates over time.

  8. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC).
  9. The following 24 jurisdictions may have incomplete data, due to the coronavirus disease 2019 (COVID-19) pandemic: Alaska, California, Connecticut, Delaware, District of Columbia, Florida, Idaho, Indiana, Kansas, Massachusetts, Minnesota, Missouri, Montana, Nebraska, New Hampshire, New York (excluding New York City), New York City, North Dakota, Ohio, Oklahoma, South Carolina, Tennessee, Texas, and West Virginia. In addition, the following 2 U.S. Territories may have incomplete data due to the COVID-19 pandemic: American Samoa and the U.S. Virgin Islands.
Suggested Citation: Acknowledgment:
  • CDC acknowledges the local, state, and territorial health departments that collected the data from a range of case ascertainment sources (e.g., healthcare providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System.