Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 2i. Annual reported cases of notifiable diseases, by region and reporting area, United States and U.S. Territories, excluding Non-U.S. Residents*, 2019†
Data from some jurisdictions may be incomplete due to the coronavirus disease 2019 (COVID-19) pandemic. Please see Note #9 at the bottom of the table.
Reporting Area Human immunodeficiency virus diagnoses Influenza-associated pediatric mortality Invasive pneumococcal disease § Legionellosis Leptospirosis
All ages Age <5 years
Confirmed Probable Confirmed Probable
U.S. Residents, excluding U.S. Territories 31,723 160 19,689 262 1,091 24 8,890 94
New England 723 7 1,139 6 48 — 488 —
Connecticut 165 1 254 — 11 — 119 N
Maine 30 1 169 — 5 — 30 —
Massachusetts 437 4 446 4 23 — 247 —
New Hampshire 27 — 130 — 1 — 32 —
Rhode Island 54 — 84 1 7 — 48 —
Vermont 10 1 56 1 1 — 12 —
Middle Atlantic 3,893 14 2,963 61 137 2 1,949 9
New Jersey 860 6 621 35 27 — 318 —
New York (excluding New York City) 594 4 900 1 38 1 606 N
New York City 1,511 2 770 15 37 — 446 6
Pennsylvania 928 2 672 10 35 1 579 3
East North Central 3,241 20 3,390 66 185 9 2,445 12
Illinois 1,108 7 N N 36 1 614 3
Indiana 466 2 728 2 32 — 263 3
Michigan 652 3 979 21 47 1 551 3
Ohio 821 4 1,232 43 47 7 785 —
Wisconsin 194 4 451 — 23 — 232 3
West North Central 1,074 16 1,559 49 80 1 513 8
Iowa 92 1 N N N N 68 N
Kansas 119 2 — — — — 66 N
Minnesota 265 3 527 — 34 — 118 1
Missouri 470 5 667 44 17 1 183 4
Nebraska 78 4 192 1 15 — 46 3
North Dakota 31 — 76 — 9 — 9 N
South Dakota 19 1 97 4 5 — 23 —
South Atlantic 10,346 26 3,236 29 221 3 1,613 15
Delaware 88 — 70 1 4 — 35 —
District of Columbia 233 — 55 — 2 — 41 —
Florida 4,341 7 868 16 87 3 448 7
Georgia 1,969 4 942 — 54 — 171 1
Maryland 783 5 466 2 24 — 273 2
North Carolina 1,339 5 N N N N 305 3
South Carolina 665 — 489 9 18 — 67 —
Virginia 806 5 21 — 20 — 191 —
West Virginia 122 — 325 1 12 — 82 2
East South Central 1,912 8 1,936 6 92 — 389 1
Alabama 536 2 433 1 28 — 72 —
Kentucky 232 3 383 1 13 — 121 1
Mississippi 421 — 327 — 25 — 47 N
Tennessee 723 3 793 4 26 — 149 N
West South Central 4,423 27 2,745 37 207 7 589 1
Arkansas 265 1 385 — 33 — 66 N
Louisiana 901 2 429 1 21 — 50 1
Oklahoma 188 1 N N 18 — 52 —
Texas 3,069 23 1,931 36 135 7 421 N
Mountain 1,825 17 2,459 6 110 1 309 4
Arizona 646 2 738 2 33 — 93 —
Colorado 431 3 585 1 18 — 90 N
Idaho 21 — N N 8 — 25 N
Montana 25 — 130 1 5 — 14 1
Nevada 442 4 381 — 12 — 25 —
New Mexico 121 5 363 — 17 — 21 —
Utah 126 3 225 2 16 1 38 3
Wyoming 13 — 37 — 1 — 3 —
Pacific 4,286 25 262 2 11 1 595 44
Alaska 27 2 152 2 4 1 2 —
California 3,533 18 N N N N 451 8
Hawaii 57 — 110 — 7 — 11 30
Oregon 186 2 N N N N 55 2
Washington 483 3 N N N N 76 4
Territories 345 — 2 — — — 4 95
American Samoa — — N N N N N —
Commonwealth of Northern Mariana Islands 2 — — — — — — —
Guam 9 — — — — — 1 2
Puerto Rico 334 — 2 — — — 3 93
U.S. Virgin Islands — — — — — — — —
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
  • U: Unavailable — The data are unavailable.
  • * The 2019 annual tables exclude cases of nationally notifiable conditions and diseases among non-U.S. residents. As a result, data in Table 2 does not include a "Non-U.S. Resident" or "Total" row, that would have been included in the table had the data been stratified into the following four categories, based upon the "country of usual residence" (COUR) algorithm: U.S. Residents, excluding U.S. Territories; U.S. Territories; Non-US. Residents; and Total.Table 2 for the 2019 annual tables only includes the first two of these stratification categories.
  • † To calculate rates, use the populations provided in Table 8. Note that calculation of rates for the following conditions use population subsets presented in Table 8: Zika virus infection, congenital; Zika virus disease, congenital; Infant botulism; Congenital rubella syndrome; Perinatal Hepatitis B infection, Perinatal Hepatitis C infection, Haemophilus influenzae, invasive disease and Invasive pneumococcal disease, and Influenza associated pediatric mortality; see Table 8 (population reference table). Also see notes 3 and 7.
  • § Counts include drug resistant and susceptible cases of Invasive Pneumococcal Disease. This condition was previously named Streptococcus pneumoniae invasive disease and cases were reported to CDC using different event codes to specify whether the cases were drug resistant or in a defined age group, such as <5 years.
Notes:
  1. These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables.
  2. The list of national notifiable infectious diseases and conditions for 2019 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2019" for the notifiable condition list year, checking "infectious" conditions, and clicking "Get Notifiable List by Year". This list incorporates the Council of State and Territorial Epidemiologists (CSTE) position statements approved in 2018 by CSTE for national surveillance that were implemented in January 2019. Candida auris, clinical became a new national notifiable condition, and revised case definitions were implemented for the following conditions: diphtheria, acute hepatitis A, listeriosis, yellow fever, Salmonella Paratyphi infection and Salmonella Typhi infection. Salmonella Paratyphi infection and Salmonella Typhi infection replaced Paratyphoid fever and Typhoid fever, respectively, as national notifiable conditions. Salmonellosis (excluding S. Typhi infection and S. Paratyphi infection) replaced Salmonellosis (excluding paratyphoid fever and typhoid fever) as a national notifiable condition. In addition, Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae (CP-CRE) represents a consolidation of CP-CRE species Klebsiella spp, CP-CRE E. coli, and CP-CRE Enterobacter spp. Publication criteria for the finalized 2019 data are available at https://wonder.cdc.gov/nndss/documents/2019_NNDSS _Publication_Criteria_01212021.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  3. Population estimates for incidence rates are July 1st, 2019, estimates obtained from the National Center for Health Statistics (NCHS) postcensal estimates of the resident population of the United States for April 1, 2010, to July 1, 2019, by year, county, single year of age (range: 0 to 85 years), bridged-race (white, black or African American, American Indian or Alaska Native, Asian, or Pacific Islander), Hispanic ethnicity (not Hispanic or Latino, Hispanic or Latino), and sex (Vintage 2019), prepared under a collaborative arrangement with the U.S. Census Bureau. Population estimates for states released July 9, 2020, are available at https://www.cdc.gov/nchs/nvss/bridged_race/data_documentation.htm. Population estimates for territories are the 2019 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on August 6, 2020, at https://www.census.gov/data-tools/demo/idb/#/country?YR_ANIM=2021. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  4. Annual tables for 2016 and later years are available on CDC WONDER.
  5. Annual summary reports from 1993–2015 are available as published in the Morbidity and Mortality Weekly Report.
  6. NNDSS annual tables since 1952 are available at CDC Stacks (once in CDC Stacks, select "Annual Reports" in the "Genre" box to the left).
  7. For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a national notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations.

    Age restrictions in the numerator and denominator are applied for the following childhood conditions:

    • Zika virus disease, congenital (age restriction in numerator and denominator is <1 year)
    • Zika virus infection, congenital (age restriction in numerator and denominator is <1 year)
    • Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years)
    • Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years)
    • Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years)
    • Infant botulism (age restriction in numerator and denominator is <1 year)
    • Congenital rubella syndrome (age restriction in numerator and denominator is <1 year)
    • Perinatal Hepatitis B infection (age restriction in numerator is ≤24 months, denominator is <24 months)
    • Perinatal Hepatitis C infection (age restriction in numerator is ≤36 months, denominator is <36 months).

    Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2019 (National Center for Health Statistics Natality 2019, as compiled from data provided by the Vital Statistics Cooperative Program). The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases. Congenital syphilis data are published in Syphilis Statistics in the sexually transmitted diseases (STD) surveillance report (https://www.cdc.gov/std/syphilis/stats.htm) and in the historical archives of the STD surveillance report (https://www.cdc.gov/std/stats/archive.htm). The STD surveillance report (https://www.cdc.gov/std/syphilis/stats.htm) updates congenital syphilis cases and rates over time.

  8. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC).
  9. The following 24 jurisdictions may have incomplete data, due to the coronavirus disease 2019 (COVID-19) pandemic: Alaska, California, Connecticut, Delaware, District of Columbia, Florida, Idaho, Indiana, Kansas, Massachusetts, Minnesota, Missouri, Montana, Nebraska, New Hampshire, New York (excluding New York City), New York City, North Dakota, Ohio, Oklahoma, South Carolina, Tennessee, Texas, and West Virginia. In addition, the following 2 U.S. Territories may have incomplete data due to the COVID-19 pandemic: American Samoa and the U.S. Virgin Islands.
Suggested Citation: Acknowledgment:
  • CDC acknowledges the local, state, and territorial health departments that collected the data from a range of case ascertainment sources (e.g., healthcare providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System.