Nationally Notifiable Infectious Diseases and Conditions, United States: Annual Tables

TABLE 2e. Annual reported cases* of notifiable diseases, by region and reporting area, United States, U.S. Territories, and Non-U.S. Residents, 2022†
Reporting Area Cholera Coccidioidomycosis Coronavirus Disease 2019 (COVID-19) Cryptosporidiosis Cyclosporiasis
Total Confirmed Probable § Total Confirmed Probable
U.S. Residents, excluding U.S. Territories 12 17,612 43,132,795 34,277,404 8,855,391 12,606 10,169 2,437 3,091
New England 3 6 1,971,937 1,625,537 346,400 432 301 131 69
Connecticut 3 N 393,353 338,701 54,652 52 52 — 25
Maine — N 150,219 104,864 45,355 61 38 23 1
Massachusetts — N 982,600 872,631 109,969 172 122 50 38
New Hampshire — 5 165,603 107,007 58,596 45 13 32 2
Rhode Island — 1 197,948 128,161 69,787 62 55 7 2
Vermont — N 82,214 74,173 8,041 40 21 19 1
Middle Atlantic 2 — 5,400,707 4,677,782 722,925 2,053 1,779 274 346
New Jersey — N 1,194,605 956,628 237,977 595 502 93 69
New York (excluding New York City) — N 1,478,891 1,478,891 — 609 595 14 103
New York City 1 N 1,383,814 1,162,069 221,745 346 346 — 174
Pennsylvania 1 N 1,343,397 1,080,194 263,203 503 336 167 N
East North Central 3 99 5,391,750 4,247,069 1,144,681 2,167 1,658 509 372
Illinois 3 N 1,414,663 1,171,734 242,929 491 394 97 196
Indiana — 15 735,840 525,693 210,147 268 260 8 15
Michigan — 40 1,223,669 1,011,235 212,434 331 219 112 56
Ohio — 28 1,223,904 851,611 372,293 531 390 141 41
Wisconsin — 16 793,674 686,796 106,878 546 395 151 64
West North Central — 182 2,502,579 1,841,289 661,290 1,657 1,260 397 151
Iowa — N 355,998 246,498 109,500 476 392 84 36
Kansas — 8 373,236 260,427 112,809 111 106 5 24
Minnesota — 130 671,968 548,276 123,692 528 355 173 42
Missouri — 22 710,156 531,360 178,796 263 245 18 28
Nebraska — 12 193,868 123,802 70,066 130 103 27 19
North Dakota — 2 106,982 63,551 43,431 52 21 31 —
South Dakota — 8 90,371 67,375 22,996 97 38 59 2
South Atlantic — 2 8,798,389 6,618,798 2,179,591 2,260 1,786 474 1,016
Delaware — — 132,005 117,164 14,841 42 17 25 4
District of Columbia — N 77,568 73,819 3,749 3 3 — 2
Florida — N 3,027,000 2,248,225 778,775 618 441 177 508
Georgia — N 1,142,168 869,112 273,056 480 470 10 189
Maryland — 2 706,220 532,791 173,429 174 173 1 56
North Carolina — N 1,631,273 1,300,479 330,794 370 299 71 133
South Carolina — N 772,971 572,372 200,599 167 144 23 62
Virginia — N 1,056,039 715,795 340,244 271 143 128 57
West Virginia — N 253,145 189,041 64,104 135 96 39 5
East South Central 1 25 2,894,632 1,848,528 1,046,104 788 662 126 76
Alabama — 12 663,035 444,866 218,169 158 85 73 19
Kentucky — 13 797,288 513,709 283,579 291 245 46 25
Mississippi — N 392,022 191,813 200,209 90 90 — N
Tennessee 1 N 1,042,287 698,140 344,147 249 242 7 32
West South Central 1 13 5,127,678 3,663,615 1,464,063 1,043 876 167 720
Arkansas — 6 398,859 242,924 155,935 98 65 33 12
Louisiana 1 7 646,070 422,729 223,341 182 129 53 72
Oklahoma — N 525,215 339,767 185,448 97 92 5 N
Texas — N 3,557,534 2,658,195 899,339 666 590 76 636
Mountain — 9,821 3,193,547 2,790,999 402,548 870 657 213 131
Arizona — 9,515 988,649 821,336 167,313 127 111 16 12
Colorado — N 758,258 668,382 89,876 266 219 47 87
Idaho — N 188,299 135,061 53,238 70 57 13 N
Montana — 18 126,760 82,854 43,906 56 52 4 4
Nevada — 170 334,946 303,529 31,417 31 21 10 N
New Mexico — 71 302,844 302,448 396 82 80 2 7
Utah — 43 427,836 427,575 261 211 94 117 19
Wyoming — 4 65,955 49,814 16,141 27 23 4 2
Pacific 2 7,464 7,851,576 6,963,787 887,789 1,336 1,190 146 210
Alaska — N 134,335 122,058 12,277 8 5 3 2
California 1 7,459 5,973,659 5,342,193 631,466 943 877 66 156
Hawaii 1 N 242,937 200,657 42,280 22 22 — 1
Oregon — 5 513,101 480,563 32,538 118 58 60 8
Washington — N 987,544 818,316 169,228 245 228 17 43
U.S. Territories — — 889,868 308,770 581,098 1 — 1 —
American Samoa — N 8,302 8,302 — N N N N
Commonwealth of Northern Mariana Islands — — 11,216 9,705 1,511 — — — —
Guam — — 40,409 34,712 5,697 — — — —
Puerto Rico — N 816,266 242,376 573,890 1 — 1 —
U.S. Virgin Islands — — 13,675 13,675 — — — — —
Non-U.S. Residents — 1 — — — 1 1 — 1
Total 12 17,613 44,022,663 34,586,174 9,436,489 12,608 10,170 2,438 3,092
  • —: No reported cases — The reporting jurisdiction did not submit any cases to CDC.
  • N: Not reportable — The disease or condition was not reportable by law, statute, or regulation in the reporting jurisdiction.
  • U: Unavailable — The data are unavailable.
  • * Cases are assigned to the reporting jurisdiction submitting the case to NNDSS if the case's country of usual residence is the United States, a U.S. territory, unknown, or country is not reported; otherwise, the case is assigned to the Non-U.S. Residents' category. Country of usual residence is currently not reported by all jurisdictions or for all conditions because this data element is only available in the HL7 generic version 2 and disease-specific message mapping guides. If a jurisdiction sends data in legacy formats, they are not able to send this information. For further information on interpretation of these data, see https://www.cdc.gov/nndss/data-statistics/readers-guides/.
  • † To calculate rates, use the populations provided in Table 8. Note that calculation of rates for the following conditions uses population subgroups as described in note #7 and population counts presented in Table 8: Zika virus infection, congenital; Zika virus disease, congenital; Infant botulism; Congenital rubella syndrome; Perinatal Hepatitis B infection; Perinatal Hepatitis C infection; Haemophilus influenzae, invasive disease; Invasive pneumococcal disease; and Influenza-associated pediatric mortality. Also see Notes #3 and #7.
  • § Of the reporting areas that submitted 2022 aggregate COVID-19 data to CDC, three did not submit probable cases. American Samoa, New York (excluding New York City), and U.S. Virgin Islands did not collect probable cases.
Notes:
  1. These are annual cases of selected infectious national notifiable diseases from the National Notifiable Diseases Surveillance System (NNDSS). NNDSS data reported by the 50 states, New York City, the District of Columbia, and the U.S. territories are collated and published. Cases are reported by state health departments to CDC weekly. Because source datasets may be updated as additional information is received, statistics in publications based on that source data may differ from what is presented in these tables. Source datasets for the 2022 annual tables were officially closed on March 29, 2024.
  2. The list of national notifiable Infectious diseases and conditions for 2022 and their national surveillance case definitions are available by navigating to the Surveillance Case Definitions | CDC web page, selecting "2022" for the notifiable condition list year, checking "Infectious" conditions, and clicking "Get Notifiable List by Year". Publication criteria for the finalized 2022 data are available at https://wonder.cdc.gov/nndss/documents/NNDSS_Publication_Criteria_2022.pdf. See also Guide to Interpreting Provisional and Finalized NNDSS Data.
  3. Population estimates for incidence rates are July 1st, 2022 postcensal estimates of the resident population of the United States for July 1, 2020, to July 1, 2022, by year, county, single year of age (range: 0 to 85+ years), bridged-race (American Indian or Alaska Native, Asian or Pacific Islander, Black or African American, White), Hispanic ethnicity (Hispanic or Latino, not Hispanic or Latino), and sex (Female, Male), prepared under a collaborative arrangement with the U.S. Census Bureau and the National Cancer Institute (NCI). The "Vintage 2022" population estimates for years 2020-2022 were released March 2024 by the National Cancer Institute at https://seer.cancer.gov/popdata/. For more information, see https://seer.cancer.gov/popdata/singleages.html Population estimates for territories are the 2022 mid-year estimates from the U.S. Census Bureau International Data Base, accessed on May 02, 2024, at https://www.census.gov/data-tools/demo/idb/#/country?YR_ANIM=2022. The choice of population denominators for incidence is based on the availability of population data at the time of publication preparation.
  4. Annual tables for 2016 and later years are available on CDC WONDER.
  5. Annual summary reports from 1993–2015 are available as published in the Morbidity and Mortality Weekly Report.
  6. NNDSS annual tables since 1952 are available at CDC Stacks. To find them, search for "NNDSS" under Collections. Once in NNDSS Collections, navigate to the "Genre" box on the left-hand side and select "Annual Reports".
  7. For most conditions, national incidence rates are calculated as the number of reported cases for each infectious disease or condition divided by the U.S. resident population for the specified demographic population or the total U.S. resident population, multiplied by 100,000. When a national notifiable infectious condition is associated with a specific age restriction, the same restriction was applied to the population in the denominator of the incidence rate calculation. In addition, population data from reporting jurisdictions in which the disease or condition was not reportable or not available were excluded from the denominator of the incidence rate calculations.

    Age restrictions in the numerator and denominator are applied for the following childhood conditions:

    • Zika virus disease, congenital (age restriction in numerator and denominator is <1 year)
    • Zika virus infection, congenital (age restriction in numerator and denominator is <1 year)
    • Haemophilus influenzae, invasive disease <5 years (age restriction in numerator and denominator is <5 years)
    • Invasive pneumococcal disease <5 years (age restriction in numerator and denominator is <5 years)
    • Influenza associated pediatric mortality (age restriction in numerator and denominator is <18 years)
    • Infant botulism (age restriction in numerator and denominator is <1 year)
    • Congenital rubella syndrome (age restriction in numerator and denominator is <1 year)
    • Perinatal hepatitis B infection (age restriction is ≤24 months)
    • Perinatal hepatitis C infection (age restriction is ≤36 months).

    Data for congenital syphilis are aggregated by the infant's year of birth. The rate for congenital syphilis is based upon the number of reported cases per 100,000 live births, using natality data for 2022 (National Center for Health Statistics Natality 2022, as compiled from data provided by the Vital Statistics Cooperative Program). Congenital syphilis cases are usually assigned to the mother's state of residence at the time of delivery. The mother's race and ethnicity are used for race- and ethnicity-specific rates of congenital syphilis cases.

  8. Surveillance data reported by other CDC programs might vary from data reported in these tables because of differences in 1) the date used to aggregate the data, 2) the timing of reports, 3) the source of the data, 4) surveillance case definitions, and 5) policies regarding case jurisdiction (i.e., which jurisdiction should submit the case notification to CDC).
  9. Disease data presented in the 2022 tables reflect impacts of the COVID-19 pandemic, such as changes in exposure-related behavior, healthcare-seeking behavior, disease reporting, and public health investigations.
Suggested Citation: Acknowledgment:
  • CDC acknowledges the local, state, and territorial health departments that collected the data from a range of case ascertainment sources (e.g., healthcare providers, hospitals, laboratories) and reported these data to CDC's National Notifiable Diseases Surveillance System.